| Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved? M Boiani, L Piacenza, P Hernandez, L Boiani, H Cerecetto, M Gonzalez, ... Biochemical pharmacology 79 (12), 1736-1745, 2010 | 172 | 2010 |
| Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates NC Romeiro, G Aguirre, P Hernández, M González, H Cerecetto, I Aldana, ... Bioorganic & medicinal chemistry 17 (2), 641-652, 2009 | 149 | 2009 |
| Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives P Hernández, M Cabrera, ML Lavaggi, L Celano, I Tiscornia, TR da Costa, ... Bioorganic & medicinal chemistry 20 (6), 2158-2171, 2012 | 92 | 2012 |
| Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates P Hernández, R Rojas, RH Gilman, M Sauvain, LM Lima, EJ Barreiro, ... European Journal of Medicinal Chemistry 59, 64-74, 2013 | 89 | 2013 |
| 3-Trifluoromethylquinoxaline N,N′-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Agents and Mechanism of Action Studies D Benitez, M Cabrera, P Hernández, L Boiani, ML Lavaggi, R Di Maio, ... Journal of medicinal chemistry 54 (10), 3624-3636, 2011 | 84 | 2011 |
| New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle W Porcal, P Hernández, L Boiani, M Boiani, A Ferreira, A Chidichimo, ... Bioorganic & medicinal chemistry 16 (14), 6995-7004, 2008 | 80 | 2008 |
| Heteroarylnitrones as drugs for neurodegenerative diseases: synthesis, neuroprotective properties, and free radical scavenger properties W Porcal, P Hernández, M González, A Ferreira, C Olea-Azar, ... Journal of medicinal chemistry 51 (19), 6150-6159, 2008 | 76 | 2008 |
| 4-Nitroacetophenone-derived thiosemicarbazones and their copper (II) complexes with significant in vitro anti-trypanosomal activity A Pérez-Rebolledo, LR Teixeira, AA Batista, AS Mangrich, G Aguirre, ... European journal of medicinal chemistry 43 (5), 939-948, 2008 | 75 | 2008 |
| Changes in the survival of patients with systemic lupus erythematosus in childhood: 30 years experience in Chile B González, P Hernandez, H Olguin, M Miranda, L Lira, M Toso, ... Lupus 14 (11), 918-923, 2005 | 73 | 2005 |
| 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene A Gerpe, G Álvarez, D Benítez, L Boiani, M Quiroga, P Hernández, ... Bioorganic & medicinal chemistry 17 (21), 7500-7509, 2009 | 70 | 2009 |
| Second generation of 2H-benzimidazole 1, 3-dioxide derivatives as anti-trypanosomatid agents: Synthesis, biological evaluation, and mode of action studies M Boiani, L Boiani, A Merlino, P Hernandez, A Chidichimo, JJ Cazzulo, ... European journal of medicinal chemistry 44 (11), 4426-4433, 2009 | 57 | 2009 |
| Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure–activity relationships W Porcal, P Hernández, G Aguirre, L Boiani, M Boiani, A Merlino, ... Bioorganic & medicinal chemistry 15 (7), 2768-2781, 2007 | 57 | 2007 |
| Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies D Castro, L Boiani, D Benitez, P Hernandez, A Merlino, C Gil, C Olea-Azar, ... European journal of medicinal chemistry 44 (12), 5055-5065, 2009 | 53 | 2009 |
| Naftifine-analogues as anti-Trypanosoma cruzi agents A Gerpe, L Boiani, P Hernández, M Sortino, S Zacchino, M Gonzalez, ... European journal of medicinal chemistry 45 (6), 2154-2164, 2010 | 49 | 2010 |
| Development of second generation amidinohydrazones, thio-and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1, 3-dioxide core scaffolds A Merlino, D Benitez, S Chavez, J Da Cunha, P Hernández, LW Tinoco, ... Medchemcomm 1 (3), 216-228, 2010 | 49 | 2010 |
| Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites F Ross, P Hernández, W Porcal, GV López, H Cerecetto, M González, ... PLoS One 7 (4), e35033, 2012 | 45 | 2012 |
| Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction M Cabrera, ML Lavaggi, P Hernández, A Merlino, A Gerpe, W Porcal, ... Toxicology letters 190 (2), 140-149, 2009 | 44 | 2009 |
| In Vivo Anti-Chagas Vinylthio-, Vinylsulfinyl-, and Vinylsulfonylbenzofuroxan Derivatives W Porcal, P Hernández, M Boiani, G Aguirre, L Boiani, A Chidichimo, ... Journal of medicinal chemistry 50 (24), 6004-6015, 2007 | 40 | 2007 |
| Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization GV Lopez, F Blanco, P Hernández, A Ferreira, OE Piro, C Batthyány, ... Bioorganic & medicinal chemistry 15 (18), 6262-6272, 2007 | 40 | 2007 |
| A natural occurring bifunctional CPD/(6-4)-photolyase from the Antarctic bacterium Sphingomonas sp. UV9 JJ Marizcurrena, S Acosta, L Canclini, P Hernández, D Vallés, ... Applied Microbiology and Biotechnology 104, 7037-7050, 2020 | 20 | 2020 |
Williams PorcalProf. Agr. Departamento de Química Orgánica, Facultad de Química, Universidad de la RepúblicaVerified email at fq.edu.uy
