| Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer SA Eccles, EO Aboagye, S Ali, AS Anderson, J Armes, F Berditchevski, ... Breast Cancer Research 15, 1-37, 2013 | 503 | 2013 |
| Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage K Webley, JA Bond, CJ Jones, JP Blaydes, A Craig, T Hupp, ... Molecular and cellular biology 20 (8), 2803-2808, 2000 | 256 | 2000 |
| Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. J Bond, M Haughton, J Blaydes, V Gire, D Wynford-Thomas, F Wyllie Oncogene 13 (10), 2097-2104, 1996 | 220 | 1996 |
| Cancer‐associated fibroblasts predict poor outcome and promote periostin‐dependent invasion in oesophageal adenocarcinoma TJ Underwood, AL Hayden, M Derouet, E Garcia, F Noble, MJ White, ... The Journal of pathology 235 (3), 466-477, 2015 | 200 | 2015 |
| Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines G Babbage, CH Ottensmeier, J Blaydes, FK Stevenson, SS Sahota Cancer research 66 (8), 3996-4000, 2006 | 162 | 2006 |
| p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor α-positive … M Phelps, M Darley, JN Primrose, JP Blaydes Cancer research 63 (10), 2616-2623, 2003 | 130 | 2003 |
| Stoichiometric Phosphorylation of Human p53 at Ser315Stimulates p53-dependent Transcription JP Blaydes, MG Luciani, S Pospisilova, HML Ball, B Vojtesek, TR Hupp Journal of Biological Chemistry 276 (7), 4699-4708, 2001 | 121 | 2001 |
| DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site JP Blaydes, TR Hupp Oncogene 17 (8), 1045-1052, 1998 | 121 | 1998 |
| Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1 JA Bond, JP Blaydes, J Rowson, MF Haughton, JR Smith, ... Cancer research 55 (11), 2404-2409, 1995 | 121 | 1995 |
| Targeting tumour proliferation with a small‐molecule inhibitor of AICAR transformylase homodimerization IB Spurr, CN Birts, F Cuda, SJ Benkovic, JP Blaydes, A Tavassoli Chembiochem 13 (11), 1628-1634, 2012 | 111 | 2012 |
| The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival MJ Wheater, PWM Johnson, JP Blaydes Cancer biology & therapy 10 (7), 728-735, 2010 | 111 | 2010 |
| Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2 JP Blaydes, V Gire, JM Rowson, D Wynford-Thomas Oncogene 14 (15), 1859-1868, 1997 | 103 | 1997 |
| Transcription of click‐linked DNA in human cells CN Birts, AP Sanzone, AH El‐Sagheer, JP Blaydes, T Brown, A Tavassoli Angewandte Chemie International Edition 53 (9), 2362-2365, 2014 | 96 | 2014 |
| Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription AH Mirnezami, SJ Campbell, M Darley, JN Primrose, PWM Johnson, ... Current biology 13 (14), 1234-1239, 2003 | 95 | 2003 |
| A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells CN Birts, SK Nijjar, CA Mardle, F Hoakwie, PJ Duriez, JP Blaydes, ... Chemical Science 4 (8), 3046-3057, 2013 | 90 | 2013 |
| The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2 JP Blaydes, D Wynford-Thomas Oncogene 16 (25), 3317-3322, 1998 | 83 | 1998 |
| HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity*[S] A Phillips, A Teunisse, S Lam, K Lodder, M Darley, M Emaduddin, A Wolf, ... Journal of biological chemistry 285 (38), 29111-29127, 2010 | 79 | 2010 |
| Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways JP Blaydes, AL Craig, M Wallace, H Ball, NJ Traynor, NK Gibbs, TR Hupp Oncogene 19 (34), 3829-3839, 2000 | 77 | 2000 |
| C-terminal binding proteins: emerging roles in cell survival and tumorigenesis LM Bergman, JP Blaydes Apoptosis 11, 879-888, 2006 | 74 | 2006 |
| MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm M Phelps, A Phillips, M Darley, JP Blaydes Journal of Biological Chemistry 280 (17), 16651-16658, 2005 | 74 | 2005 |
