Dean Singleton
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Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ...
Journal of the American Chemical Society 136 (26), 9308-9319, 2014
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia
T Rzymski, M Milani, DC Singleton, AL Harris
Cell cycle 8 (23), 3838-3847, 2009
LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor
PGK Clark, LCC Vieira, C Tallant, O Fedorov, DC Singleton, CM Rogers, ...
Angewandte Chemie 127 (21), 6315-6319, 2015
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
LRG Pike, DC Singleton, F Buffa, O Abramczyk, K Phadwal, JL Li, ...
Biochemical Journal 449 (2), 389-400, 2013
Bystander or no bystander for gene directed enzyme prodrug therapy
GU Dachs, MA Hunt, S Syddall, DC Singleton, AV Patterson
Molecules 14 (11), 4517-4545, 2009
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
EO Pettersen, P Ebbesen, RG Gieling, KJ Williams, L Dubois, P Lambin, ...
Journal of enzyme inhibition and medicinal chemistry 30 (5), 689-721, 2015
Targeting the ATF4 pathway in cancer therapy
DC Singleton, AL Harris
Expert opinion on therapeutic targets 16 (12), 1189-1202, 2012
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
K Kumar, S Wigfield, HE Gee, CM Devlin, D Singleton, JL Li, F Buffa, ...
Journal of molecular medicine 91 (6), 749-758, 2013
Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth
A McIntyre, A Hulikova, I Ledaki, C Snell, D Singleton, G Steers, P Seden, ...
Cancer research 76 (13), 3744-3755, 2016
The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411 NTR
DC Singleton, D Li, SY Bai, SP Syddall, JB Smaill, Y Shen, WA Denny, ...
Cancer gene therapy 14 (12), 953-967, 2007
Method for the fluorescent detection of nitroreductase activity using nitro-substituted aromatic compounds
JB Smaill, AV Patterson, DC Singleton
US Patent App. 12/440,267, 2010
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis
DC Singleton, P Rouhi, CE Zois, S Haider, JL Li, BM Kessler, Y Cao, ...
Oncogene 34 (36), 4713-4722, 2015
Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
DC Singleton, AL Dechaume, PM Murray, WP Katt, BC Baguley, ...
BMC cancer 20, 1-13, 2020
Hypoxia‐Activated Prodrugs of PERK Inhibitors
LP Liew, DC Singleton, WW Wong, GJ Cheng, SMF Jamieson, MP Hay
Chemistry–An Asian Journal 14 (8), 1238-1248, 2019
N-methyl-D-aspartate receptor hypofunction in Meg-01 cells reveals a role for intracellular calcium homeostasis in balancing megakaryocytic-erythroid differentiation
JI Hearn, TN Green, M Chopra, YNS Nursalim, L Ladvanszky, N Knowlton, ...
Thrombosis and haemostasis 120 (4), 671, 2020
Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations
EY Leung, ME Askarian-Amiri, DC Singleton, C Ferraro-Peyret, ...
Frontiers in oncology 8, 425, 2018
Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer
TW Lee, A Lai, JK Harms, DC Singleton, BD Dickson, AMJ Macann, ...
Cancers 12 (12), 3743, 2020
ATF4, hypoxia and treatment resistance in cancer
DC Singleton, AL Harris
The Unfolded Protein Response in Cancer, 75-108, 2019
Microenvironmental induced essentiality of autophagy
DC Singleton, AL Harris
Clinical Cancer Research 19 (11), 2791-2793, 2013
Antitumour efficacy of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR in combination with dinitrobenzamide mustard prodrugs in preclinical models
DC Singleton
PhD Thesis-University of Auckland, 2009
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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