Deepak Perumal
Deepak Perumal
Principal Scientist,Legend Biotech
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YAP 1 Regulates OCT 4 Activity and SOX 2 Expression to Facilitate Self‐Renewal and Vascular Mimicry of Stem‐Like Cells
N Bora‐Singhal, J Nguyen, C Schaal, D Perumal, S Singh, D Coppola, ...
Stem cells 33 (6), 1705-1718, 2015
Gli1-mediated regulation of Sox2 facilitates self-renewal of stem-like cells and confers resistance to EGFR inhibitors in non–small cell lung cancer
N Bora-Singhal, D Perumal, J Nguyen, S Chellappan
Neoplasia 17 (7), 538-551, 2015
Stage-specific human induced pluripotent stem cells map the progression of myeloid transformation to transplantable leukemia
AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, ...
Cell stem cell 20 (3), 315-328. e7, 2017
Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification
D Perumal, CS Lim, KR Sakharkar, MK Sakharkar
In silico biology 7 (4, 5), 453-465, 2007
High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma
PY Kuo, VV Leshchenko, MJ Fazzari, D Perumal, T Gellen, T He, J Iqbal, ...
Oncogene 34 (10), 1231-1240, 2015
A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC
D Perumal, S Singh, SJ Yoder, GC Bloom, SP Chellappan
PLoS One 7 (8), e43589, 2012
Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma
A Laganą, D Perumal, D Melnekoff, B Readhead, BA Kidd, V Leshchenko, ...
Leukemia, 1-11, 2017
Nicotinic acetylcholine receptors induce c-Kit ligand/stem cell factor and promote stemness in an ARRB1/β-arrestin-1 dependent manner in NSCLC
D Perumal, S Pillai, J Nguyen, C Schaal, D Coppola, SP Chellappan
Oncotarget 5 (21), 10486, 2014
Targeting multiple targets in Pseudomonas aeruginosa PAO1 using flux balance analysis of a reconstructed genome-scale metabolic network
D Perumal, A Samal, KR Sakharkar, MK Sakharkar
Journal of drug targeting 19 (1), 1-13, 2011
Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner
S Nair, N Bora-Singhal, D Perumal, S Chellappan
Molecular cancer 13 (1), 1-16, 2014
A phase 2 study of panobinostat with lenalidomide and weekly dexamethasone in myeloma
A Chari, HJ Cho, A Dhadwal, G Morgan, L La, K Zarychta, D Catamero, ...
Blood advances 1 (19), 1575-1583, 2017
SOX11 augments BCR signaling to drive MCL-like tumor development
PY Kuo, SS Jatiani, AH Rahman, D Edwards, Z Jiang, K Ahr, D Perumal, ...
Blood, The Journal of the American Society of Hematology 131 (20), 2247-2255, 2018
Dual targeting of CDK4 and ARK5 using a novel kinase inhibitor ON123300 exerts potent anticancer activity against multiple myeloma
D Perumal, PY Kuo, VV Leshchenko, Z Jiang, SKA Divakar, HJ Cho, ...
Cancer research 76 (5), 1225-1236, 2016
Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas
SKA Divakar, MVR Reddy, SC Cosenza, SJ Baker, D Perumal, ...
Leukemia 30 (1), 86-93, 2016
A combined computational-experimental analyses of selected metabolic enzymes in Pseudomonas species
D Perumal, CS Lim, VTK Chow, KR Sakharkar, MK Sakharkar
International journal of biological sciences 4 (5), 309, 2008
Precision medicine for relapsed multiple myeloma on the basis of an integrative multiomics approach
A Laganą, I Beno, D Melnekoff, V Leshchenko, D Madduri, D Ramdas, ...
JCO precision oncology 2, 1-17, 2018
A comparative study of metabolic network topology between a pathogenic and a non-pathogenic bacterium for potential drug target identification
D Perumal, CS Lim, MK Sakharkar
Summit on translational bioinformatics 2009, 100, 2009
Weighted Gene Co-Expression Network Analysis (WGCNA) Identifies Highly Proliferative Myeloma Subgroup Responsive to CDK4/ARK5 Inhibition
D Perumal, VV Leshchenko, PY Kuo, Z Jiang, B Readhead, C Eden, ...
Blood, The Journal of the American Society of Hematology 124 (21), 3445-3445, 2014
Cloning and targeted disruption of two lipopolysaccharide biosynthesis genes, kdsA and waaG, of Pseudomonas aeruginosa PAO1 by site-directed mutagenesis
D Perumal, KR Sakharkar, TH Tang, VTK Chow, CS Lim, A Samal, ...
Journal of molecular microbiology and biotechnology 19 (4), 169-179, 2010
In silico Identification of Putative Drug Targets in Pseudomonas aeruginosa Through Metabolic Pathway Analysis
D Perumal, CS Lim, MK Sakharkar
IAPR International Workshop on Pattern Recognition in Bioinformatics, 323-336, 2007
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