The chemistry and pharmacology of citrus limonoids R Gualdani, MM Cavalluzzi, G Lentini, S Habtemariam Molecules 21 (11), 1530, 2016 | 99 | 2016 |
Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels A De Luca, F Natuzzi, JF Desaphy, G Loni, G Lentini, C Franchini, ... Molecular Pharmacology 57 (2), 268-277, 2000 | 62 | 2000 |
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective MM Cavalluzzi, GF Mangiatordi, O Nicolotti, G Lentini Expert opinion on drug discovery 12 (11), 1087-1104, 2017 | 61 | 2017 |
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels C Franchini, A Carocci, A Catalano, MM Cavalluzzi, F Corbo, G Lentini, ... Journal of medicinal chemistry 46 (24), 5238-5248, 2003 | 60 | 2003 |
Phytochemical, Antioxidant and Anti‐α‐glucosidase Activity Evaluations of Bergenia cordifolia M Roselli, G Lentini, S Habtemariam Phytotherapy Research 26 (6), 908-914, 2012 | 59 | 2012 |
A mini-review on thalidomide: chemistry, mechanisms of action, therapeutic potential and anti-angiogenic properties in multiple myeloma A Mercurio, G Adriani, A Catalano, A Carocci, L Rao, G Lentini, ... Current medicinal chemistry 24 (25), 2736-2744, 2017 | 57 | 2017 |
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction A Carocci, A Catalano, F Corbo, A Duranti, R Amoroso, C Franchini, ... Tetrahedron: Asymmetry 11 (17), 3619-3634, 2000 | 54 | 2000 |
The therapeutic potential of rutin for diabetes: an update S Habtemariam, G Lentini Mini Reviews in Medicinal Chemistry 15 (7), 524-528, 2015 | 52 | 2015 |
Plant-derived anticancer agents: lessons from the pharmacology of geniposide and its aglycone, genipin S Habtemariam, G Lentini Biomedicines 6 (2), 39, 2018 | 48 | 2018 |
New N-(phenoxydecyl) phthalimide derivatives displaying potent inhibition activity towards α-glucosidase R Pascale, A Carocci, A Catalano, G Lentini, A Spagnoletta, ... Bioorganic & medicinal chemistry 18 (16), 5903-5914, 2010 | 46 | 2010 |
Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse A De Luca, S Pierno, F Natuzzi, C Franchini, A Duranti, G Lentini, ... Journal of Pharmacology and Experimental Therapeutics 282 (1), 93-100, 1997 | 46 | 1997 |
Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers A De Luca, F Natuzzi, G Lentini, C Franchini, V Tortorella, ... Naunyn-Schmiedeberg's archives of pharmacology 352 (6), 653-661, 1995 | 46 | 1995 |
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide A De Luca, F Natuzzi, G Falcone, A Duranti, G Lentini, C Franchini, ... Naunyn-Schmiedeberg's archives of pharmacology 356 (6), 777-787, 1997 | 42 | 1997 |
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors A Carocci, A Catalano, A Lovece, G Lentini, A Duranti, V Lucini, ... Bioorganic & medicinal chemistry 18 (17), 6496-6511, 2010 | 41 | 2010 |
Old drug scaffold, new activity: thalidomide‐correlated compounds exert different effects on breast cancer cell growth and progression D Iacopetta, A Carocci, MS Sinicropi, A Catalano, G Lentini, J Ceramella, ... ChemMedChem 12 (5), 381-389, 2017 | 39 | 2017 |
COVID-19, chloroquine repurposing, and cardiac safety concern: chirality might help G Lentini, MM Cavalluzzi, S Habtemariam Molecules 25 (8), 1834, 2020 | 37 | 2020 |
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents MM Cavalluzzi, C Bruno, G Lentini, A Lovece, A Catalano, A Carocci, ... Tetrahedron: Asymmetry 20 (17), 1984-1991, 2009 | 37 | 2009 |
Synthesis of (R)-,(S)-, and (RS)-hydroxymethylmexiletine, one of the major metabolites of mexiletine MM Cavalluzzi, A Catalano, C Bruno, A Lovece, A Carocci, F Corbo, ... Tetrahedron: Asymmetry 18 (20), 2409-2417, 2007 | 36 | 2007 |
Facile entry to (−)‐(R)‐ and (+)‐(S)‐mexiletine A Carocci, C Franchini, G Lentini, F Loiodice, V Tortorella Chirality: The Pharmacological, Biological, and Chemical Consequences of …, 2000 | 34 | 2000 |
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents M De Bellis, A De Luca, F Rana, MM Cavalluzzi, A Catalano, G Lentini, ... British journal of pharmacology 149 (3), 300-310, 2006 | 33 | 2006 |