| Systematic identification of genomic markers of drug sensitivity in cancer cells MJ Garnett, EJ Edelman, SJ Heidorn, CD Greenman, A Dastur, KW Lau, ... Nature 483 (7391), 570-575, 2012 | 1972 | 2012 |
| Prospective derivation of a living organoid biobank of colorectal cancer patients M van de Wetering, HE Francies, JM Francis, G Bounova, F Iorio, A Pronk, ... Cell 161 (4), 933-945, 2015 | 1119 | 2015 |
| Drug repurposing: progress, challenges and recommendations S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ... Nature reviews Drug discovery 18 (1), 41-58, 2019 | 925 | 2019 |
| A landscape of pharmacogenomic interactions in cancer F Iorio, TA Knijnenburg, DJ Vis, GR Bignell, MP Menden, M Schubert, ... Cell 166 (3), 740-754, 2016 | 882 | 2016 |
| Discovery of drug mode of action and drug repositioning from transcriptional responses F Iorio, R Bosotti, E Scacheri, V Belcastro, P Mithbaokar, R Ferriero, ... Proceedings of the National Academy of Sciences 107 (33), 14621-14626, 2010 | 685 | 2010 |
| Heterogeneity of genomic evolution and mutational profiles in multiple myeloma N Bolli, H Avet-Loiseau, DC Wedge, P Van Loo, LB Alexandrov, ... Nature communications 5 (1), 1-13, 2014 | 681 | 2014 |
| A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches I Cantone, L Marucci, F Iorio, MA Ricci, V Belcastro, M Bansal, S Santini, ... Cell 137 (1), 172-181, 2009 | 386 | 2009 |
| Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties MP Menden, F Iorio, M Garnett, U McDermott, CH Benes, PJ Ballester, ... PLoS one 8 (4), e61318, 2013 | 329 | 2013 |
| Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens FM Behan, F Iorio, G Picco, E Gonçalves, CM Beaver, G Migliardi, ... Nature 568 (7753), 511-516, 2019 | 323 | 2019 |
| A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ... Cell reports 17 (4), 1193-1205, 2016 | 314 | 2016 |
| Transcriptional data: a new gateway to drug repositioning? F Iorio, T Rittman, H Ge, M Menden, J Saez-Rodriguez Drug discovery today 18 (7-8), 350-357, 2013 | 188 | 2013 |
| Pharmacogenomic agreement between two cancer cell line data sets Cancer Cell Line Encyclopedia Consortium, ... Nature 528 (7580), 84, 2015 | 186 | 2015 |
| Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis M Petljak, LB Alexandrov, JS Brammeld, S Price, DC Wedge, ... Cell 176 (6), 1282-1294. e20, 2019 | 135 | 2019 |
| BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model D Perna, FA Karreth, AG Rust, PA Perez-Mancera, M Rashid, F Iorio, ... Proceedings of the National Academy of Sciences 112 (6), E536-E545, 2015 | 117 | 2015 |
| Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function V Belcastro, V Siciliano, F Gregoretti, P Mithbaokar, G Dharmalingam, ... Nucleic acids research 39 (20), 8677-8688, 2011 | 106 | 2011 |
| Identifying network of drug mode of action by gene expression profiling F Iorio, R Tagliaferri, D Bernardo Journal of Computational Biology 16 (2), 241-251, 2009 | 98 | 2009 |
| Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ... Leukemia 31 (3), 720-727, 2017 | 80 | 2017 |
| Transcription factor activities enhance markers of drug sensitivity in cancer L Garcia-Alonso, F Iorio, A Matchan, N Fonseca, P Jaaks, G Peat, ... Cancer research 78 (3), 769-780, 2018 | 70 | 2018 |
| Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors P Casado, MP Alcolea, F Iorio, JC Rodríguez-Prados, B Vanhaesebroeck, ... Genome biology 14 (4), 1-18, 2013 | 61 | 2013 |
| DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data C Pacini, F Iorio, E Gonçalves, M Iskar, T Klabunde, P Bork, ... Bioinformatics 29 (1), 132-134, 2013 | 59 | 2013 |
Mathew GarnettWellcome Sanger InstituteVerified email at sanger.ac.uk
