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Loss of ZnT8 function protects against diabetes by enhanced insulin secretion OP Dwivedi, M Lehtovirta, B Hastoy, V Chandra, NAJ Krentz, S Kleiner, ... Nature genetics 51 (11), 1596-1606, 2019 | 129 | 2019 |
Systematic functional characterization of candidate causal genes for type 2 diabetes risk variants SK Thomsen, A Ceroni, M van de Bunt, C Burrows, A Barrett, ... Diabetes 65 (12), 3805-3811, 2016 | 98 | 2016 |
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells SK Thomsen, A Raimondo, B Hastoy, S Sengupta, XQ Dai, A Bautista, ... Nature genetics 50 (8), 1122-1131, 2018 | 88 | 2018 |
Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability A Raimondo, AJ Chakera, SK Thomsen, K Colclough, A Barrett, ... Human molecular genetics 23 (24), 6432-6440, 2014 | 61 | 2014 |
Loss-of-function mutations in the cell-cycle control gene CDKN2A impact on glucose homeostasis in humans A Pal, TP Potjer, SK Thomsen, HJ Ng, A Barrett, R Scharfmann, TJ James, ... Diabetes 65 (2), 527-533, 2016 | 56 | 2016 |
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Prioritising causal genes at type 2 diabetes risk loci AK Grotz, AL Gloyn, SK Thomsen Current diabetes reports 17, 1-9, 2017 | 42 | 2017 |
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk AK Rottner, Y Ye, E Navarro-Guerrero, V Rajesh, A Pollner, RJ Bevacqua, ... Nature Genetics 55 (1), 54-65, 2023 | 31 | 2023 |
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci KJ Gaulton, T Ferreira, Y Lee, A Raimondo, R Mägi, ME Reschen, ... Nat Genet 47 (12), 1415-1425, 2015 | 30 | 2015 |
Human genetics as a model for target validation: finding new therapies for diabetes SK Thomsen, AL Gloyn Diabetologia 60 (6), 960-970, 2017 | 25 | 2017 |
Tissue-specific alteration of metabolic pathways influences glycemic regulation NHJ Ng, SM Willems, J Fernandez, RS Fine, E Wheeler, J Wessel, ... BioRxiv, 790618, 2019 | 11 | 2019 |
A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk AK Grotz, E Navarro-Guerrero, RJ Bevacqua, R Baronio, SK Thomsen, ... bioRxiv, 2021.05. 28.445984, 2021 | 9 | 2021 |
Type 2 diabetes risk alleles reveal a role for peptidylglycine alpha-amidating monooxygenase in beta cell function A Raimondo, SK Thomsen, B Hastoy, MM Umapathysivam, XQ Dai, ... bioRxiv, 158642, 2017 | 5 | 2017 |
Keys to the kingdom SCK Wong, LS Sasportas, K Richardson, BR Gordon, MKP Jayatunga, ... Nature Biotechnology 33 (3), 232-236, 2015 | 5 | 2015 |
The importance of context: uncovering species-and tissue-specific effects of genetic risk variants for type 2 diabetes SK Thomsen, MI McCarthy, AL Gloyn Frontiers in Endocrinology 7, 112, 2016 | 4 | 2016 |
Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists MM Umapathysivam, E Araldi, B Hastoy, AY Dawed, H Vatandaslar, ... medRxiv, 2023 | 3 | 2023 |
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Device for sampling gastro-intestinal material S Rees, L Ashton, C Iveson, A Chomka, S Thomsen, NHJ Ng, P Albers, ... US Patent 11,937,791, 2024 | 2 | 2024 |
Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists E Araldi, MM Umapathysivam, B Hastoy, AY Dawed, H Vatandaslar, ... FEBS OPEN BIO 14, 467-467, 2024 | | 2024 |