NPE Vermeulen
NPE Vermeulen
Hoogleraar VU
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Citata da
Citata da
Fish bioaccumulation and biomarkers in environmental risk assessment: a review
R Van der Oost, J Beyer, NPE Vermeulen
Environmental toxicology and pharmacology 13 (2), 57-149, 2003
Membrane transporters in drug development
KM Giacomini, SM Huang, DJ Tweedie, LZ Benet, KLR Brouwer, X Chu, ...
Nature reviews Drug discovery 9 (3), 215, 2010
Biomarkers of free radical damage: applications in experimental animals and in humans
LL de Zwart, JHN Meerman, JNM Commandeur, NPE Vermeulen
Free Radical Biology and Medicine 26 (1-2), 202-226, 1999
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches
JGM Bessems, NPE Vermeulen
Critical reviews in toxicology 31 (1), 55-138, 2001
Enzyme-catalyzed activation of anticancer prodrugs
M Rooseboom, JNM Commandeur, NPE Vermeulen
Pharmacological reviews 56 (1), 53-102, 2004
Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics
JNM Commandeur
Pharmacol Rev. 47, 271-330, 1995
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention
NPE Vermeulen, JGM Bessems, R Van de Straat
Drug metabolism reviews 24 (3), 367-407, 1992
Genetic Polymorphisms of Human N-Acetyltransferase, Cytochrome P450, Glutathione-S-Transferase, and Epoxide Hydrolase Enzymes: Relevance to Xenobiotic …
LW Wormhoudt, JNM Commandeur, NPE Vermeulen
Critical reviews in toxicology 29 (1), 59-124, 1999
Managing the challenge of chemically reactive metabolites in drug development
BK Park, A Boobis, S Clarke, CEP Goldring, D Jones, JG Kenna, ...
Nature Reviews Drug Discovery 10 (4), 292-306, 2011
Oxygen and xenobiotic reductase activities of cytochrome P450
AR Goeptar, H Scheerens, NPE Vermeulen
Critical reviews in toxicology 25 (1), 25-65, 1995
Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver
S Oetari, M Sudibyo, JNM Commandeur, R Samhoedi, NPE Vermeulen
Biochemical pharmacology 51 (1), 39-45, 1996
Cytochrome P450 in silico: an integrative modeling approach
C De Graaf, NPE Vermeulen, KA Feenstra
Journal of medicinal chemistry 48 (8), 2725-2755, 2005
Biomonitoring of aquatic pollution with feral eel (Anguilla anguilla) II. Biomarkers: pollution-induced biochemical responses
R van der Oost, A Goksøyr, M Celander, H Heida, NPE Vermeulen
Aquatic Toxicology 36 (3-4), 189-222, 1996
Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man
CH Kleinbloesem, P Van Brummelen, H Faber, M Danhof, ...
Biochemical pharmacology 33 (22), 3721-3724, 1984
A predictive model for substrates of cytochrome P450-debrisoquine (2D6)
L Koymans, NPE Vermeulen, SABE Van Acker, JM Te Koppele, ...
Chemical research in toxicology 5 (2), 211-219, 1992
Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals
RTH van Welie, RGJM van Dijck, NPE Vermeulen, NJ van Sittert
Critical reviews in toxicology 22 (5-6), 271-306, 1992
Cytotoxic and cytoprotective activities of curcumin: effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes
IA Donatus, NPE Vermeulen
Biochemical pharmacology 39 (12), 1869-1875, 1990
Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products
R Appiah-Opong, JNM Commandeur, B van Vugt-Lussenburg, ...
Toxicology 235 (1-2), 83-91, 2007
The role of water molecules in computational drug design
S de Beer, NPE Vermeulen, C Oostenbrink
Current topics in medicinal chemistry 10 (1), 55-66, 2010
Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking
C de Graaf, C Oostenbrink, PHJ Keizers, T van der Wijst, A Jongejan, ...
Journal of medicinal chemistry 49 (8), 2417-2430, 2006
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