Chris Langmead
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Agonist-bound adenosine A 2A receptor structures reveal common features of GPCR activation
G Lebon, T Warne, PC Edwards, K Bennett, CJ Langmead, AGW Leslie, ...
Nature 474 (7352), 521-525, 2011
Muscarinic acetylcholine receptors as CNS drug targets
CJ Langmead, J Watson, C Reavill
Pharmacology & therapeutics 117 (2), 232-243, 2008
Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design
M Congreve, SP Andrews, AS Doré, K Hollenstein, E Hurrell, ...
Journal of medicinal chemistry 55 (5), 1898-1903, 2012
Progress in structure based drug design for G protein-coupled receptors
M Congreve, CJ Langmead, JS Mason, FH Marshall
Journal of medicinal chemistry 54 (13), 4283-4311, 2011
Characterisation of the binding of [3H]‐SB‐674042, a novel nonpeptide antagonist, to the human orexin‐1 receptor
CJ Langmead, JC Jerman, SJ Brough, C Scott, RA Porter, HJ Herdon
British journal of pharmacology 141 (2), 340-346, 2004
International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands
A Christopoulos, JP Changeux, WA Catterall, D Fabbro, TP Burris, ...
Pharmacological reviews 66 (4), 918-947, 2014
The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery
N Robertson, A Jazayeri, J Errey, A Baig, E Hurrell, A Zhukov, ...
Neuropharmacology 60 (1), 36-44, 2011
Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox
CJ Langmead, A Christopoulos
Trends in pharmacological sciences 27 (9), 475-481, 2006
Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone
ZA Hughes, KR Starr, CJ Langmead, M Hill, GD Bartoszyk, JJ Hagan, ...
European journal of pharmacology 510 (1-2), 49-57, 2005
Identification of Novel Adenosine A2A Receptor Antagonists by Virtual Screening
CJ Langmead, SP Andrews, M Congreve, JC Errey, E Hurrell, ...
Journal of medicinal chemistry 55 (5), 1904-1909, 2012
Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors
LT May, VA Avlani, CJ Langmead, HJ Herdon, MD Wood, PM Sexton, ...
Molecular pharmacology 72 (2), 463-476, 2007
Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: direct pharmacological …
CJ Langmead, VAH Fry, IT Forbes, CL Branch, A Christopoulos, ...
Molecular pharmacology 69 (1), 236-246, 2006
Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1
CJ Langmead, NE Austin, CL Branch, JT Brown, KA Buchanan, ...
British journal of pharmacology 154 (5), 1104-1115, 2008
Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor
VA Avlani, CJ Langmead, E Guida, MD Wood, BG Tehan, HJ Herdon, ...
Molecular pharmacology 78 (1), 94-104, 2010
G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists
RL Thomas, R Mistry, CJ Langmead, MD Wood, RAJ Challiss
Journal of Pharmacology and Experimental Therapeutics 327 (2), 365-374, 2008
Neurochemical changes in LPA 1 receptor deficient mice–A putative model of schizophrenia
C Roberts, P Winter, CS Shilliam, ZA Hughes, C Langmead, PR Maycox, ...
Neurochemical research 30 (3), 371-377, 2005
Binding kinetics differentiates functional antagonism of orexin‐2 receptor ligands
R Mould, J Brown, FH Marshall, CJ Langmead
British journal of pharmacology 171 (2), 351-363, 2014
Characterization of the binding of [125I]‐human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor
CJ Langmead, PG Szekeres, JK Chambers, SJ Ratcliffe, DNC Jones, ...
British journal of pharmacology 131 (4), 683-688, 2000
Pharmacology and structure of isolated conformations of the adenosine A2A receptor define ligand efficacy
KA Bennett, B Tehan, G Lebon, CG Tate, M Weir, FH Marshall, ...
Molecular pharmacology 83 (5), 949-958, 2013
Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro
DW Jenkins, CJ Langmead, AA Parsons, PJ Strijbos
Neuroscience letters 366 (3), 241-244, 2004
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