Follow
Denise Wootten
Title
Cited by
Cited by
Year
Mechanisms of signalling and biased agonism in G protein-coupled receptors
D Wootten, A Christopoulos, M Marti-Solano, MM Babu, PM Sexton
Nature reviews Molecular cell biology 19 (10), 638-653, 2018
5682018
Emerging paradigms in GPCR allostery: implications for drug discovery
D Wootten, A Christopoulos, PM Sexton
Nature reviews Drug discovery 12 (8), 630-644, 2013
5032013
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ...
Nature 546 (7656), 118-123, 2017
4782017
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment
I Kufareva, M Rueda, V Katritch, RC Stevens, R Abagyan
Structure 19 (8), 1108-1126, 2011
3442011
Lifting the lid on GPCRs: the role of extracellular loops
M Wheatley, D Wootten, MT Conner, J Simms, R Kendrick, RT Logan, ...
British journal of pharmacology 165 (6), 1688-1703, 2012
3352012
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
CJ Draper-Joyce, M Khoshouei, DM Thal, YL Liang, ATN Nguyen, ...
Nature 558 (7711), 559-563, 2018
3192018
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau, PM Sexton, LJ Miller, JM Ahn, ...
Pharmacological reviews 68 (4), 954-1013, 2016
2992016
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ...
Nature 555 (7694), 121-125, 2018
2962018
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
YL Liang, M Khoshouei, G Deganutti, A Glukhova, C Koole, TS Peat, ...
Nature 561 (7724), 492-497, 2018
2282018
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family BG protein-coupled receptor conformations
D Wootten, J Simms, LJ Miller, A Christopoulos, PM Sexton
Proceedings of the National Academy of Sciences 110 (13), 5211-5216, 2013
2282013
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner …
C Koole, D Wootten, J Simms, C Valant, R Sridhar, OL Woodman, ...
Molecular pharmacology 78 (3), 456-465, 2010
2252010
The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism
D Wootten, CA Reynolds, KJ Smith, JC Mobarec, C Koole, EE Savage, ...
Cell 165 (7), 1632-1643, 2016
1382016
Activation of the GLP-1 receptor by a non-peptidic agonist
P Zhao, YL Liang, MJ Belousoff, G Deganutti, MM Fletcher, FS Willard, ...
Nature 577 (7790), 432-436, 2020
1272020
Structural basis of Gs and Gi recognition by the human glucagon receptor
A Qiao, S Han, X Li, Z Li, P Zhao, A Dai, R Chang, L Tai, Q Tan, X Chu, ...
Science 367 (6484), 1346-1352, 2020
1262020
Ligand-dependent modulation of G protein conformation alters drug efficacy
SGB Furness, YL Liang, CJ Nowell, ML Halls, PJ Wookey, E Dal Maso, ...
Cell 167 (3), 739-749. e11, 2016
1252016
Differential GLP-1R binding and activation by peptide and non-peptide agonists
X Zhang, MJ Belousoff, P Zhao, AJ Kooistra, TT Truong, SY Ang, ...
Molecular Cell 80 (3), 485-500. e7, 2020
1162020
Rules of engagement: GPCRs and G proteins
A Glukhova, CJ Draper-Joyce, RK Sunahara, A Christopoulos, D Wootten, ...
ACS pharmacology & translational science 1 (2), 73-83, 2018
1082018
Allostery and biased agonism at class BG protein-coupled receptors
D Wootten, LJ Miller, C Koole, A Christopoulos, PM Sexton
Chemical reviews 117 (1), 111-138, 2017
1032017
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation
C Koole, D Wootten, J Simms, LJ Miller, A Christopoulos, PM Sexton
Journal of Biological Chemistry 287 (6), 3642-3658, 2012
1012012
Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands
D Wootten, EE Savage, FS Willard, AB Bueno, KW Sloop, A Christopoulos, ...
Molecular pharmacology 83 (4), 822-834, 2013
1002013
The system can't perform the operation now. Try again later.
Articles 1–20