Sandeep Somani
Sandeep Somani
Janssen R&D
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Modeling and simulation of biological systems with stochasticity
TC Meng, S Somani, P Dhar
In silico biology 4 (3), 293-309, 2004
Configurational Entropy in Protein–Peptide Binding:: Computational Study of Tsg101 Ubiquitin E2 Variant Domain with an HIV-Derived PTAP Nonapeptide
BJ Killian, JY Kravitz, S Somani, P Dasgupta, YP Pang, MK Gilson
Journal of molecular biology 389 (2), 315-335, 2009
Cellware—a multi-algorithmic software for computational systems biology
P Dhar, TC Meng, S Somani, L Ye, A Sairam, M Chitre, Z Hao, ...
Bioinformatics 20 (8), 1319-1321, 2004
Grid cellware: the first grid-enabled tool for modelling and simulating cellular processes
PK Dhar, TC Meng, S Somani, L Ye, K Sakharkar, A Krishnan, ...
Bioinformatics 21 (7), 1284-1287, 2005
Exploiting the potential energy landscape to sample free energy
AJ Ballard, S Martiniani, JD Stevenson, S Somani, DJ Wales
Wiley Interdisciplinary Reviews: Computational Molecular Science 5 (3), 273-289, 2015
Hydration of a hydrophobic cavity and its functional role: a simulation study of human interleukin‐1β
S Somani, CP Chng, CS Verma
Proteins: Structure, Function, and Bioinformatics 67 (4), 868-885, 2007
Efficient generation of bispecific murine antibodies for pre-clinical investigations in syngeneic rodent models
AF Labrijn, JI Meesters, M Bunce, AA Armstrong, S Somani, TC Nesspor, ...
Scientific reports 7 (1), 1-14, 2017
Energy landscapes and global thermodynamics for alanine peptides
S Somani, DJ Wales
The Journal of chemical physics 139 (12), 09B609_1, 2013
Homology‐based hydrogen bond information improves crystallographic structures in the PDB
B van Beusekom, WG Touw, M Tatineni, S Somani, G Rajagopal, J Luo, ...
Protein Science 27 (3), 798-808, 2018
Functional, biophysical, and structural characterization of human IgG1 and IgG4 Fc variants with ablated immune functionality
SH Tam, SG McCarthy, AA Armstrong, S Somani, SJ Wu, X Liu, A Gervais, ...
Antibodies 6 (3), 12, 2017
A conformational factorisation approach for estimating the binding free energies of macromolecules
K Mochizuki, CS Whittleston, S Somani, H Kusumaatmaja, DJ Wales
Physical Chemistry Chemical Physics 16 (7), 2842-2853, 2014
Sampling conformations in high dimensions using low-dimensional distribution functions
S Somani, BJ Killian, MK Gilson
The Journal of chemical physics 130 (13), 04B603, 2009
Accelerated convergence of molecular free energy via superposition approximation-based reference states
S Somani, MK Gilson
The Journal of chemical physics 134 (13), 04B604, 2011
Cellware: the grid-enabled tool for cell modeling and simulation
TC Meng, S Somani, L Ye, A Sairam, Z Hao, A Krishnan, K Sakharkar, ...
Bioinformatics 20, 1319-1321, 2004
Conformational sampling and calculation of molecular free energy using superposition approximations
S Somani
Modeling and simulation in systems biology: the genesis and evolution of challenges, strategies and methods
PK Dhar, H Zhu, CM Tan, S Somani, Y Li, SK Mishra
Bioinformaties Institute of Singapore (invited paper by IEEE), 2005
Toward biotherapeutics formulation composition Engineering using site-identification by ligand competitive saturation (SILCS)
S Somani, S Jo, R Thirumangalathu, D Rodrigues, LM Tanenbaum, ...
Journal of Pharmaceutical Sciences 110 (3), 1103-1110, 2021
Computational Characterization of Antibody–Excipient Interactions for Rational Excipient Selection Using the Site Identification by Ligand Competitive Saturation-Biologics Approach
S Jo, A Xu, JE Curtis, S Somani, AD MacKerell Jr
Molecular Pharmaceutics 17 (11), 4323-4333, 2020
Equilibrium Molecular Thermodynamics from Kirkwood Sampling
S Somani, Y Okamoto, AJ Ballard, DJ Wales
The Journal of Physical Chemistry B 119 (20), 6155-6169, 2015
Product-Specific Impact of Viscosity Modulating Formulation Excipients During Ultra-High Concentration Biotherapeutics Drug Product Development
D Rodrigues, LM Tanenbaum, R Thirumangalathu, S Somani, K Zhang, ...
Journal of Pharmaceutical Sciences 110 (3), 1077-1082, 2021
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