Protein farnesyltransferase inhibitors exhibit potent antimalarial activity L Nallan, KD Bauer, P Bendale, K Rivas, K Yokoyama, CP Hornéy, ... Journal of medicinal chemistry 48 (11), 3704-3713, 2005 | 226 | 2005 |
A noncoding RNA antisense to moesin at 5p14. 1 in autism T Kerin, A Ramanathan, K Rivas, N Grepo, GA Coetzee, DB Campbell Science translational medicine 4 (128), 128ra40-128ra40, 2012 | 151 | 2012 |
Novel paradigms for drug discovery: computational multitarget screening E Jenwitheesuk, JA Horst, KL Rivas, WC Van Voorhis, R Samudrala Trends in pharmacological sciences 29 (2), 62-71, 2008 | 148 | 2008 |
A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation KK Ojo, RT Eastman, RSR Vidadala, Z Zhang, KL Rivas, R Choi, JD Lutz, ... The Journal of infectious diseases 209 (2), 275-284, 2014 | 101 | 2014 |
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with … RSR Vidadala, KL Rivas, KK Ojo, MA Hulverson, JA Zambriski, I Bruzual, ... Journal of medicinal chemistry 59 (13), 6531-6546, 2016 | 90 | 2016 |
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials P Bendale, S Olepu, PK Suryadevara, V Bulbule, K Rivas, L Nallan, ... Journal of medicinal chemistry 50 (19), 4585-4605, 2007 | 90 | 2007 |
A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis A Castellanos-Gonzalez, AC White Jr, KK Ojo, RSR Vidadala, Z Zhang, ... The Journal of infectious diseases 208 (8), 1342-1348, 2013 | 81 | 2013 |
Novel bumped kinase inhibitors are safe and effective therapeutics in the calf clinical model for cryptosporidiosis DA Schaefer, DP Betzer, KD Smith, ZG Millman, HC Michalski, ... The Journal of infectious diseases 214 (12), 1856-1864, 2016 | 69 | 2016 |
2-Oxo-tetrahydro-1, 8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials S Olepu, PK Suryadevara, K Rivas, K Yokoyama, CLMJ Verlinde, ... Bioorganic & medicinal chemistry letters 18 (2), 494-497, 2008 | 69 | 2008 |
Bumped-kinase inhibitors for cryptosporidiosis therapy MA Hulverson, S Vinayak, R Choi, DA Schaefer, A Castellanos-Gonzalez, ... The Journal of infectious diseases 215 (8), 1275-1284, 2017 | 61 | 2017 |
Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold Z Zhang, KK Ojo, RSR Vidadala, W Huang, JA Geiger, S Scheele, R Choi, ... ACS medicinal chemistry letters 5 (1), 40-44, 2014 | 60 | 2014 |
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase MA Hast, S Fletcher, CG Cummings, EE Pusateri, MA Blaskovich, K Rivas, ... Chemistry & biology 16 (2), 181-192, 2009 | 58 | 2009 |
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase SN Hewitt, DM Dranow, BG Horst, JA Abendroth, B Forte, I Hallyburton, ... ACS infectious diseases 3 (1), 34-44, 2017 | 57 | 2017 |
Structurally Simple, Potent, Plasmodium Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites MP Glenn, SY Chang, C Hornéy, K Rivas, K Yokoyama, EE Pusateri, ... Journal of medicinal chemistry 49 (19), 5710-5727, 2006 | 53 | 2006 |
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites MP Glenn, SY Chang, O Hucke, CLMJ Verlinde, K Rivas, C Hornéy, ... Angewandte Chemie International Edition 44 (31), 4903-4906, 2005 | 53 | 2005 |
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure− activity relationships of ethylenediamine-analogue scaffolds … S Fletcher, CG Cummings, K Rivas, WP Katt, C Hornéy, FS Buckner, ... Journal of medicinal chemistry 51 (17), 5176-5197, 2008 | 49 | 2008 |
Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase WC Van Voorhis, KL Rivas, P Bendale, L Nallan, C Hornéy, LK Barrett, ... Antimicrobial agents and chemotherapy 51 (10), 3659-3671, 2007 | 48 | 2007 |
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds GJ Crowther, HK Hillesland, KR Keyloun, MC Reid, ... PloS one 11 (3), e0149996, 2016 | 47 | 2016 |
2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability VJ Bulbule, K Rivas, CLMJ Verlinde, WC Van Voorhis, MH Gelb Journal of medicinal chemistry 51 (3), 384-387, 2008 | 44 | 2008 |
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1 W Huang, KK Ojo, Z Zhang, K Rivas, RSR Vidadala, S Scheele, ... ACS medicinal chemistry letters 6 (12), 1184-1189, 2015 | 37 | 2015 |