| Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche F Arai, A Hirao, M Ohmura, H Sato, S Matsuoka, K Takubo, K Ito, GY Koh, ... Cell 118 (2), 149-161, 2004 | 2489 | 2004 |
| Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells K Ito, A Hirao, F Arai, K Takubo, S Matsuoka, K Miyamoto, M Ohmura, ... Nature medicine 12 (4), 446-451, 2006 | 1529 | 2006 |
| Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells K Ito, A Hirao, F Arai, S Matsuoka, K Takubo, I Hamaguchi, K Nomiyama, ... Nature 431 (7011), 997-1002, 2004 | 1359 | 2004 |
| Regulation of the HIF-1α level is essential for hematopoietic stem cells K Takubo, N Goda, W Yamada, H Iriuchishima, E Ikeda, Y Kubota, ... Cell stem cell 7 (3), 391-402, 2010 | 1019 | 2010 |
| Foxo3a is essential for maintenance of the hematopoietic stem cell pool K Miyamoto, KY Araki, K Naka, F Arai, K Takubo, S Yamazaki, S Matsuoka, ... Cell stem cell 1 (1), 101-112, 2007 | 983 | 2007 |
| Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche H Yoshihara, F Arai, K Hosokawa, T Hagiwara, K Takubo, Y Nakamura, ... Cell stem cell 1 (6), 685-697, 2007 | 951 | 2007 |
| Metabolic regulation of hematopoietic stem cells in the hypoxic niche T Suda, K Takubo, GL Semenza Cell stem cell 9 (4), 298-310, 2011 | 892 | 2011 |
| Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells K Takubo, G Nagamatsu, CI Kobayashi, A Nakamura-Ishizu, H Kobayashi, ... Cell stem cell 12 (1), 49-61, 2013 | 818 | 2013 |
| M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis Y Kubota, K Takubo, T Shimizu, H Ohno, K Kishi, M Shibuya, H Saya, ... Journal of Experimental Medicine 206 (5), 1089-1102, 2009 | 447 | 2009 |
| Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells T Koto, K Takubo, S Ishida, H Shinoda, M Inoue, K Tsubota, Y Okada, ... The American journal of pathology 170 (4), 1389-1397, 2007 | 294 | 2007 |
| Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL S Matsuoka, Y Oike, I Onoyama, A Iwama, F Arai, K Takubo, Y Mashimo, ... Genes & development 22 (8), 986-991, 2008 | 211 | 2008 |
| Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification K Morita, T Miyamoto, N Fujita, Y Kubota, K Ito, K Takubo, K Miyamoto, ... The Journal of experimental medicine 204 (7), 1613-1623, 2007 | 203 | 2007 |
| Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration S Suzuki, N Fujita, N Hosogane, K Watanabe, K Ishii, Y Toyama, ... Arthritis research & therapy 17, 1-17, 2015 | 202 | 2015 |
| Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7 A Nagamachi, H Matsui, H Asou, Y Ozaki, D Aki, A Kanai, K Takubo, ... Cancer cell 24 (3), 305-317, 2013 | 197 | 2013 |
| Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche Y Kubota, K Takubo, T Suda Biochemical and biophysical research communications 366 (2), 335-339, 2008 | 180 | 2008 |
| Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin A Nakamura-Ishizu, K Takubo, M Fujioka, T Suda Biochemical and biophysical research communications 454 (2), 353-357, 2014 | 158 | 2014 |
| Fasting-refeeding impacts immune cell dynamics and mucosal immune responses M Nagai, R Noguchi, D Takahashi, T Morikawa, K Koshida, S Komiyama, ... Cell 178 (5), 1072-1087. e14, 2019 | 157 | 2019 |
| Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest K Takubo, M Ohmura, M Azuma, G Nagamatsu, W Yamada, F Arai, ... Cell stem cell 2 (2), 170-182, 2008 | 141 | 2008 |
| Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes K Ito, K Takubo, F Arai, H Satoh, S Matsuoka, M Ohmura, K Naka, ... The Journal of Immunology 178 (1), 103-110, 2007 | 133 | 2007 |
| Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow K Hosokawa, F Arai, H Yoshihara, H Iwasaki, M Hembree, T Yin, ... Cell stem cell 6 (3), 194-198, 2010 | 125 | 2010 |
Toshio SudaCSI, National University of Singapore, IRCMS Kumamoto UniversityVerified email at kumamoto-u.ac.jp
