Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior D Goswami, D Chen, Y Yang, PR Gudla, J Columbus, K Worthy, M Rigby, ... Elife 9, e47654, 2020 | 24 | 2020 |
Virtual screening for small-molecule pathway regulators by image-profile matching MH Rohban, AM Fuller, C Tan, JT Goldstein, D Syangtan, A Gutnick, ... Cell systems 13 (9), 724-736. e9, 2022 | 20 | 2022 |
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling AC Nelson, TJ Turbyville, S Dharmaiah, M Rigby, R Yang, TY Wang, ... Journal of Biological Chemistry 295 (28), 9335-9348, 2020 | 11 | 2020 |
Detection and verification of 2.3 million cancer mutations in NCI60 cancer cell lines with a cloud search engine A Prakash, S Majumder, S Ahmad, M Varkey, TA Anish, C Jenkins, ... Journal of proteomics 209, 103488, 2019 | 9 | 2019 |
High-Throughput Cell-Based Screening of Small Molecule KRAS Signaling Inhibitors Using a Homogeneous Time-Resolved Fluorescence (HTRF) Assay BP Smith, M Rigby, R Ma, AE Maciag KRAS: Methods and Protocols, 271-285, 2024 | | 2024 |
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties MJ Whitley, TH Tran, M Rigby, M Yi, S Dharmaiah, TJ Waybright, ... Science Advances 10 (7), eadj4137, 2024 | | 2024 |
Abstract A033: KRAS codon 12 oncogenic mutations modulate protein conformation within the Switch II/Helix3 pocket B Smith, AK Sharma, R Ma, M Rigby, V Kumari, D Esposito, D Nissley, ... Molecular Cancer Research 21 (5_Supplement), A033-A033, 2023 | | 2023 |
Abstract B027: Bioluminescence resonance energy transfer (BRET) as a tool for assessing mutant KRAS-effector affinity and drug efficacy M Rigby, J Columbus, V Wall, D Esposito, T Turbyville, D Simanshu, ... Molecular Cancer Research 21 (5_Supplement), B027-B027, 2023 | | 2023 |
Characterization of effector binding preferences between oncogenic mutants KRAS4b G12D and KRAS4b G12C M Rigby Hood College, 2023 | | 2023 |
Interrogating RAS isoform and mutational specificity for effectors with bioluminescence resonance energy transfer (BRET) M Rigby, J Columbus, V Wall, D Esposito, T Turbyville Cancer Research 81 (13_Supplement), 2272-2272, 2021 | | 2021 |
RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling AC Nelson, T Turbyville, S Dharmaiah, M Rigby, R Yang, J Columbus, ... bioRxiv, 737098, 2019 | | 2019 |