| Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease A Abbate, S Toldo, C Marchetti, J Kron, BW Van Tassell, CA Dinarello Circulation research 126 (9), 1260-1280, 2020 | 458 | 2020 |
| OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation C Marchetti, B Swartzwelter, F Gamboni, CP Neff, K Richter, T Azam, ... Proceedings of the National Academy of Sciences 115 (7), E1530-E1539, 2018 | 381 | 2018 |
| A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia–reperfusion in the mouse C Marchetti, J Chojnacki, S Toldo, E Mezzaroma, N Tranchida, SW Rose, ... Journal of cardiovascular pharmacology 63 (4), 316-322, 2014 | 262 | 2014 |
| Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse S Toldo, C Marchetti, AG Mauro, J Chojnacki, E Mezzaroma, S Carbone, ... International Journal of Cardiology 209, 215-220, 2016 | 199 | 2016 |
| Myocardial infarction induces embryonic reprogramming of epicardial c-kit+ cells: Role of the pericardial fluid F Limana, C Bertolami, A Mangoni, A Di Carlo, D Avitabile, D Mocini, ... Journal of molecular and cellular cardiology 48 (4), 609-618, 2010 | 173 | 2010 |
| The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease N Lonnemann, S Hosseini, C Marchetti, DB Skouras, D Stefanoni, ... Proceedings of the National Academy of Sciences 117 (50), 32145-32154, 2020 | 171 | 2020 |
| Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and nonischemic injury in the mouse C Marchetti, S Toldo, J Chojnacki, E Mezzaroma, K Liu, FN Salloum, ... Journal of cardiovascular pharmacology 66 (1), 1-8, 2015 | 158 | 2015 |
| Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure LC O’Brien, E Mezzaroma, BW Van Tassell, C Marchetti, S Carbone, ... Molecular Medicine 20 (1), 221-229, 2014 | 158 | 2014 |
| Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial V Klück, L Tim, M Janssen, A Comarniceanu, M Efdé, IW Tengesdal, ... The Lancet Rheumatology 2 (5), e270-e280, 2020 | 150 | 2020 |
| Interleukin-18 mediates interleukin-1-induced cardiac dysfunction S Toldo, E Mezzaroma, L O'Brien, C Marchetti, IM Seropian, NF Voelkel, ... American Journal of Physiology-Heart and Circulatory Physiology 306 (7 …, 2014 | 142 | 2014 |
| NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis C Marchetti, B Swartzwelter, MI Koenders, T Azam, IW Tengesdal, ... Arthritis research & therapy 20, 1-11, 2018 | 134 | 2018 |
| Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice S Toldo, A Das, E Mezzaroma, VQ Chau, C Marchetti, D Durrant, ... Circulation: Cardiovascular Genetics 7 (3), 311-320, 2014 | 125 | 2014 |
| Interleukin‐1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse S Toldo, E Mezzaroma, BW Van Tassell, D Farkas, C Marchetti, ... Experimental physiology 98 (3), 734-745, 2013 | 113 | 2013 |
| Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion IW Tengesdal, DR Menon, DG Osborne, CP Neff, NE Powers, F Gamboni, ... Proceedings of the National Academy of Sciences 118 (10), e2000915118, 2021 | 108 | 2021 |
| Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS … J Valle Raleigh, AG Mauro, T Devarakonda, C Marchetti, J He, E Kim, ... Cardiovascular research 113 (6), 609-619, 2017 | 101 | 2017 |
| A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice S Carbone, AG Mauro, E Mezzaroma, D Kraskauskas, C Marchetti, ... International journal of cardiology 198, 66-69, 2015 | 84 | 2015 |
| Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart S Toldo, E Mezzaroma, MD McGeough, CA Pena, C Marchetti, C Sonnino, ... Cardiovascular research 105 (2), 203-212, 2015 | 83 | 2015 |
| Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse S Toldo, E Mezzaroma, E Bressi, C Marchetti, S Carbone, C Sonnino, ... Journal of cardiovascular pharmacology 64 (1), 1-6, 2014 | 80 | 2014 |
| A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II JA Regan, AG Mauro, S Carbone, C Marchetti, R Gill, E Mezzaroma, ... American Journal of Physiology-Heart and Circulatory Physiology 309 (5 …, 2015 | 76 | 2015 |
| Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo S Li, G Fossati, C Marchetti, D Modena, P Pozzi, LL Reznikov, ML Moras, ... Journal of Biological Chemistry 290 (4), 2368-2378, 2015 | 67 | 2015 |
Stefano ToldoUniversity of VirginiaVerified email at virginia.edu
