Protein design algorithms predict viable resistance to an experimental antifolate SM Reeve, P Gainza, KM Frey, I Georgiev, BR Donald, AC Anderson Proceedings of the National Academy of Sciences 112 (3), 749-754, 2015 | 51 | 2015 |
Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus S Keshipeddy, SM Reeve, AC Anderson, DL Wright Journal of the American Chemical Society 137 (28), 8983-8990, 2015 | 39 | 2015 |
Charged nonclassical antifolates with activity against gram-positive and gram-negative pathogens E Scocchera, SM Reeve, S Keshipeddy, MN Lombardo, B Hajian, ... ACS medicinal chemistry letters 7 (7), 692-696, 2016 | 34 | 2016 |
Charged propargyl-linked antifolates reveal mechanisms of antifolate resistance and inhibit trimethoprim-resistant MRSA strains possessing clinically relevant mutations SM Reeve, E Scocchera, JJ Ferreira, N G-Dayanandan, S Keshipeddy, ... Journal of medicinal chemistry 59 (13), 6493-6500, 2016 | 29 | 2016 |
MRSA isolates from united states hospitals carry dfrg and dfrk resistance genes and succumb to propargyl-linked antifolates SM Reeve, EW Scocchera, G Narendran, S Keshipeddy, J Krucinska, ... Cell chemical biology 23 (12), 1458-1467, 2016 | 24 | 2016 |
Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis B Hajian, E Scocchera, S Keshipeddy, N G-Dayanandan, C Shoen, ... PloS one 11 (8), e0161740, 2016 | 21 | 2016 |
Novel cassette assay to quantify the outer membrane permeability of five β-lactams simultaneously in carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae TH Kim, X Tao, B Moya, Y Jiao, KB Basso, J Zhou, Y Lang, DS Sutaria, ... MBio 11 (1), 10.1128/mbio. 03189-19, 2020 | 18 | 2020 |
OSPREY predicts resistance mutations using positive and negative computational protein design A Ojewole, A Lowegard, P Gainza, SM Reeve, I Georgiev, AC Anderson, ... Computational Protein Design, 291-306, 2017 | 17 | 2017 |
Discovery and characterization of the antimetabolite action of thioacetamide-linked 1, 2, 3-triazoles as disruptors of cysteine biosynthesis in gram-negative bacteria MJ Wallace, S Dharuman, DM Fernando, SM Reeve, CT Gee, J Yao, ... ACS infectious diseases 6 (3), 467-478, 2019 | 16 | 2019 |
Toward broad spectrum dihydrofolate reductase inhibitors targeting trimethoprim resistant enzymes identified in clinical isolates of methicillin resistant Staphylococcus aureus SM Reeve, D Si, J Krucinska, Y Yan, K Viswanathan, S Wang, GT Holt, ... ACS Infectious Diseases 5 (11), 1896-1906, 2019 | 14 | 2019 |
A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance D Leshchiner, F Rosconi, B Sundaresh, E Rudmann, LMN Ramirez, ... Nature Communications 13 (1), 3165, 2022 | 12 | 2022 |
Combating multidrug‐resistant bacteria by integrating a novel target site penetration and receptor binding assay platform into translational modeling Y Lang, NR Shah, X Tao, SM Reeve, J Zhou, B Moya, ARM Sayed, ... Clinical Pharmacology & Therapeutics 109 (4), 1000-1020, 2021 | 12 | 2021 |
Azaindole based potentiator of antibiotics against gram-negative bacteria S Sharma, R Rao, SM Reeve, GA Phelps, N Bharatham, ... ACS Infectious Diseases 7 (11), 3009-3024, 2021 | 10 | 2021 |
Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery SM Reeve, MN Lombardo, AC Anderson Future microbiology 10 (11), 1727-1733, 2015 | 10 | 2015 |
Novel cassette assay to quantify the outer membrane permeability of five beta-lactams simultaneously in carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae … TH Kim, X Tao, B Moya, Y Jiao, KB Basso, J Zhou, Y Lang, DS Sutaria, ... | 8 | 2020 |
Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus S Wang, SM Reeve, GT Holt, AA Ojewole, MS Frenkel, P Gainza, ... PLoS computational biology 18 (2), e1009855, 2022 | 7 | 2022 |
Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins S Dharuman, LA Wilt, J Liu, SM Reeve, CW Thompson, JM Elmore, ... The Journal of antibiotics 74 (6), 381-396, 2021 | 6 | 2021 |
Structure-guided in vitro to in vivo pharmacokinetic optimization of propargyl-linked antifolates MN Lombardo, N G-Dayanandan, S Keshipeddy, W Zhou, D Si, ... Drug Metabolism and Disposition 47 (9), 995-1003, 2019 | 6 | 2019 |
G-Dayanadan SM Reeve, EW Scocchera N., Keshipeddy, S., Krucinska, J., Hajian, B., Ferreira, J., Nailor, M …, 2016 | 6 | 2016 |
G-Dayanandan, N.; Keshipeddy, S.; Wright, DL; Anderson, AC Charged propargyl-linked antifolates reveal mechanisms of antifolate resistance and inhibit trimethoprim-resistant … SM Reeve, E Scocchera, JJ Ferreira J. Med. Chem 59 (13), 6493-6500, 2016 | 6 | 2016 |