| Click chemistry reactions in medicinal chemistry: Applications of the 1, 3‐dipolar cycloaddition between azides and alkynes GC Tron, T Pirali, RA Billington, PL Canonico, G Sorba, AA Genazzani Medicinal research reviews 28 (2), 278-308, 2008 | 1300 | 2008 |
| Medicinal chemistry of combretastatin A4: present and future directions GC Tron, T Pirali, G Sorba, F Pagliai, S Busacca, AA Genazzani Journal of medicinal chemistry 49 (11), 3033-3044, 2006 | 776 | 2006 |
| Applications of deuterium in medicinal chemistry T Pirali, M Serafini, S Cargnin, AA Genazzani Journal of medicinal chemistry 62 (11), 5276-5297, 2019 | 627 | 2019 |
| Rapid synthesis of triazole-modified resveratrol analogues via click chemistry F Pagliai, T Pirali, E Del Grosso, R Di Brisco, GC Tron, G Sorba, ... Journal of medicinal chemistry 49 (2), 467-470, 2006 | 294 | 2006 |
| Deuterium in drug discovery: progress, opportunities and challenges RMC Di Martino, BD Maxwell, T Pirali Nature Reviews Drug Discovery 22 (7), 562-584, 2023 | 187 | 2023 |
| One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+ 2] cycloaddition T Pirali, GC Tron, J Zhu Organic Letters 8 (18), 4145-4148, 2006 | 169 | 2006 |
| Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1, 5-disubstituted 1, 2, 3-triazole via ruthenium-catalyzed click chemistry D Imperio, T Pirali, U Galli, F Pagliai, L Cafici, PL Canonico, G Sorba, ... Bioorganic & medicinal chemistry 15 (21), 6748-6757, 2007 | 107 | 2007 |
| Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues S Theeramunkong, A Caldarelli, A Massarotti, S Aprile, D Caprioglio, ... Journal of medicinal chemistry 54 (14), 4977-4986, 2011 | 106 | 2011 |
| A mimicry of primary amines by bis-secondary diamines as components in the Ugi four-component reaction GB Giovenzana, GC Tron, S Di Paola, IG Menegotto, T Pirali Angewandte Chemie-International Edition 45 (7), 1099-1102, 2006 | 105 | 2006 |
| Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides R Mossetti, T Pirali, GC Tron, J Zhu Organic Letters 12 (4), 820-823, 2010 | 101 | 2010 |
| A primer of deuterium in drug design S Cargnin, M Serafini, T Pirali Future Medicinal Chemistry 11 (16), 2039-2042, 2019 | 96 | 2019 |
| Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, ... Nature communications 9 (1), 5232, 2018 | 94 | 2018 |
| Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide T Pirali, GC Tron, G Masson, J Zhu Organic Letters 9 (25), 5275-5278, 2007 | 88 | 2007 |
| Transition‐Metal‐Free Direct Arylation of Anilines T Pirali, F Zhang, AH Miller, JL Head, D McAusland, MF Greaney Angewandte Chemie 4 (124), 1030-1033, 2012 | 81 | 2012 |
| A concise entry into nonsymmetrical alkyl polyamines T Pirali, G Callipari, E Ercolano, AA Genazzani, GB Giovenzana, GC Tron Organic letters 10 (19), 4199-4202, 2008 | 62 | 2008 |
| Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents T Pirali, S Busacca, L Beltrami, D Imovilli, F Pagliai, G Miglio, A Massarotti, ... Journal of medicinal chemistry 49 (17), 5372-5376, 2006 | 62 | 2006 |
| Solution-phase parallel synthesis and biological evaluation of combretatriazoles L Cafici, T Pirali, F Condorelli, E Del Grosso, A Massarotti, G Sorba, ... Journal of Combinatorial Chemistry 10 (5), 732-740, 2008 | 61 | 2008 |
| Estrogenic analogues synthesized by click chemistry T Pirali, S Gatti, R Di Brisco, S Tacchi, R Zaninetti, E Brunelli, A Massarotti, ... ChemMedChem: Chemistry Enabling Drug Discovery 2 (4), 437-440, 2007 | 57 | 2007 |
| Discovery of highly potent benzimidazole derivatives as indoleamine 2, 3-dioxygenase-1 (IDO1) inhibitors: from structure-based virtual screening to in vivo pharmacodynamic activity M Serafini, E Torre, S Aprile, ED Grosso, A Gesù, A Griglio, G Colombo, ... Journal of medicinal chemistry 63 (6), 3047-3065, 2020 | 56 | 2020 |
| Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation O Mesenzani, A Massarotti, M Giustiniano, T Pirali, V Bevilacqua, ... Bioorganic & medicinal chemistry letters 21 (2), 764-768, 2011 | 56 | 2011 |
