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Nick Endres
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Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
N Jura, NF Endres, K Engel, S Deindl, R Das, MH Lamers, DE Wemmer, ...
Cell 137 (7), 1293-1307, 2009
6672009
Architecture and membrane interactions of the EGF receptor
A Arkhipov, Y Shan, R Das, NF Endres, MP Eastwood, DE Wemmer, ...
Cell 152 (3), 557-569, 2013
5272013
Conformational coupling across the plasma membrane in activation of the EGF receptor
NF Endres, R Das, AW Smith, A Arkhipov, E Kovacs, Y Huang, JG Pelton, ...
Cell 152 (3), 543-556, 2013
5202013
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms
N Jura, X Zhang, NF Endres, MA Seeliger, T Schindler, J Kuriyan
Molecular cell 42 (1), 9-22, 2011
3352011
A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd
NF Endres, C Yoshioka, RA Milligan, RD Vale
Nature 439 (7078), 875-878, 2006
1392006
Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3
M Imanishi, NF Endres, A Gennerich, RD Vale
The Journal of cell biology 174 (7), 931-937, 2006
1222006
Regulation of the catalytic activity of the EGF receptor
NF Endres, K Engel, R Das, E Kovacs, J Kuriyan
Current opinion in structural biology 21 (6), 777-784, 2011
1192011
Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases
NF Endres, T Barros, AJ Cantor, J Kuriyan
Trends in biochemical sciences 39 (10), 437-446, 2014
912014
Anisotropic Dynamics of the JE-2147−HIV Protease Complex:  Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09 Å Structure,
KK Reiling, NF Endres, DS Dauber, CS Craik, RM Stroud
Biochemistry 41 (14), 4582-4594, 2002
662002
RTK-dependent inducible degradation of mutant PI3Kα drives GDC-0077 (Inavolisib) efficacy
KW Song, KA Edgar, EJ Hanan, M Hafner, J Oeh, M Merchant, D Sampath, ...
Cancer discovery 12 (1), 204-219, 2022
422022
Discovery of GDC-0077 (inavolisib), a highly selective inhibitor and degrader of mutant PI3Kα
EJ Hanan, MG Braun, RA Heald, C MacLeod, C Chan, S Clausen, ...
Journal of Medicinal Chemistry 65 (24), 16589-16621, 2022
232022
Dynamic organization of myristoylated src in the live cell plasma membrane
AW Smith, HH Huang, NF Endres, C Rhodes, JT Groves
The Journal of Physical Chemistry B 120 (5), 867-876, 2016
182016
High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM
KS Li, JG Quinn, MJ Saabye, JFS Guerrero, J Nonomiya, Q Lian, ...
Analytical Chemistry 94 (2), 1230-1239, 2022
112022
Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors
C Nilewski, S Labadie, B Wei, S Malhotra, S Do, L Gazzard, L Liu, C Shao, ...
ACS Medicinal Chemistry Letters 15 (1), 21-28, 2023
12023
Constitutive protein degradation induces acute cell death via proteolysis products
SH Chen, S Prakash, E Helgason, CL Gilchrist, LR Kenner, R Srinivasan, ...
bioRxiv, 2023.02. 06.527237, 2023
12023
High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASᴳ¹²C by Intact Protein MS and Targeted MRM
KS Li, JG Quinn, MJ Saabye, JFS Guerrero, J Nonomiya, Q Lian, ...
2022
Selective degradation of mutant PIK3CA promotes increased mutant specificity in a subset of PI3K ATP-competitive inhibitors
L Nguyen, K Edgar, K Song, S Schmidt, V Schutz, N Ishisoko, E Torres, ...
MOLECULAR CANCER RESEARCH 18 (10), 43-43, 2020
2020
Abstract PR03: Selective degradation of mutant PIK3CA promotes increased mutant specificity in a subset of PI3K ATP-competitive inhibitors
L Nguyen, K Edgar, K Song, S Schmidt, V Schutz, N Ishisoko, E Torres, ...
Molecular Cancer Research 18 (10_Supplement), PR03-PR03, 2020
2020
Abstract# 3816: Insights into the activation mechanism of EGF receptor from the structure of the inactive kinase domain dimer
N Jura, N Endres, K Engel, S Deindl, X Zhang, J Kuriyan
Cancer Research 69 (9_Supplement), 3816-3816, 2009
2009
Examining kinesin motor family diversity: A mechanistic study of Ncd and OSM-3 motor proteins
NF Endres
University of California, San Francisco, 2006
2006
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Articles 1–20