|Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia|
T Palomero, ML Sulis, M Cortina, PJ Real, K Barnes, M Ciofani, ...
Nature medicine 13 (10), 1203, 2007
|A validated regulatory network for Th17 cell specification|
M Ciofani, A Madar, C Galan, ML Sellars, K Mace, F Pauli, A Agarwal, ...
Cell 151 (2), 289-303, 2012
|Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism|
M Ciofani, JC Zuniga-Pflücker
Nature immunology 6 (9), 881, 2005
|Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity|
JR Huh, MWL Leung, P Huang, DA Ryan, MR Krout, RRV Malapaka, ...
Nature 472 (7344), 486, 2011
|Maintenance of T cell specification and differentiation requires recurrent notch receptor–ligand interactions|
TM Schmitt, M Ciofani, HT Petrie, JC Zúñiga-Pflücker
Journal of Experimental Medicine 200 (4), 469-479, 2004
|Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation|
M Ciofani, TM Schmitt, A Ciofani, AM Michie, N Çuburu, A Aublin, ...
The Journal of Immunology 172 (9), 5230-5239, 2004
|Stage-specific and differential notch dependency at the αβ and γδ T lineage bifurcation|
M Ciofani, GC Knowles, DL Wiest, H von Boehmer, JC Zúñiga-Pflücker
Immunity 25 (1), 105-116, 2006
|The thymus as an inductive site for T lymphopoiesis|
M Ciofani, JC Zuniga-Pfluecker
Annu. Rev. Cell Dev. Biol. 23, 463-493, 2007
|A genomic regulatory element that directs assembly and function of immune-specific AP-1–IRF complexes|
E Glasmacher, S Agrawal, AB Chang, TL Murphy, W Zeng, B Vander Lugt, ...
Science 338 (6109), 975-980, 2012
|Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death|
H Okada, C Bakal, A Shahinian, A Elia, A Wakeham, WK Suh, GS Duncan, ...
Journal of Experimental Medicine 199 (3), 399-410, 2004
|The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival|
M Mandal, C Borowski, T Palomero, AA Ferrando, P Oberdoerffer, F Meng, ...
Journal of Experimental Medicine 201 (4), 603-614, 2005
|Marked induction of the helix-loop-helix protein Id3 promotes the γδ T cell fate and renders their functional maturation Notch independent|
JPH Lauritsen, GW Wong, SY Lee, JM Lefebvre, M Ciofani, M Rhodes, ...
Immunity 31 (4), 565-575, 2009
|Determining γδ versus αβ T cell development|
M Ciofani, JC Zúñiga-Pflücker
Nature Reviews Immunology 10 (9), 657, 2010
|Dynamic microRNA gene transcription and processing during T cell development|
FF Kirigin, K Lindstedt, M Sellars, M Ciofani, SL Low, L Jones, F Bell, ...
The Journal of Immunology 188 (7), 3257-3267, 2012
|Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells|
MC Haks, SM Belkowski, M Ciofani, M Rhodes, JM Lefebvre, S Trop, ...
The Journal of Immunology 170 (6), 2853-2861, 2003
|Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells|
MMW Chong, N Simpson, M Ciofani, G Chen, A Collins, DR Littman
Genes & development 24 (7), 659-669, 2010
|A survival guide to early T cell development|
M Ciofani, JC Zúñiga-Pflücker
Immunologic research 34 (2), 117-132, 2006
|Constitutive Notch signalling promotes CD4−CD8− thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals|
AM Michie, AC Chan, M Ciofani, M Carleton, JM Lefebvre, Y He, ...
International immunology 19 (12), 1421-1430, 2007
|JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation|
TM Carr, JD Wheaton, GM Houtz, M Ciofani
Nature communications 8 (1), 301, 2017
|Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the β-selection checkpoint|
EK Koltsova, M Ciofani, R Benezra, T Miyazaki, N Clipstone, ...
The Journal of Immunology 179 (7), 4694-4703, 2007