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| Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy C Tovar, J Rosinski, Z Filipovic, B Higgins, K Kolinsky, H Hilton, X Zhao, ... Proceedings of the National Academy of Sciences 103 (6), 1888-1893, 2006 | 809 | 2006 |
| Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1 LT Vassilev, C Tovar, S Chen, D Knezevic, X Zhao, H Sun, DC Heimbrook, ... Proceedings of the National Academy of Sciences 103 (28), 10660-10665, 2006 | 793 | 2006 |
| Stapled α− helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy YS Chang, B Graves, V Guerlavais, C Tovar, K Packman, KH To, ... Proceedings of the National Academy of Sciences 110 (36), E3445-E3454, 2013 | 724 | 2013 |
| MDM2 inhibitors for cancer therapy LT Vassilev Trends in molecular medicine 13 (1), 23-31, 2007 | 634 | 2007 |
| Discovery of RG7388, a potent and selective p53–MDM2 inhibitor in clinical development Q Ding, Z Zhang, JJ Liu, N Jiang, J Zhang, TM Ross, XJ Chu, D Bartkovitz, ... Journal of medicinal chemistry 56 (14), 5979-5983, 2013 | 605 | 2013 |
| Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism … I Ray-Coquard, JY Blay, A Italiano, A Le Cesne, N Penel, J Zhi, F Heil, ... The lancet oncology 13 (11), 1133-1140, 2012 | 591 | 2012 |
| Subtype and pathway specific responses to anticancer compounds in breast cancer LM Heiser, A Sadanandam, WL Kuo, SC Benz, TC Goldstein, S Ng, ... Proceedings of the National Academy of Sciences 109 (8), 2724-2729, 2012 | 539 | 2012 |
| MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy K Kojima, M Konopleva, IJ Samudio, M Shikami, M Cabreira-Hansen, ... Blood 106 (9), 3150-3159, 2005 | 450 | 2005 |
| Discovery of RG7112: a small-molecule MDM2 inhibitor in clinical development B Vu, P Wovkulich, G Pizzolato, A Lovey, Q Ding, N Jiang, JJ Liu, C Zhao, ... ACS medicinal chemistry letters 4 (5), 466-469, 2013 | 407 | 2013 |
| Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics LT Vassilev Cell cycle 3 (4), 417-419, 2004 | 351 | 2004 |
| Identification of an origin of bidirectional DNA replication in mammalian chromosomes WC Burhans, LT Vassilev, MS Caddle, NH Heintz, ML DePamphills Cell 62 (5), 955-965, 1990 | 328 | 1990 |
| MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models C Tovar, B Graves, K Packman, Z Filipovic, BHM Xia, C Tardell, R Garrido, ... Cancer research 73 (8), 2587-2597, 2013 | 313 | 2013 |
| Phosphorylation of p53 on Key Serines Is Dispensable for Transcriptional Activation and Apoptosis*♦ T Thompson, C Tovar, H Yang, D Carvajal, BT Vu, Q Xu, GM Wahl, ... Journal of Biological Chemistry 279 (51), 53015-53022, 2004 | 286 | 2004 |
| Targeting the p53–MDM2 interaction to treat cancer C Klein, LT Vassilev British journal of cancer 91 (8), 1415-1419, 2004 | 261 | 2004 |
| MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells L Coll-Mulet, D Iglesias-Serret, AF Santidrián, AM Cosialls, M de Frias, ... Blood 107 (10), 4109-4114, 2006 | 257 | 2006 |
| Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors D Carvajal, C Tovar, H Yang, BT Vu, DC Heimbrook, LT Vassilev Cancer research 65 (5), 1918-1924, 2005 | 252 | 2005 |
| Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization B Graves, T Thompson, M Xia, C Janson, C Lukacs, D Deo, P Di Lello, ... Proceedings of the National Academy of Sciences 109 (29), 11788-11793, 2012 | 250 | 2012 |
| p53 Activation by small molecules: application in oncology LT Vassilev Journal of medicinal chemistry 48 (14), 4491-4499, 2005 | 222 | 2005 |
| Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation H Yang, Z Filipovic, D Brown, SN Breit, LT Vassilev Molecular Cancer Therapeutics 2 (10), 1023-1029, 2003 | 211 | 2003 |
