Prof. Assaf Friedler

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Zvi HayoukaThe Robert H. Smith Faculty of Agriculture, Food and Environment,The Hebrew University of JerusalemEmail verificata su mail.huji.ac.il
Alan FershtEmeritus Group Leader, MRC Laboratory of Molecular Biology, University of CambridgeEmail verificata su cam.ac.uk
Chaim GilonProfessor Emeritus Active, Institute of Chemistry, HUJIEmail verificata su mail.huji.ac.il
Dmitry VeprintsevProfessor of Molecular and Cellular Pharmacology, University of NottinghamEmail verificata su nottingham.ac.uk
Deborah E ShalevHebrew University of JerusalemEmail verificata su mail.huji.ac.il
Mattan HurevichAssociate Professor, Institute of Chemistry The Hebrew UniversityEmail verificata su mail.huji.ac.il
Joseph RosenbluhDepartment of Biochemistry & Molecular Biology, Monash UniversityEmail verificata su monash.edu
Oded LivnahEmail verificata su mail.huji.ac.il
Rachel NechushtaiThe Hebrew University of JerusalemEmail verificata su mail.huji.ac.il
Shahar SukenikDept. of Chemistry, Syracuse UniversityEmail verificata su syr.edu
Eric J SundbergEmory University School of MedicineEmail verificata su emory.edu
Daniel HarriesInstitute of Chemistry, The Hebrew UniversityEmail verificata su mail.huji.ac.il
KOUSHIK CHANDRAAssociate Professor in ChemistryEmail verificata su midnaporecollege.ac.in
Hermona SoreqProfessor of Molecular Neurobiology, The Hebrew University of JerusalemEmail verificata su mail.huji.ac.il
Penka NikolovaEmeritus Associate Professor (Reader), King's College LondonEmail verificata su kcl.ac.uk
Daniel BonsorFrederick National Laboratory for Cancer ResearchEmail verificata su nih.gov
Patricia A. JenningsProfessor of Chemistry and Biochemistry, UCSDEmail verificata su ucsd.edu
Masha NivThe Hebrew UniversityEmail verificata su mail.huji.ac.il
Tiago RitoThe Francis Crick InstituteEmail verificata su crick.ac.uk
Shoshana RavidProfessor of BiochemistryEmail verificata su mail.huji.ac.il

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Prof. Assaf Friedler

Institute of Chemistry, The Hebrew University of Jerusalem

Email verificata su mail.huji.ac.il - Home page

peptides protein interactions medicinal chemistry biophysical chemistry intrinsically disordered proteins


Titolo Ordina per citazioni Ordina per anno Ordina per titolo	Citata da Citata da	Anno
Molecular mechanism of the interaction between MDM2 and p53 O Schon, A Friedler, M Bycroft, SMV Freund, AR Fersht Journal of molecular biology 323 (3), 491-501, 2002	456	2002
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants A Friedler, LO Hansson, DB Veprintsev, SMV Freund, TM Rippin, ... Proceedings of the National Academy of Sciences 99 (2), 937-942, 2002	348	2002
Studying protein–protein interactions using peptide arrays C Katz, L Levy-Beladev, S Rotem-Bamberger, T Rito, SGD Rüdiger, ... Chemical Society Reviews 40 (5), 2131-2145, 2011	240	2011
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium Z Hayouka, J Rosenbluh, A Levin, S Loya, M Lebendiker, D Veprintsev, ... Proceedings of the National Academy of Sciences 104 (20), 8316-8321, 2007	234	2007
Butyrylcholinesterase attenuates amyloid fibril formation in vitro S Diamant, E Podoly, A Friedler, H Ligumsky, O Livnah, H Soreq Proceedings of the National Academy of Sciences 103 (23), 8628-8633, 2006	202	2006
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide N Issaeva, A Friedler, P Bozko, KG Wiman, AR Fersht, G Selivanova Proceedings of the National Academy of Sciences 100 (23), 13303-13307, 2003	195	2003
The C terminus of p53 binds the N-terminal domain of MDM2 MV Poyurovsky, C Katz, O Laptenko, R Beckerman, M Lokshin, J Ahn, ... Nature structural & molecular biology 17 (8), 982-989, 2010	178	2010
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules A Friedler, DB Veprintsev, LO Hansson, AR Fersht Journal of Biological Chemistry 278 (26), 24108-24112, 2003	174	2003
Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 LO Hansson, A Friedler, S Freund, S Rüdiger, AR Fersht Proceedings of the National Academy of Sciences 99 (16), 10305-10309, 2002	172	2002
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation D Mayer, FF Damberger, M Samarasimhareddy, M Feldmueller, ... Nature communications 10 (1), 1261, 2019	116	2019
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation A Friedler, DB Veprintsev, SMV Freund, KI von Glos, AR Fersht Structure 13 (4), 629-636, 2005	113	2005
The structure of an FF domain from human HYPA/FBP11 M Allen, A Friedler, O Schon, M Bycroft Journal of molecular biology 323 (3), 411-416, 2002	109	2002
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for “mutant conformation” A Friedler, BS DeDecker, SMV Freund, C Blair, S Rüdiger, AR Fersht Journal of molecular biology 336 (1), 187-196, 2004	89	2004
Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling J Petersen, SC Wright, D Rodríguez, P Matricon, N Lahav, A Vromen, ... Nature communications 8 (1), 226, 2017	86	2017
Chemical synthesis and expression of the HIV‐1 Rev protein P Siman, O Blatt, T Moyal, T Danieli, M Lebendiker, HA Lashuel, ... ChemBioChem 12 (7), 1097-1104, 2011	82	2011
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein Z Hayouka, M Hurevich, A Levin, H Benyamini, A Iosub, M Maes, ... Bioorganic & medicinal chemistry 18 (23), 8388-8395, 2010	81	2010
Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes O Schon, A Friedler, S Freund, AR Fersht Journal of molecular biology 336 (1), 197-202, 2004	78	2004
Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif A Friedler, D Friedler, NW Luedtke, Y Tor, A Loyter, C Gilon Journal of biological chemistry 275 (31), 23783-23789, 2000	78	2000
Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in … A Friedler, N Zakai, O Karni, YC Broder, L Baraz, M Kotler, A Loyter, ... Biochemistry 37 (16), 5616-5622, 1998	78	1998
Observation of signal transduction in three-dimensional domain swapping JWH Schymkowitz, F Rousseau, HR Wilkinson, A Friedler, LS Itzhaki nature structural biology 8 (10), 888-892, 2001	76	2001

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