| Ligand-induced dimerization of Middle East respiratory syndrome (MERS) coronavirus nsp5 protease (3CLpro): implications for nsp5 regulation and the development of antivirals S Tomar, ML Johnston, SES John, HL Osswald, PR Nyalapatla, LN Paul, ... Journal of Biological Chemistry 290 (32), 19403-19422, 2015 | 153 | 2015 |
| Design and development of highly potent HIV-1 protease inhibitors with a crown-like oxotricyclic core as the P2-ligand to combat multidrug-resistant HIV variants AK Ghosh, KV Rao, PR Nyalapatla, HL Osswald, CD Martyr, M Aoki, ... Journal of medicinal chemistry 60 (10), 4267-4278, 2017 | 77 | 2017 |
| Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate DR Fandrick, JT Reeves, JM Bakonyi, PR Nyalapatla, Z Tan, O Niemeier, ... The Journal of Organic Chemistry 78 (8), 3592-3615, 2013 | 57 | 2013 |
| Highly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein–Ligand X-ray Studies AK Ghosh, GL Parham, CD Martyr, PR Nyalapatla, HL Osswald, ... Journal of medicinal chemistry 56 (17), 6792-6802, 2013 | 51 | 2013 |
| A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency M Aoki, H Hayashi, KV Rao, D Das, N Higashi-Kuwata, H Bulut, ... Elife 6, e28020, 2017 | 47 | 2017 |
| Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants AK Ghosh, KV Rao, PR Nyalapatla, S Kovela, M Brindisi, HL Osswald, ... ChemMedChem 13 (8), 803-815, 2018 | 39 | 2018 |
| Design and synthesis of highly potent HIV-1 protease inhibitors containing tricyclic fused ring systems as novel P2 ligands: structure–activity studies, biological and x-ray … AK Ghosh, P R. Nyalapatla, S Kovela, KV Rao, M Brindisi, HL Osswald, ... Journal of medicinal chemistry 61 (10), 4561-4577, 2018 | 33 | 2018 |
| X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design SES John, MD Therkelsen, PR Nyalapatla, HL Osswald, AK Ghosh, ... Bioorganic & medicinal chemistry letters 25 (22), 5072-5077, 2015 | 27 | 2015 |
| Enantioselective Total Synthesis of (+)-Amphirionin-4 AK Ghosh, PR Nyalapatla Organic letters 18 (9), 2296-2299, 2016 | 20 | 2016 |
| Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 … AK Ghosh, M Brindisi, PR Nyalapatla, J Takayama, JR Ella-Menye, ... Bioorganic & medicinal chemistry 25 (19), 5114-5127, 2017 | 16 | 2017 |
| Halogen bond interactions of novel HIV-1 protease inhibitors (PI)(GRL-001-15 and GRL-003-15) with the flap of protease are critical for their potent activity against wild-type … S Hattori, H Hayashi, H Bulut, KV Rao, PR Nyalapatla, K Hasegawa, ... Antimicrobial Agents and Chemotherapy 63 (6), 10.1128/aac. 02635-18, 2019 | 15 | 2019 |
| A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a … M Amano, Y Tojo, PM Salcedo-Gómez, GL Parham, PR Nyalapatla, ... Antimicrobial agents and chemotherapy 59 (5), 2625-2635, 2015 | 14 | 2015 |
| A New Synthesis of Gefitinib PW Taber S. Maskrey, Tyler Kristufek, Matthew G. LaPorte, Prasanth R. Nyalapatla Synlett 30 (04), 471-476, 2019 | 13* | 2019 |
| Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity H Bulut, S Hattori, H Aoki-Ogata, H Hayashi, D Das, M Aoki, DA Davis, ... Scientific Reports 10 (1), 10664, 2020 | 12 | 2020 |
| Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands AK Ghosh, CD Martyr, LA Kassekert, PR Nyalapatla, M Steffey, ... Organic & biomolecular chemistry 13 (48), 11607-11621, 2015 | 11 | 2015 |
| Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans AK Ghosh, PR Nyalapatla Tetrahedron 73 (14), 1820-1830, 2017 | 9 | 2017 |
| Fluorescent probes for monitoring serine ubiquitination K Puvar, AM Saleh, RW Curtis, Y Zhou, P R. Nyalapatla, J Fu, AR Rovira, ... Biochemistry 59 (13), 1309-1313, 2020 | 7 | 2020 |
| Co (II)‐salen catalyzed stereoselective cyclopropanation of fluorinated styrenes S Tai, TS Maskrey, PR Nyalapatla, P Wipf Chirality 31 (12), 1014-1027, 2019 | 4 | 2019 |
| OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence M De Rosa, RP Barnes, PR Nyalapatla, P Wipf, PL Opresko bioRxiv, 2023 | 1 | 2023 |
| Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS AK Ghosh, H Mitsuya, PR Nyalapatla US Patent 11,028,096, 2021 | 1 | 2021 |
