| A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. J Yrjänheikki, T Tikka, R Keinänen, G Goldsteins, PH Chan, J Koistinaho Proc Natl Acad Sci U S A 96 (23), 13496-500, 1999 | 1258 | 1999 |
| Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia T Tikka, BL Fiebich, G Goldsteins, R Keinänen, J Koistinaho Journal of Neuroscience 21 (8), 2580-2588, 2001 | 1114 | 2001 |
| Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. T Tikka, BL Fiebich, G Goldsteins, R Keinanen, J Koistinaho Journal of Neuroscience 21 (8), 2580-8, 2001 | 1114 | 2001 |
| Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia TM Tikka, JE Koistinaho J Immunology 166 (12), 7527-33, 2001 | 706 | 2001 |
| NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation AM Brennan, S Won Suh, S Joon Won, P Narasimhan, TM Kauppinen, ... Nature neuroscience 12 (7), 857-863, 2009 | 611 | 2009 |
| Astrocyte influences on ischemic neuronal death RA Swanson, W Ying, TM Kauppinen Current molecular medicine 4 (2), 193-205, 2004 | 603 | 2004 |
| NAD+ depletion is necessary and sufficient forPoly (ADP-Ribose) polymerase-1-mediated neuronal death CC Alano, P Garnier, W Ying, Y Higashi, TM Kauppinen, RA Swanson Journal of Neuroscience 30 (8), 2967-2978, 2010 | 506 | 2010 |
| Microglial activation in stroke: therapeutic targets MA Yenari, TM Kauppinen, RA Swanson Neurotherapeutics 7 (4), 378-391, 2010 | 436 | 2010 |
| Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke M Kawabori, R Kacimi, T Kauppinen, C Calosing, JY Kim, CL Hsieh, ... Journal of Neuroscience 35 (8), 3384-3396, 2015 | 327 | 2015 |
| Minocycline inhibits poly (ADP-ribose) polymerase-1 at nanomolar concentrations CC Alano, TM Kauppinen, AV Valls, RA Swanson Proceedings of the National Academy of Sciences 103 (25), 9685-9690, 2006 | 290 | 2006 |
| CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease SH Cho, B Sun, Y Zhou, TM Kauppinen, B Halabisky, P Wes, ... Journal of Biological Chemistry 286 (37), 32713-32722, 2011 | 278 | 2011 |
| Direct phosphorylation and regulation of poly (ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2 TM Kauppinen, WY Chan, SW Suh, AK Wiggins, EJ Huang, RA Swanson Proceedings of the National Academy of Sciences 103 (18), 7136-7141, 2006 | 264 | 2006 |
| Zinc triggers microglial activation TM Kauppinen, Y Higashi, SW Suh, C Escartin, K Nagasawa, ... Journal of Neuroscience 28 (22), 5827-5835, 2008 | 200 | 2008 |
| Poly (ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death TM Kauppinen, RA Swanson The Journal of Immunology 174 (4), 2288-2296, 2005 | 197 | 2005 |
| The role of poly (ADP-ribose) polymerase-1 in CNS disease TM Kauppinen, RA Swanson Neuroscience 145 (4), 1267-1272, 2007 | 189 | 2007 |
| Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease TM Tikka, NE Vartiainen, G Goldsteins, SS Oja, PM Andersen, ... Brain 125, 722-31, 2002 | 173 | 2002 |
| N‐acetylcysteine prevents loss of dopaminergic neurons in the EAAC1−/− mouse AE Berman, WY Chan, AM Brennan, RC Reyes, BL Adler, SW Suh, ... Annals of neurology 69 (3), 509-520, 2011 | 164 | 2011 |
| Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor JC d’Avila, TI Lam, D Bingham, J Shi, SJ Won, TM Kauppinen, S Massa, ... Journal of neuroinflammation 9, 1-11, 2012 | 154 | 2012 |
| Use of a poly (ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion AM Hamby, SW Suh, TM Kauppinen, RA Swanson Stroke 38 (2), 632-636, 2007 | 136 | 2007 |
| Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation T Tikka, T Usenius, M Tenhunen, R Keinänen, J Koistinaho Journal of Neurochemistry 78 (6), 1409-14, 2001 | 125 | 2001 |
