| Using ancient protein kinases to unravel a modern cancer drug’s mechanism C Wilson, RV Agafonov, M Hoemberger, S Kutter, A Zorba, J Halpin, ... Science 347 (6224), 882-886, 2015 | 183 | 2015 |
| Subpolar addition of new cell wall is directed by DivIVA in mycobacteria X Meniche, R Otten, MS Siegrist, CE Baer, KC Murphy, CR Bertozzi, ... Proceedings of the National Academy of Sciences 111 (31), E3243-E3251, 2014 | 179 | 2014 |
| The energy landscape of adenylate kinase during catalysis SJ Kerns, RV Agafonov, YJ Cho, F Pontiggia, R Otten, DV Pachov, ... Nature Structural and Molecular Biology 22 (2), 124, 2015 | 167 | 2015 |
| Fluoride resistance and transport by riboswitch-controlled CLC antiporters RB Stockbridge, HH Lim, R Otten, C Williams, T Shane, Z Weinberg, ... Proceedings of the National Academy of Sciences 109 (38), 15289-15294, 2012 | 159 | 2012 |
| Long unfolded linkers facilitate membrane protein import through the nuclear pore complex AC Meinema, JK Laba, RA Hapsari, R Otten, FAA Mulder, A Kralt, ... Science 333 (6038), 90-93, 2011 | 157 | 2011 |
| Energetic dissection of Gleevec's selectivity toward human tyrosine kinases RV Agafonov, C Wilson, R Otten, V Buosi, D Kern Nature Structural and Molecular Biology 21 (10), 848, 2014 | 127 | 2014 |
| How directed evolution reshapes the energy landscape in an enzyme to boost catalysis R Otten, RAP Pádua, HA Bunzel, V Nguyen, W Pitsawong, MK Patterson, ... Science 370 (6523), 1442-1446, 2020 | 125 | 2020 |
| Rescue of conformational dynamics in enzyme catalysis by directed evolution R Otten, L Liu, LR Kenner, MW Clarkson, D Mavor, DS Tawfik, D Kern, ... Nature Communications 9 (1), 1314, 2018 | 107 | 2018 |
| Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2 RAP Pádua, Y Sun, I Marko, W Pitsawong, JB Stiller, R Otten, D Kern Nature communications 9 (1), 4507, 2018 | 100 | 2018 |
| Comprehensive and cost-effective NMR spectroscopy of methyl groups in large proteins R Otten, B Chu, KD Krewulak, HJ Vogel, FAA Mulder Journal of the American Chemical Society 132 (9), 2952-2960, 2010 | 96 | 2010 |
| Comprehensive analysis of NMR data using advanced line shape fitting M Niklasson, R Otten, A Ahlner, C Andresen, J Schlagnitweit, K Petzold, ... Journal of biomolecular NMR 69 (2), 93-99, 2017 | 70 | 2017 |
| Conformational selection in a protein-protein interaction revealed by dynamic pathway analysis KS Chakrabarti, RV Agafonov, F Pontiggia, R Otten, MK Higgins, ... Cell reports 14 (1), 32-42, 2016 | 64 | 2016 |
| Probing Microsecond Time Scale Dynamics in Proteins by Methyl 1H Carr−Purcell−Meiboom−Gill Relaxation Dispersion NMR Measurements. Application to Activation of the Signaling … R Otten, J Villali, D Kern, FAA Mulder Journal of the American Chemical Society 132 (47), 17004-17014, 2010 | 58 | 2010 |
| Structure determination of high-energy states in a dynamic protein ensemble JB Stiller, R Otten, D Häussinger, PS Rieder, DL Theobald, D Kern Nature 603 (7901), 528-535, 2022 | 57 | 2022 |
| Cavity as a source of conformational fluctuation and high-energy state: High-pressure NMR study of a cavity-enlarged mutant of T4Lysozyme A Maeno, D Sindhikara, F Hirata, R Otten, FW Dahlquist, S Yokoyama, ... Biophysical journal 108 (1), 133-145, 2015 | 39 | 2015 |
| Dynamics of human protein kinase Aurora A linked to drug selectivity W Pitsawong, V Buosi, R Otten, RV Agafonov, A Zorba, N Kern, S Kutter, ... eLife 7, e36656, 2018 | 38 | 2018 |
| Protein surface and core dynamics show concerted hydration‐dependent activation K Wood, FX Gallat, R Otten, AJ Van Heel, M Lethier, L Van Eijck, M Moulin, ... Angewandte Chemie International Edition 52 (2), 665-668, 2013 | 38 | 2013 |
| The solution structure, binding properties, and dynamics of the bacterial siderophore-binding protein FepB BCH Chu, R Otten, KD Krewulak, FAA Mulder, HJ Vogel Journal of Biological Chemistry 289 (42), 29219-29234, 2014 | 37 | 2014 |
| Cystathionine β-synthase (CBS) domains 1 and 2 fulfill different roles in ionic strength sensing of the ATP-binding cassette (ABC) transporter OpuA A Karasawa, GB Erkens, RPA Berntsson, R Otten, GK Schuurman-Wolters, ... Journal of Biological Chemistry 286 (43), 37280-37291, 2011 | 32 | 2011 |
| Probing the transition state in enzyme catalysis by high-pressure NMR dynamics JB Stiller, SJ Kerns, M Hoemberger, YJ Cho, R Otten, MF Hagan, D Kern Nature Catalysis 2, 726–734, 2019 | 31 | 2019 |
