Giovanni Lentini
Giovanni Lentini
Professore di Chimica Farmaceutica
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The chemistry and pharmacology of citrus limonoids
R Gualdani, MM Cavalluzzi, G Lentini, S Habtemariam
Molecules 21 (11), 1530, 2016
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective
MM Cavalluzzi, GF Mangiatordi, O Nicolotti, G Lentini
Expert opinion on drug discovery 12 (11), 1087-1104, 2017
Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels
A De Luca, F Natuzzi, JF Desaphy, G Loni, G Lentini, C Franchini, ...
Molecular Pharmacology 57 (2), 268-277, 2000
A mini-review on thalidomide: chemistry, mechanisms of action, therapeutic potential and anti-angiogenic properties in multiple myeloma
A Mercurio, G Adriani, A Catalano, A Carocci, L Rao, G Lentini, ...
Current medicinal chemistry 24 (25), 2736-2744, 2017
Phytochemical, Antioxidant and Anti‐α‐glucosidase Activity Evaluations of Bergenia cordifolia
M Roselli, G Lentini, S Habtemariam
Phytotherapy Research 26 (6), 908-914, 2012
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels
C Franchini, A Carocci, A Catalano, MM Cavalluzzi, F Corbo, G Lentini, ...
Journal of medicinal chemistry 46 (24), 5238-5248, 2003
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction
A Carocci, A Catalano, F Corbo, A Duranti, R Amoroso, C Franchini, ...
Tetrahedron: Asymmetry 11 (17), 3619-3634, 2000
The therapeutic potential of rutin for diabetes: an update
S Habtemariam, G Lentini
Mini Reviews in Medicinal Chemistry 15 (7), 524-528, 2015
Plant-derived anticancer agents: lessons from the pharmacology of geniposide and its aglycone, genipin
S Habtemariam, G Lentini
Biomedicines 6 (2), 39, 2018
New N-(phenoxydecyl) phthalimide derivatives displaying potent inhibition activity towards α-glucosidase
R Pascale, A Carocci, A Catalano, G Lentini, A Spagnoletta, ...
Bioorganic & medicinal chemistry 18 (16), 5903-5914, 2010
Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers
A De Luca, F Natuzzi, G Lentini, C Franchini, V Tortorella, ...
Naunyn-Schmiedeberg's archives of pharmacology 352 (6), 653-661, 1995
Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse
A De Luca, S Pierno, F Natuzzi, C Franchini, A Duranti, G Lentini, ...
Journal of Pharmacology and Experimental Therapeutics 282 (1), 93-100, 1997
Old drug scaffold, new activity: thalidomide‐correlated compounds exert different effects on breast cancer cell growth and progression
D Iacopetta, A Carocci, MS Sinicropi, A Catalano, G Lentini, J Ceramella, ...
ChemMedChem 12 (5), 381-389, 2017
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide
A De Luca, F Natuzzi, G Falcone, A Duranti, G Lentini, C Franchini, ...
Naunyn-Schmiedeberg's archives of pharmacology 356 (6), 777-787, 1997
COVID-19, chloroquine repurposing, and cardiac safety concern: chirality might help
G Lentini, MM Cavalluzzi, S Habtemariam
Molecules 25 (8), 1834, 2020
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors
A Carocci, A Catalano, A Lovece, G Lentini, A Duranti, V Lucini, ...
Bioorganic & medicinal chemistry 18 (17), 6496-6511, 2010
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents
MM Cavalluzzi, C Bruno, G Lentini, A Lovece, A Catalano, A Carocci, ...
Tetrahedron: Asymmetry 20 (17), 1984-1991, 2009
Synthesis of (R)-,(S)-, and (RS)-hydroxymethylmexiletine, one of the major metabolites of mexiletine
MM Cavalluzzi, A Catalano, C Bruno, A Lovece, A Carocci, F Corbo, ...
Tetrahedron: Asymmetry 18 (20), 2409-2417, 2007
Targeting the pregnane X receptor using microbial metabolite mimicry
Z Dvořák, F Kopp, CM Costello, JS Kemp, H Li, A Vrzalová, M Štěpánková, ...
EMBO molecular medicine 12 (4), e11621, 2020
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents
M De Bellis, A De Luca, F Rana, MM Cavalluzzi, A Catalano, G Lentini, ...
British journal of pharmacology 149 (3), 300-310, 2006
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