| Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. M Baba, S Nakajo, PH Tu, T Tomita, K Nakaya, VM Lee, JQ Trojanowski, ... The American journal of pathology 152 (4), 879, 1998 | 2072 | 1998 |
| APP processing and synaptic function F Kamenetz, T Tomita, H Hsieh, G Seabrook, D Borchelt, T Iwatsubo, ... Neuron 37 (6), 925-937, 2003 | 2062 | 2003 |
| High performance plasma amyloid-β biomarkers for Alzheimer’s disease A Nakamura, N Kaneko, VL Villemagne, T Kato, J Doecke, V Doré, ... Nature 554 (7691), 249-254, 2018 | 1449 | 2018 |
| AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss H Hsieh, J Boehm, C Sato, T Iwatsubo, T Tomita, S Sisodia, R Malinow Neuron 52 (5), 831-843, 2006 | 1326 | 2006 |
| The role of presenilin cofactors in the γ-secretase complex N Takasugi, T Tomita, I Hayashi, M Tsuruoka, M Niimura, Y Takahashi, ... Nature 422 (6930), 438-441, 2003 | 1163 | 2003 |
| Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein P Tu, JE Galvin, M Baba, B Giasson, T Tomita, S Leight, S Nakajo, ... Annals of neurology 44 (3), 415-422, 1998 | 740 | 1998 |
| Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating KH Cheung, D Shineman, M Müller, C Cardenas, L Mei, J Yang, T Tomita, ... Neuron 58 (6), 871-883, 2008 | 526 | 2008 |
| Structures of α-synuclein filaments from multiple system atrophy M Schweighauser, Y Shi, A Tarutani, F Kametani, AG Murzin, B Ghetti, ... Nature 585 (7825), 464-469, 2020 | 512 | 2020 |
| The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue T Tomita, K Maruyama, TC Saido, H Kume, K Shinozaki, S Tokuhiro, ... Proceedings of the National Academy of Sciences 94 (5), 2025-2030, 1997 | 508 | 1997 |
| Effects of PS1 deficiency on membrane protein trafficking in neurons S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita, T Iwatsubo, X Qian, ... Neuron 21 (5), 1213-1221, 1998 | 476 | 1998 |
| A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signaling H Steiner, K Duff, A Capell, H Romig, MG Grim, S Lincoln, J Hardy, X Yu, ... Journal of Biological Chemistry 274 (40), 28669-28673, 1999 | 411 | 1999 |
| Neprilysin degrades both amyloid β peptides 1–40 and 1–42 most rapidly and efficiently among thiorphan-and phosphoramidon-sensitive endopeptidases K Shirotani, S Tsubuki, N Iwata, Y Takaki, W Harigaya, K Maruyama, ... Journal of Biological Chemistry 276 (24), 21895-21901, 2001 | 354 | 2001 |
| Presenilins mediate a dual intramembranous γ‐secretase cleavage of Notch‐1 M Okochi, H Steiner, A Fukumori, H Tanii, T Tomita, T Tanaka, T Iwatsubo, ... The EMBO journal, 2002 | 328 | 2002 |
| A presenilin dimer at the core of the γ-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis EH Schroeter, MXG Ilagan, AL Brunkan, S Hecimovic, Y Li, M Xu, ... Proceedings of the National Academy of Sciences 100 (22), 13075-13080, 2003 | 263 | 2003 |
| Sulindac sulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aβ42 generation Y Takahashi, I Hayashi, Y Tominari, K Rikimaru, Y Morohashi, T Kan, ... Journal of Biological Chemistry 278 (20), 18664-18670, 2003 | 262 | 2003 |
| BACE1 activity is modulated by cell-associated sphingosine-1-phosphate N Takasugi, T Sasaki, K Suzuki, S Osawa, H Isshiki, Y Hori, N Shimada, ... Journal of Neuroscience 31 (18), 6850-6857, 2011 | 227 | 2011 |
| C-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT (N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl … Y Morohashi, T Kan, Y Tominari, H Fuwa, Y Okamura, N Watanabe, ... Journal of Biological Chemistry 281 (21), 14670-14676, 2006 | 226 | 2006 |
| Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease M Takahashi, S Doré, CD Ferris, T Tomita, A Sawa, H Wolosker, ... Neuron 28 (2), 461-473, 2000 | 220 | 2000 |
| Activity-dependent proteolytic cleavage of neuroligin-1 K Suzuki, Y Hayashi, S Nakahara, H Kumazaki, J Prox, K Horiuchi, ... Neuron 76 (2), 410-422, 2012 | 217 | 2012 |
| Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44 D Murakami, I Okamoto, O Nagano, Y Kawano, T Tomita, T Iwatsubo, ... Oncogene 22 (10), 1511-1516, 2003 | 200 | 2003 |
Takeshi IwatsuboProfessor of Neuropathology, The University of TokyoVerified email at m.u-tokyo.ac.jp
