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Megan Rigby
Megan Rigby
Frederick National Laboratory for Cancer Research
Verified email at nih.gov
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Cited by
Cited by
Year
Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior
D Goswami, D Chen, Y Yang, PR Gudla, J Columbus, K Worthy, M Rigby, ...
Elife 9, e47654, 2020
242020
Virtual screening for small-molecule pathway regulators by image-profile matching
MH Rohban, AM Fuller, C Tan, JT Goldstein, D Syangtan, A Gutnick, ...
Cell systems 13 (9), 724-736. e9, 2022
202022
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling
AC Nelson, TJ Turbyville, S Dharmaiah, M Rigby, R Yang, TY Wang, ...
Journal of Biological Chemistry 295 (28), 9335-9348, 2020
112020
Detection and verification of 2.3 million cancer mutations in NCI60 cancer cell lines with a cloud search engine
A Prakash, S Majumder, S Ahmad, M Varkey, TA Anish, C Jenkins, ...
Journal of proteomics 209, 103488, 2019
92019
High-Throughput Cell-Based Screening of Small Molecule KRAS Signaling Inhibitors Using a Homogeneous Time-Resolved Fluorescence (HTRF) Assay
BP Smith, M Rigby, R Ma, AE Maciag
KRAS: Methods and Protocols, 271-285, 2024
2024
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties
MJ Whitley, TH Tran, M Rigby, M Yi, S Dharmaiah, TJ Waybright, ...
Science Advances 10 (7), eadj4137, 2024
2024
Abstract A033: KRAS codon 12 oncogenic mutations modulate protein conformation within the Switch II/Helix3 pocket
B Smith, AK Sharma, R Ma, M Rigby, V Kumari, D Esposito, D Nissley, ...
Molecular Cancer Research 21 (5_Supplement), A033-A033, 2023
2023
Abstract B027: Bioluminescence resonance energy transfer (BRET) as a tool for assessing mutant KRAS-effector affinity and drug efficacy
M Rigby, J Columbus, V Wall, D Esposito, T Turbyville, D Simanshu, ...
Molecular Cancer Research 21 (5_Supplement), B027-B027, 2023
2023
Characterization of effector binding preferences between oncogenic mutants KRAS4b G12D and KRAS4b G12C
M Rigby
Hood College, 2023
2023
Interrogating RAS isoform and mutational specificity for effectors with bioluminescence resonance energy transfer (BRET)
M Rigby, J Columbus, V Wall, D Esposito, T Turbyville
Cancer Research 81 (13_Supplement), 2272-2272, 2021
2021
RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling
AC Nelson, T Turbyville, S Dharmaiah, M Rigby, R Yang, J Columbus, ...
bioRxiv, 737098, 2019
2019
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