| Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses R Khayat, L Tang, ET Larson, CM Lawrence, M Young, JE Johnson Proceedings of the National Academy of Sciences 102 (52), 18944-18949, 2005 | 218 | 2005 |
| Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors KK Ojo, ET Larson, KR Keyloun, LJ Castaneda, AE DeRocher, ... Nature structural & molecular biology 17 (5), 602-607, 2010 | 190 | 2010 |
| Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii RC Murphy, KK Ojo, ET Larson, A Castellanos-Gonzalez, BGK Perera, ... ACS medicinal chemistry letters 1 (7), 331-335, 2010 | 143* | 2010 |
| Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity SM Johnson, RC Murphy, JA Geiger, AE DeRocher, Z Zhang, KK Ojo, ... Journal of medicinal chemistry 55 (5), 2416-2426, 2012 | 118 | 2012 |
| Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors KK Ojo, C Pfander, NR Mueller, C Burstroem, ET Larson, CM Bryan, ... The Journal of clinical investigation 122 (6), 2301-2305, 2012 | 113 | 2012 |
| Structural basis for type VI secretion effector recognition by a cognate immunity protein M Li, I Le Trong, MA Carl, ET Larson, S Chou, JA De Leon, SL Dove, ... PLoS pathogens 8 (4), e1002613, 2012 | 83 | 2012 |
| Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl ET Larson, F Parussini, MH Huynh, JD Giebel, AM Kelley, L Zhang, ... Journal of Biological Chemistry 284 (39), 26839-26850, 2009 | 74 | 2009 |
| Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1 ET Larson, KK Ojo, RC Murphy, SM Johnson, Z Zhang, JE Kim, DJ Leibly, ... Journal of medicinal chemistry 55 (6), 2803-2810, 2012 | 72 | 2012 |
| Active site profiling reveals coupling between domains in SRC-family kinases R Krishnamurty, JL Brigham, SE Leonard, P Ranjitkar, ET Larson, EJ Dale, ... Nature chemical biology 9 (1), 43-50, 2013 | 66 | 2013 |
| A winged-helix protein from Sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus ET Larson, B Eilers, S Menon, D Reiter, A Ortmann, MJ Young, ... Virology 368 (2), 249-261, 2007 | 64 | 2007 |
| Affinity-based probes based on type II kinase inhibitors P Ranjitkar, BGK Perera, DL Swaney, SB Hari, ET Larson, R Krishnamurty, ... Journal of the American Chemical Society 134 (46), 19017-19025, 2012 | 62 | 2012 |
| A new DNA binding protein highly conserved in diverse crenarchaeal viruses ET Larson, BJ Eilers, D Reiter, AC Ortmann, MJ Young, CM Lawrence Virology 363 (2), 387-396, 2007 | 62 | 2007 |
| Structure of A197 from Sulfolobus Turreted Icosahedral Virus: a Crenarchaeal Viral Glycosyltransferase Exhibiting the GT-A Fold ET Larson, D Reiter, M Young, CM Lawrence Journal of Virology 80 (15), 7636-7644, 2006 | 60 | 2006 |
| Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate ET Larson, JE Kim, FH Zucker, A Kelley, N Mueller, AJ Napuli, ... Biochimie 93 (3), 570-582, 2011 | 52 | 2011 |
| Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1 Z Zhang, KK Ojo, SM Johnson, ET Larson, P He, JA Geiger, ... Bioorganic & medicinal chemistry letters 22 (16), 5264-5267, 2012 | 49 | 2012 |
| Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium CLMJ Verlinde, E Fan, S Shibata, Z Zhang, Z Sun, W Deng, J Ross, J Kim, ... Current topics in medicinal chemistry 9 (18), 1678-1687, 2009 | 44 | 2009 |
| The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer ET Larson, JE Kim, LJ Castaneda, AJ Napuli, Z Zhang, E Fan, FH Zucker, ... Journal of molecular biology 409 (2), 159-176, 2011 | 41 | 2011 |
| Structures of substrate-and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity ET Larson, W Deng, BE Krumm, A Napuli, N Mueller, WC Van Voorhis, ... Journal of molecular biology 381 (4), 975-988, 2008 | 39 | 2008 |
| Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs EA Merritt, TL Arakaki, JR Gillespie, ET Larson, A Kelley, N Mueller, ... Journal of molecular biology 397 (2), 481-494, 2010 | 38 | 2010 |
| Prediction of protein crystallization outcome using a hybrid method FH Zucker, C Stewart, J dela Rosa, J Kim, L Zhang, L Xiao, J Ross, ... Journal of structural biology 171 (1), 64-73, 2010 | 26 | 2010 |
