Mark J O'Connor
Cited by
Cited by
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
PC Fong, DS Boss, TA Yap, A Tutt, P Wu, M Mergui-Roelvink, P Mortimer, ...
New England Journal of Medicine 361 (2), 123-134, 2009
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition
N McCabe, NC Turner, CJ Lord, K Kluzek, A Białkowska, S Swift, ...
Cancer research 66 (16), 8109-8115, 2006
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
S Rottenberg, JE Jaspers, A Kersbergen, E van der Burg, AOH Nygren, ...
Proceedings of the National Academy of Sciences 105 (44), 17079-17084, 2008
Targeting the DNA damage response in cancer
MJ O’Connor
Molecular cell 60 (4), 547-560, 2015
4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1
KA Menear, C Adcock, R Boulter, X Cockcroft, L Copsey, A Cranston, ...
Journal of medicinal chemistry 51 (20), 6581-6591, 2008
The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300
H Zimmermann, R Degenkolbe, HU Bernard, MJ O’Connor
Journal of virology 73 (8), 6209-6219, 1999
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors
JE Jaspers, A Kersbergen, U Boon, W Sol, L Van Deemter, SA Zander, ...
Cancer discovery 3 (1), 68-81, 2013
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage
A Moumen, P Masterson, MJ O'Connor, SP Jackson
Cell 123 (6), 1065-1078, 2005
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
B Evers, R Drost, E Schut, M de Bruin, E van der Burg, PWB Derksen, ...
Clinical Cancer Research 14 (12), 3916-3925, 2008
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
SE Golding, E Rosenberg, N Valerie, I Hussaini, M Frigerio, XF Cockcroft, ...
Molecular cancer therapeutics 8 (10), 2894-2902, 2009
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
PM Krawczyk, B Eppink, J Essers, J Stap, H Rodermond, H Odijk, ...
Proceedings of the National Academy of Sciences 108 (24), 9851-9856, 2011
The overexpression of specialized DNA polymerases in cancer
MR Albertella, A Lau, MJ O’Connor
DNA repair 4 (5), 583-593, 2005
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
Y Pommier, MJ O’Connor, J De Bono
Science translational medicine 8 (362), 362ps17-362ps17, 2016
A role for polymerase η in the cellular tolerance to cisplatin-induced damage
MR Albertella, CM Green, AR Lehmann, MJ O'Connor
Cancer research 65 (21), 9799-9806, 2005
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
A Lau, KM Swinbank, PS Ahmed, DL Taylor, SP Jackson, GCM Smith, ...
Nature cell biology 7 (5), 493-500, 2005
ATM deficiency sensitizes mantle cell lymphoma cells to poly (ADP-ribose) polymerase-1 inhibitors
CT Williamson, H Muzik, AG Turhan, A Zam˛, MJ O'Connor, DG Bebb, ...
Molecular cancer therapeutics 9 (2), 347-357, 2010
Randomized, double-blind phase II trial with prospective classification by ATM protein level to evaluate the efficacy and tolerability of olaparib plus paclitaxel in patientsá…
YJ Bang, SA Im, KW Lee, JY Cho, EK Song, KH Lee, YH Kim, JO Park, ...
Journal of clinical oncology 33 (33), 3858-3865, 2015
Targeted cancer therapies based on the inhibition of DNA strand break repair
MJ O'connor, NMB Martin, GCM Smith
Oncogene 26 (56), 7816-7824, 2007
Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft
JM Senra, BA Telfer, KE Cherry, CM McCrudden, DG Hirst, MJ O'Connor, ...
Molecular cancer therapeutics 10 (10), 1949-1958, 2011
ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation
L Biddlestone-Thorpe, M Sajjad, E Rosenberg, JM Beckta, NCK Valerie, ...
Clinical Cancer Research 19 (12), 3189-3200, 2013
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