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Alessio Lodola
Alessio Lodola
Associate Professor of Medicinal Chemistry, University of Parma
Email verificata su unipr.it - Home page
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Anno
Cyclohexylcarbamic acid 3 ‘-or 4 ‘-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure− activity relationships, and …
M Mor, S Rivara, A Lodola, PV Plazzi, G Tarzia, A Duranti, A Tontini, ...
Journal of medicinal chemistry 47 (21), 4998-5008, 2004
3282004
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
C Solorzano, C Zhu, N Battista, G Astarita, A Lodola, S Rivara, M Mor, ...
Proceedings of the National Academy of Sciences 106 (49), 20966-20971, 2009
2592009
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
C Solorzano, C Zhu, N Battista, G Astarita, A Lodola, S Rivara, M Mor, ...
Proceedings of the National Academy of Sciences 106 (49), 20966-20971, 2009
2592009
A catalytically silent FAAH-1 variant drives anandamide transport in neurons
J Fu, G Bottegoni, O Sasso, R Bertorelli, W Rocchia, M Masetti, A Guijarro, ...
Nature neuroscience 15 (1), 64-69, 2012
2192012
5-Benzylidene-hydantoins as new EGFR inhibitors with antiproliferative activity
C Carmi, A Cavazzoni, V Zuliani, A Lodola, F Bordi, PV Plazzi, RR Alfieri, ...
Bioorganic & medicinal chemistry letters 16 (15), 4021-4025, 2006
1272006
Discovery of potent and reversible monoacylglycerol lipase inhibitors
AR King, EY Dotsey, A Lodola, KM Jung, A Ghomian, Y Qiu, J Fu, M Mor, ...
Chemistry & biology 16 (10), 1045-1052, 2009
1202009
N-(Substituted-anilinoethyl)amides: Design, Synthesis, and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands
S Rivara, A Lodola, M Mor, A Bedini, G Spadoni, V Lucini, M Pannacci, ...
Journal of medicinal chemistry 50 (26), 6618-6626, 2007
982007
Mechanism of inhibition of SARS-CoV-2 M pro by N3 peptidyl Michael acceptor explained by QM/MM simulations and design of new derivatives with tunable chemical reactivity
K Arafet, N Serrano-Aparicio, A Lodola, AJ Mulholland, FV González, ...
Chemical Science 12 (4), 1433-1444, 2021
972021
Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study
A Berteotti, F Vacondio, A Lodola, M Bassi, C Silva, M Mor, A Cavalli
ACS medicinal chemistry letters 5 (5), 501-505, 2014
952014
A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone‐based enzyme inhibitors
AR King, A Lodola, C Carmi, J Fu, M Mor, D Piomelli
British journal of pharmacology 157 (6), 974-983, 2009
952009
Targeting Eph/ephrin system in cancer therapy
A Lodola, C Giorgio, M Incerti, I Zanotti, M Tognolini
European journal of medicinal chemistry 142, 152-162, 2017
882017
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation
C Giorgio, I Hassan Mohamed, L Flammini, E Barocelli, M Incerti, ...
PloS one 6 (3), e18128, 2011
882011
Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase
A Lodola, M Mor, J Zurek, G Tarzia, D Piomelli, JN Harvey, AJ Mulholland
Biophysical journal 92 (2), L20-L22, 2007
852007
Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines
A Cavazzoni, RR Alfieri, C Carmi, V Zuliani, M Galetti, C Fumarola, ...
Molecular cancer therapeutics 7 (2), 361-370, 2008
812008
Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides
C Carmi, E Galvani, F Vacondio, S Rivara, A Lodola, S Russo, S Aiello, ...
Journal of medicinal chemistry 55 (5), 2251-2264, 2012
772012
Synthesis and quantitative structure− activity relationship of fatty acid amide hydrolase inhibitors: Modulation at the N-portion of biphenyl-3-yl alkylcarbamates
M Mor, A Lodola, S Rivara, F Vacondio, A Duranti, A Tontini, S Sanchini, ...
Journal of medicinal chemistry 51 (12), 3487-3498, 2008
762008
L718Q mutant EGFR escapes covalent inhibition by stabilizing a non-reactive conformation of the lung cancer drug osimertinib
D Callegari, KE Ranaghan, CJ Woods, R Minari, M Tiseo, M Mor, ...
Chemical Science 9 (10), 2740-2749, 2018
752018
Synthesis and Structure−Activity Relationships of N-(2-Oxo-3-oxetanyl)amides as N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors
C Solorzano, F Antonietti, A Duranti, A Tontini, S Rivara, A Lodola, ...
Journal of medicinal chemistry 53 (15), 5770-5781, 2010
752010
Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion
C Carmi, A Cavazzoni, S Vezzosi, F Bordi, F Vacondio, C Silva, S Rivara, ...
Journal of medicinal chemistry 53 (5), 2038-2050, 2010
752010
Synthesis and structure–activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring
G Tarzia, A Duranti, G Gatti, G Piersanti, A Tontini, S Rivara, A Lodola, ...
ChemMedChem: Chemistry Enabling Drug Discovery 1 (1), 130-139, 2006
732006
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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