| Identification of a New Allelic Variant of the Acinetobacter baumannii Cephalosporinase, ADC-7 β-Lactamase: Defining a Unique Family of Class C Enzymes KM Hujer, NS Hamza, AM Hujer, F Perez, MS Helfand, CR Bethel, ... Antimicrobial agents and chemotherapy 49 (7), 2941-2948, 2005 | 279 | 2005 |
| β-Lactamases: a survey of protein diversity MS Helfand, RA Bonomo Current Drug Targets-Infectious Disorders 3 (1), 9-23, 2003 | 155 | 2003 |
| Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 β-lactamase: insights into the mechanism of inhibition D Sulton, D Pagan-Rodriguez, X Zhou, Y Liu, AM Hujer, CR Bethel, ... Journal of Biological Chemistry 280 (42), 35528-35536, 2005 | 102 | 2005 |
| High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 β-lactamase PS Padayatti, MS Helfand, MA Totir, MP Carey, PR Carey, RA Bonomo, ... Journal of Biological Chemistry 280 (41), 34900-34907, 2005 | 100 | 2005 |
| Following the reactions of mechanism-based inhibitors with β-lactamase by Raman crystallography MS Helfand, MA Totir, MP Carey, AM Hujer, RA Bonomo, PR Carey Biochemistry 42 (46), 13386-13392, 2003 | 98 | 2003 |
| β-Lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci LB Rice, RH Thomas, V Lakticova, MS Helfand, CJ Donskey The Journal of infectious diseases 189 (6), 1113-1118, 2004 | 92 | 2004 |
| Tazobactam Forms a Stoichiometric trans-Enamine Intermediate in the E166A Variant of SHV-1 β-Lactamase: 1.63 Å Crystal Structure, PS Padayatti, MS Helfand, MA Totir, MP Carey, AM Hujer, PR Carey, ... Biochemistry 43 (4), 843-848, 2004 | 90 | 2004 |
| Current challenges in antimicrobial chemotherapy: the impact of extended-spectrum β-lactamases and metallo-β-lactamases on the treatment of resistant Gram-negative pathogens MS Helfand, RA Bonomo Current Opinion in Pharmacology 5 (5), 452-458, 2005 | 86 | 2005 |
| Understanding resistance to β-lactams and β-lactamase inhibitors in the SHV β-lactamase: lessons from the mutagenesis of SER-130 MS Helfand, CR Bethel, AM Hujer, KM Hujer, VE Anderson, RA Bonomo Journal of Biological Chemistry 278 (52), 52724-52729, 2003 | 79 | 2003 |
| Rational Design of a β-Lactamase Inhibitor Achieved via Stabilization of the trans-Enamine Intermediate: 1.28 Å Crystal Structure of wt SHV-1 Complex with a … PS Padayatti, A Sheri, MA Totir, MS Helfand, MP Carey, VE Anderson, ... Journal of the American Chemical Society 128 (40), 13235-13242, 2006 | 69 | 2006 |
| Mechanisms by Which Anaerobic Microbiota Inhibit the Establishment in Mice of Intestinal Colonization by Vancomycin-Resistant Enterococcus NJ Pultz, U Stiefel, S Subramanyan, MS Helfand, CJ Donskey The Journal of infectious diseases 191 (6), 949-956, 2005 | 65 | 2005 |
| Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV β-lactamases AM Hujer, MGP Page, MS Helfand, B Yeiser, RA Bonomo Journal of clinical microbiology 40 (6), 1947-1957, 2002 | 65 | 2002 |
| Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 β-lactamase MA Totir, MS Helfand, MP Carey, A Sheri, JD Buynak, RA Bonomo, ... Biochemistry 46 (31), 8980-8987, 2007 | 64 | 2007 |
| Effect of the Inhibitor-Resistant M69V Substitution on the Structures and Populations of trans-Enamine β-Lactamase Intermediates MA Totir, PS Padayatti, MS Helfand, MP Carey, RA Bonomo, PR Carey, ... Biochemistry 45 (39), 11895-11904, 2006 | 62 | 2006 |
| Recurrence of vancomycin-resistant Enterococcus stool colonization during antibiotic therapy CJ Donskey, CK Hoyen, SM Das, MS Helfand, MT Hecker Infection Control & Hospital Epidemiology 23 (8), 436-440, 2002 | 61 | 2002 |
| Penicillin sulfone inhibitors of class D β-lactamases SM Drawz, CR Bethel, VR Doppalapudi, A Sheri, SRR Pagadala, ... Antimicrobial agents and chemotherapy 54 (4), 1414-1424, 2010 | 57 | 2010 |
| Effect of Parenteral Antibiotic Administration on Establishment of Intestinal Colonization by Candida glabrata in Adult Mice NJ Pultz, U Stiefel, M Ghannoum, MS Helfand, CJ Donskey Antimicrobial agents and chemotherapy 49 (1), 438-440, 2005 | 56 | 2005 |
| Enhancing resistance to cephalosporins in class C β-lactamases: impact of Gly214Glu in CMY-2 A Endimiani, Y Doi, CR Bethel, M Taracila, JM Adams-Haduch, A O’Keefe, ... Biochemistry 49 (5), 1014-1023, 2010 | 52 | 2010 |
| Amino acid substitutions at Ambler position Gly238 in the SHV-1 β-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins AM Hujer, KM Hujer, MS Helfand, VE Anderson, RA Bonomo Antimicrobial agents and chemotherapy 46 (12), 3971-3977, 2002 | 51 | 2002 |
| Immune activation, allergic drug toxicity and mortality in HIV-positive tuberculosis RS Wallis, MS Helfand, CC Whalen, JL Johnson, RD Mugerwa, M Vjecha, ... Tubercle and lung disease 77 (6), 516-523, 1996 | 51 | 1996 |
Vernon AndersonConsultant; retired NIH program director; Professor CWRU and Brown UniversityEmail verificata su chop.edu
