Laurent Chiarelli
Laurent Chiarelli
Department of Biology and Biotechnology, University of Pavia
Email verificata su - Home page
Citata da
Citata da
The allosteric regulation of pyruvate kinase: a site-directed mutagenesis study
G Valentini, L Chiarelli, R Fortin, ML Speranza, A Galizzi, A Mattevi
Journal of Biological Chemistry 275 (24), 18145-18152, 2000
ThermoFAD, a Thermofluor®‐adapted flavin ad hoc detection system for protein folding and ligand binding
F Forneris, R Orru, D Bonivento, LR Chiarelli, A Mattevi
The FEBS journal 276 (10), 2833-2840, 2009
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis
J Neres, F Pojer, E Molteni, LR Chiarelli, N Dhar, S Boy-Röttger, S Buroni, ...
Science translational medicine 4 (150), 150ra121-150ra121, 2012
Pyruvate kinase deficiency: the genotype-phenotype association
A Zanella, E Fermo, P Bianchi, LR Chiarelli, G Valentini
Blood reviews 21 (4), 217-231, 2007
Structure and function of human erythrocyte pyruvate kinase: molecular basis of nonspherocytic hemolytic anemia
G Valentini, LR Chiarelli, R Fortin, M Dolzan, A Galizzi, DJ Abraham, ...
Journal of Biological Chemistry 277 (26), 23807-23814, 2002
Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches
VC Scoffone, LR Chiarelli, G Trespidi, M Mentasti, G Riccardi, S Buroni
Frontiers in microbiology 8, 1592, 2017
Helicobacter pyloril-asparaginase: a promising chemotherapeutic agent
D Cappelletti, LR Chiarelli, MV Pasquetto, S Stivala, G Valentini, C Scotti
Biochemical and biophysical research communications 377 (4), 1222-1226, 2008
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1
J Neres, RC Hartkoorn, LR Chiarelli, R Gadupudi, MR Pasca, G Mori, ...
ACS chemical biology 10 (3), 705-714, 2015
Expanding targets for a metabolic therapy of cancer: L-asparaginase
D Covini, S Tardito, O Bussolati, L R Chiarelli, M V Pasquetto, R Digilio, ...
Recent patents on anti-cancer drug discovery 7 (1), 4-13, 2012
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis
G Riccardi, MR Pasca, LR Chiarelli, G Manina, A Mattevi, C Binda
Applied microbiology and biotechnology 97, 8841-8848, 2013
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance
G Manina, M Bellinzoni, MR Pasca, J Neres, A Milano, ...
Molecular microbiology 77 (5), 1172-1185, 2010
4-Aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity
M Naik, V Humnabadkar, SJ Tantry, M Panda, A Narayan, S Guptha, ...
Journal of medicinal chemistry 57 (12), 5419-5434, 2014
Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients
G Degiacomi, JC Sammartino, LR Chiarelli, O Riabova, V Makarov, ...
International journal of molecular sciences 20 (23), 5868, 2019
Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms
M Bovi, ME Carrizo, S Capaldi, M Perduca, LR Chiarelli, M Galliano, ...
Glycobiology 21 (8), 1000-1009, 2011
Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase
M Tortorici, MT Borrello, M Tardugno, LR Chiarelli, S Pilotto, G Ciossani, ...
ACS chemical biology 8 (8), 1677-1682, 2013
Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency
LR Chiarelli, SM Morera, P Bianchi, E Fermo, A Zanella, A Galizzi, ...
PLOS one 7 (2), e32065, 2012
Mechanochemical synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity
PFM Oliveira, B Guidetti, A Chamayou, C André-Barrès, J Madacki, ...
Molecules 22 (9), 1457, 2017
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG
G Mori, LR Chiarelli, M Esposito, V Makarov, M Bellinzoni, RC Hartkoorn, ...
Chemistry & biology 22 (7), 917-927, 2015
BEL β-trefoil: A novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms
M Bovi, L Cenci, M Perduca, S Capaldi, ME Carrizo, L Civiero, ...
Glycobiology 23 (5), 578-592, 2013
Cell-cycle inhibition by Helicobacter pylori L-asparaginase
C Scotti, P Sommi, MV Pasquetto, D Cappelletti, S Stivala, P Mignosi, ...
PloS one 5 (11), e13892, 2010
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