Keng-Chang Tsai (蔡耿彰)
Keng-Chang Tsai (蔡耿彰)
National Research Institute of Chinese Medicine,Taiwan
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Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity
JJ Shie, JM Fang, SY Wang, KC Tsai, YSE Cheng, AS Yang, SC Hsiao, ...
Journal of the American Chemical Society 129 (39), 11892-11893, 2007
Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling
WC Chen, TS Tseng, NW Hsiao, YL Lin, ZH Wen, CC Tsai, YC Lee, ...
Scientific reports 5, 7995, 2015
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease
IL Lu, N Mahindroo, PH Liang, YH Peng, CJ Kuo, KC Tsai, HP Hsieh, ...
Journal of medicinal chemistry 49 (17), 5154-5161, 2006
Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto: a novel nucleophilic catalytic mechanism for nattokinase
Z Zheng, Z Zuo, Z Liu, K Tsai, A Liu, G Zou
Journal of Molecular Graphics and Modelling 23 (4), 373-380, 2005
A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity
JJ Shie, JM Fang, PT Lai, WH Wen, SY Wang, YSE Cheng, KC Tsai, ...
Journal of the American Chemical Society 133 (44), 17959-17965, 2011
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies
KC Tsai, SY Chen, PH Liang, IL Lu, N Mahindroo, HP Hsieh, YS Chao, ...
Journal of medicinal chemistry 49 (12), 3485-3495, 2006
Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses
WH Wen, SY Wang, KC Tsai, YSE Cheng, AS Yang, JM Fang, CH Wong
Bioorganic & medicinal chemistry 18 (11), 4074-4084, 2010
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease
YM Shao, WB Yang, TH Kuo, KC Tsai, CH Lin, AS Yang, PH Liang, ...
Bioorganic & medicinal chemistry 16 (8), 4652-4660, 2008
Dual-wing folder radio telephone
T Kim
US Patent 7,181,253, 2007
A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies
KC Tsai, YC Chen, NW Hsiao, CL Wang, CL Lin, YC Lee, M Li, B Wang
European journal of medicinal chemistry 45 (4), 1544-1551, 2010
Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae ACTIVATION OF MACROPHAGES THROUGH TOLL…
FL Yang, YL Yang, PC Liao, JC Chou, KC Tsai, AS Yang, F Sheu, TL Lin, ...
Journal of Biological Chemistry 286 (24), 21041-21051, 2011
The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents
LP Du, KC Tsai, MY Li, QD You, L Xia
Bioorganic & medicinal chemistry letters 14 (18), 4771-4777, 2004
How to generate reliable and predictive CoMFA models
L Zhang, KC Tsai, L Du, H Fang, M Li, W Xu
Current medicinal chemistry 18 (6), 923-930, 2011
Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.
SY Wang, CP Tseng, KC Tsai, CF Lin, CY Wen, HS Tsay, N Sakamoto, ...
Biochemical and Biophysical Research Communications 385 (2), 230-235, 2009
Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface
CM Yu, HP Peng, C Chen, YC Lee, JB Chen, KC Tsai, CT Chen, ...
PloS one 7 (3), e33340, 2012
Implementing the Fisher's Discriminant Ratio in ak-Means Clustering Algorithm for Feature Selection and Data Set Trimming
TH Lin, HT Li, KC Tsai
Journal of chemical information and computer sciences 44 (1), 76-87, 2004
The effect of different electrostatic potentials on docking accuracy: a case study using DOCK5. 4
KC Tsai, SH Wang, NW Hsiao, M Li, B Wang
Bioorganic & medicinal chemistry letters 18 (12), 3509-3512, 2008
Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-β-Hexosaminidase Inhibitors
CW Ho, SD Popat, TW Liu, KC Tsai, MJ Ho, WH Chen, AS Yang, CH Lin
ACS chemical biology 5 (5), 489-497, 2010
Pharmacophore identification of α1A-adrenoceptor antagonists
MY Li, KC Tsai, L Xia
Bioorganic & medicinal chemistry letters 15 (3), 657-664, 2005
Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling
SN Lo, YP Chang, KC Tsai, CY Chang, TS Wu, YF Ueng
Toxicology and applied pharmacology 272 (3), 671-680, 2013
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