|The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy|
JN Sleigh, TH Gillingwater, K Talbot
Disease models & mechanisms 4 (4), 457-467, 2011
|Conserved genes act as modifiers of invertebrate SMN loss of function defects|
M Dimitriadi, JN Sleigh, A Walker, HC Chang, A Sen, G Kalloo, J Harris, ...
PLoS Genet 6 (10), e1001172, 2010
|Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy|
SM Hammond, G Hazell, F Shabanpoor, AF Saleh, M Bowerman, ...
Proceedings of the National Academy of Sciences 113 (39), 10962-10967, 2016
|Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy|
JN Sleigh, A Barreiro-Iglesias, PL Oliver, A Biba, T Becker, KE Davies, ...
Human molecular genetics 23 (4), 855-869, 2014
|A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform …|
JN Sleigh, SD Buckingham, B Esmaeili, M Viswanathan, E Cuppen, ...
Human molecular genetics 20 (2), 245-260, 2011
|A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia|
JN Sleigh, GA Weir, G Schiavo
BMC research notes 9 (1), 1-7, 2016
|Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot–Marie–Tooth type 2D mice|
JN Sleigh, SJ Grice, RW Burgess, K Talbot, MZ Cader
Human molecular genetics 23 (10), 2639-2650, 2014
|Vascular defects and spinal cord hypoxia in spinal muscular atrophy|
E Somers, RD Lees, K Hoban, JN Sleigh, H Zhou, F Muntoni, K Talbot, ...
Annals of neurology 79 (2), 217-230, 2016
|Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles|
JN Sleigh, RW Burgess, TH Gillingwater, MZ Cader
Journal of neuroscience methods 227, 159-165, 2014
|Synaptic deficits at neuromuscular junctions in two mouse models of Charcot–Marie–Tooth type 2d|
EL Spaulding, JN Sleigh, KH Morelli, MJ Pinter, RW Burgess, KL Seburn
Journal of Neuroscience 36 (11), 3254-3267, 2016
|Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice|
BJ Turner, N Alfazema, RK Sheean, JN Sleigh, KE Davies, MK Horne, ...
Neurobiology of aging 35 (4), 906-915, 2014
|Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations|
JN Sleigh, JM Dawes, SJ West, N Wei, EL Spaulding, A Gómez-Martín, ...
Proceedings of the National Academy of Sciences 114 (16), E3324-E3333, 2017
|Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology|
SJ Grice, JN Sleigh, WW Motley, JL Liu, RW Burgess, K Talbot, MZ Cader
Human molecular genetics 24 (15), 4397-4406, 2015
|Loss of Lrsam1, a Charcot-Marie-Tooth disease-associated E3 ubiquitin ligase, sensitizes peripheral axons to degeneration in mice|
LP Bogdanik, JN Sleigh, C Tian, ME Samuels, K Bedard, KL Seburn, ...
Disease Models & Mechanisms, dmm. 010942, 2013
|In vivo imaging of axonal transport in murine motor and sensory neurons|
KL Gibbs, B Kalmar, JN Sleigh, L Greensmith, G Schiavo
Journal of Neuroscience Methods 257, 26-33, 2016
|Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics|
SJ Grice, JN Sleigh, JL Liu, DB Sattelle
Bioessays 33 (12), 956-965, 2011
|Axonal transport and neurological disease|
JN Sleigh, AM Rossor, AD Fellows, AP Tosolini, G Schiavo
Nature Reviews Neurology, 1-13, 2019
|Motor neuron gene therapy: lessons from spinal muscular atrophy for amyotrophic lateral sclerosis|
AP Tosolini, JN Sleigh
Frontiers in molecular neuroscience 10, 405, 2017
|Methodological advances in imaging intravital axonal transport|
JN Sleigh, A Vagnoni, AE Twelvetrees, G Schiavo
F1000Research 6, 2017
|Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition|
AL Kalinski, AN Kar, J Craver, AP Tosolini, JN Sleigh, SJ Lee, ...
Journal of Cell Biology 218 (6), 1871-1890, 2019