|11β-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response|
JW Tomlinson, EA Walker, IJ Bujalska, N Draper, GG Lavery, MS Cooper, ...
Endocrine reviews 25 (5), 831-866, 2004
|Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency|
N Draper, EA Walker, IJ Bujalska, JW Tomlinson, SM Chalder, W Arlt, ...
Nature genetics 34 (4), 434-439, 2003
|Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass …|
N Krone, BA Hughes, GG Lavery, PM Stewart, W Arlt, CHL Shackleton
The Journal of steroid biochemistry and molecular biology 121 (3-5), 496-504, 2010
|Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation|
GG Lavery, EA Walker, N Draper, P Jeyasuria, J Marcos, CHL Shackleton, ...
Journal of Biological Chemistry 281 (10), 6546-6551, 2006
|Targeted disruption of β-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex|
AC Kim, AL Reuter, M Zubair, T Else, K Serecky, NC Bingham, GG Lavery, ...
Development 135 (15), 2593-2602, 2008
|11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess|
SA Morgan, EL McCabe, LL Gathercole, ZK Hassan-Smith, DP Larner, ...
Proceedings of the National Academy of Sciences 111 (24), E2482-E2491, 2014
|11β-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle|
SA Morgan, M Sherlock, LL Gathercole, GG Lavery, C Lenaghan, ...
Diabetes 58 (11), 2506-2515, 2009
|CA-Repeat polymorphism in intron 1 of HSD11B2: effects on gene expression and salt sensitivity|
AK Agarwal, G Giacchetti, G Lavery, H Nikkila, M Palermo, M Ricketts, ...
Hypertension 36 (2), 187-194, 2000
|11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects|
LL Gathercole, GG Lavery, SA Morgan, MS Cooper, AJ Sinclair, ...
Endocrine reviews 34 (4), 525-555, 2013
|Premature adrenarche: novel lessons from early onset androgen excess|
J Idkowiak, GG Lavery, V Dhir, TG Barrett, PM Stewart, N Krone, W Arlt
European Journal of Endocrinology 165 (2), 189, 2011
|Prereceptor regulation of glucocorticoid action by 11β‐hydroxysteroid dehydrogenase: a novel determinant of cell proliferation|
EH Rabbitt, GG Lavery, EA Walker, MS Cooper, PM Stewart, M Hewison
The FASEB journal 16 (1), 36-44, 2002
|Association studies between microsatellite markers within the gene encoding human 11β-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and …|
N Draper, SM Echwald, GG Lavery, EA Walker, R Fraser, E Davies, ...
The Journal of Clinical Endocrinology & Metabolism 87 (11), 4984-4990, 2002
|11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects|
A Tiganescu, AA Tahrani, SA Morgan, M Otranto, A Desmoulière, ...
The Journal of clinical investigation 123 (7), 3051-3060, 2013
|Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy|
N Diguet, SAJ Trammell, C Tannous, R Deloux, J Piquereau, N Mougenot, ...
Circulation 137 (21), 2256-2273, 2018
|Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency|
GG Lavery, EA Walker, A Tiganescu, JP Ride, CHL Shackleton, ...
The Journal of Clinical Endocrinology & Metabolism 93 (10), 3827-3832, 2008
|Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy|
GG Lavery, EA Walker, N Turan, D Rogoff, JW Ryder, JM Shelton, ...
Journal of Biological Chemistry 283 (13), 8453-8461, 2008
|11β-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitary …|
EA Walker, A Ahmed, GG Lavery, JW Tomlinson, SY Kim, MS Cooper, ...
Journal of Biological Chemistry 282 (37), 27030-27036, 2007
|Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice|
JK Dowman, LJ Hopkins, GM Reynolds, MJ Armstrong, M Nasiri, ...
Endocrinology 154 (12), 4536-4547, 2013
|Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1|
GG Lavery, AE Zielinska, LL Gathercole, B Hughes, N Semjonous, ...
Endocrinology 153 (7), 3236-3248, 2012
|Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene|
GG Lavery, V Ronconi, N Draper, EH Rabbitt, V Lyons, KE Chapman, ...
Hypertension 42 (2), 123-129, 2003