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agostino bruno
agostino bruno
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Year
Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief
A Moriconi, TM Cunha, GR Souza, AH Lopes, FQ Cunha, VL Carneiro, ...
Proceedings of the National Academy of Sciences 111 (47), 16937-16942, 2014
772014
Molecular Dynamics Simulation of the Heterodimeric mGluR2/5HT2A Complex. An Atomistic Resolution Study of a Potential New Target in Psychiatric Conditions
A Bruno, AE Guadix, G Costantino
Journal of chemical information and modeling 49 (6), 1602-1616, 2009
622009
Discovery of New Potential Anti‐Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target‐Focused Repurposing Approaches
G Annunziato, A Angeli, F D'Alba, A Bruno, M Pieroni, D Vullo, V De Luca, ...
ChemMedChem 11 (17), 1904-1914, 2016
542016
The in silico drug discovery toolbox: applications in lead discovery and optimization
A Bruno, G Costantino, L Sartori, M Radi
Current Medicinal Chemistry 26 (21), 3838-3873, 2019
522019
Identification of Breast Cancer Inhibitors Specific for G Protein‐Coupled Estrogen Receptor (GPER)‐Expressing Cells
F Aiello, G Carullo, F Giordano, E Spina, A Nigro, A Garofalo, S Tassini, ...
ChemMedChem 12 (16), 1279-1285, 2017
502017
Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
http://pubs.acs.org/doi/abs/10.1021/jm5011622 57 (23), 9945–9957, 2014
49*2014
Accepting the invitation to open innovation in malaria drug discovery: synthesis, biological evaluation, and investigation on the structure–activity relationships of benzo [b …
M Pieroni, E Azzali, N Basilico, S Parapini, M Zolkiewski, C Beato, ...
Journal of medicinal chemistry 60 (5), 1959-1970, 2017
482017
Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS
A Colanzi, G Grimaldi, G Catara, C Valente, C Cericola, P Liberali, ...
Proceedings of the National Academy of Sciences 110 (24), 9794-9799, 2013
472013
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments
M Stornaiuolo, A Bruno, L Botta, GL Regina, S Cosconati, R Silvestri, ...
Scientific reports 5 (1), 15453, 2015
462015
Structure–activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human …
S Castellano, S Taliani, M Viviano, C Milite, E Da Pozzo, B Costa, ...
Journal of Medicinal Chemistry 57 (6), 2413-2428, 2014
462014
Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR
A Bruno, G Costantino, G De Fabritiis, M Pastor, J Selent
Public Library of Science 7 (8), e42023, 2012
462012
Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase
L Amori, S Katkevica, A Bruno, B Campanini, P Felici, A Mozzarelli, ...
MedChemComm 3 (9), 1111-1116, 2012
452012
Pharmacological folding chaperones act as allosteric ligands of Frizzled4
SF Generoso, M Giustiniano, G La Regina, S Bottone, S Passacantilli, ...
Nature Chemical Biology 11 (4), 280-286, 2015
432015
Beyond radio-displacement techniques for Identification of CB1 Ligands: The First Application of a Fluorescence-quenching Assay
A Bruno, F Lembo, E Novellino, M Stornaiuolo, L Marinelli
Scientific Reports 4 (1), 3757, 2014
332014
Unbinding pathways from the glucocorticoid receptor shed light on the reduced sensitivity of glucocorticoid ligands to a naturally occurring, clinically relevant mutant receptor
AM Capelli, A Bruno, A Entrena Guadix, G Costantino
Journal of medicinal chemistry 56 (17), 7003-7014, 2013
332013
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides
E Barresi, A Bruno, S Taliani, S Cosconati, E Da Pozzo, S Salerno, ...
Journal of Medicinal Chemistry 58 (15), 6081-6092, 2015
312015
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands
S Bertini, T Parkkari, JR Savinainen, C Arena, G Saccomanni, S Saguto, ...
European Journal of Medicinal Chemistry 90, 526-536, 2015
272015
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer …
G Annunziato, M Pieroni, R Benoni, B Campanini, TA Pertinhez, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 31 (sup4), 78-87, 2016
252016
The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions
M Biagioli, A Carino, C Fiorucci, G Annunziato, S Marchianò, M Bordoni, ...
Nutrients 11 (8), 1820, 2019
242019
Unbinding of translocator protein 18 kDa (TSPO) ligands: from in vitro residence time to in vivo efficacy via in silico simulations
A Bruno, E Barresi, N Simola, E Da Pozzo, B Costa, E Novellino, ...
ACS Chemical Neuroscience 10 (8), 3805-3814, 2019
232019
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