Erik van den Akker
Erik van den Akker
Molecular Epidemiology Leiden University Medical Centre
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Citata da
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Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ...
Aging cell 10 (4), 686-698, 2011
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
J Deelen, M Beekman, HW Uh, L Broer, KL Ayers, Q Tan, Y Kamatani, ...
Human molecular genetics 23 (16), 4420-4432, 2014
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
RC Slieker, SD Bos, JJ Goeman, JVMG Bovée, RP Talens, ...
Epigenetics & chromatin 6 (1), 1-12, 2013
Genome‐wide linkage analysis for human longevity: genetics of healthy aging study
M Beekman, H Blanché, M Perola, A Hervonen, V Bezrukov, E Sikora, ...
Aging cell 12 (2), 184-193, 2013
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
J Deelen, HW Uh, R Monajemi, D van Heemst, PE Thijssen, S Böhringer, ...
Age 35 (1), 235-249, 2013
Genomics of human longevity
PE Slagboom, M Beekman, WM Passtoors, J Deelen, AAM Vaarhorst, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 366 …, 2011
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis
N Bomer, W den Hollander, YFM Ramos, SD Bos, R van der Breggen, ...
Annals of the rheumatic diseases 74 (8), 1571-1579, 2015
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R
WM Passtoors, JM Boer, JJ Goeman, EB van den Akker, J Deelen, ...
PLoS one 7 (1), e27759, 2012
Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice
F Rusli, J Deelen, E Andriyani, MV Boekschoten, C Lute, ...
Scientific reports 6, 30484, 2016
Human plasma N-glycosylation as analyzed by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance-MS associates with markers of inflammation and …
KR Reiding, LR Ruhaak, HW Uh, S El Bouhaddani, EB van den Akker, ...
Molecular & Cellular Proteomics 16 (2), 228-242, 2017
Meta‐analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging
EB van den Akker, WM Passtoors, R Jansen, EW van Zwet, JJ Goeman, ...
Aging cell 13 (2), 216-225, 2014
Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis
E van den Akker, B Verbruggen, B Heijmans, M Beekman, J Kok, ...
Journal of Integrative Bioinformatics 8 (2), 222-238, 2011
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
J Deelen, J Kettunen, K Fischer, A van der Spek, S Trompet, ...
Nature communications 10 (1), 1-8, 2019
Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2
EB van den Akker, SJ Pitts, J Deelen, MH Moed, S Potluri, J Van Rooij, ...
Blood, The Journal of the American Society of Hematology 127 (11), 1512-1515, 2016
Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs
K Ye, M Beekman, EW Lameijer, Y Zhang, MH Moed, EB van den Akker, ...
Twin Research and Human Genetics 16 (6), 1026-1032, 2013
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the …
SJ van der Lee, OJ Conway, I Jansen, MM Carrasquillo, L Kleineidam, ...
Acta neuropathologica 138 (2), 237-250, 2019
Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics
E Taskesen, SMH Huisman, A Mahfouz, JH Krijthe, J De Ridder, ...
Scientific reports 6 (1), 1-14, 2016
Genome-wide association study on immunoglobulin G glycosylation patterns
A Wahl, E van den Akker, L Klaric, J Štambuk, E Benedetti, R Plomp, ...
Frontiers in immunology 9, 277, 2018
A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention
ML Sampietro, S Trompet, JJW Verschuren, RP Talens, J Deelen, ...
Human molecular genetics 20 (23), 4748-4757, 2011
IL7R gene expression network associates with human healthy ageing
WM Passtoors, EB van den Akker, J Deelen, AB Maier, ...
Immunity & ageing 12 (1), 1-9, 2015
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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