| Genome-wide maps of chromatin state in pluripotent and lineage-committed cells TS Mikkelsen, M Ku, DB Jaffe, B Issac, E Lieberman, G Giannoukos, ... Nature 448 (7153), 553-560, 2007 | 4850 | 2007 |
| Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains M Ku, RP Koche, E Rheinbay, EM Mendenhall, M Endoh, TS Mikkelsen, ... PLoS genetics 4 (10), e1000242, 2008 | 1153 | 2008 |
| ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression O Abdel-Wahab, M Adli, LM LaFave, J Gao, T Hricik, AH Shih, S Pandey, ... Cancer cell 22 (2), 180-193, 2012 | 681 | 2012 |
| GC-rich sequence elements recruit PRC2 in mammalian ES cells EM Mendenhall, RP Koche, T Truong, VW Zhou, B Issac, AS Chi, M Ku, ... PLoS genetics 6 (12), e1001244, 2010 | 492 | 2010 |
| Reprogramming factor expression initiates widespread targeted chromatin remodeling RP Koche, ZD Smith, M Adli, H Gu, M Ku, A Gnirke, BE Bernstein, ... Cell stem cell 8 (1), 96-105, 2011 | 424 | 2011 |
| Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo O Abdel-Wahab, J Gao, M Adli, A Dey, T Trimarchi, YR Chung, C Kuscu, ... Journal of Experimental Medicine 210 (12), 2641-2659, 2013 | 358 | 2013 |
| Loss of BAP1 function leads to EZH2-dependent transformation LM LaFave, W Béguelin, R Koche, M Teater, B Spitzer, A Chramiec, ... Nature medicine 21 (11), 1344-1349, 2015 | 354 | 2015 |
| The MicrobesOnline Web site for comparative genomics EJ Alm, KH Huang, MN Price, RP Koche, K Keller, IL Dubchak, AP Arkin Genome research 15 (7), 1015-1022, 2005 | 270 | 2005 |
| Dual targeting of oncogenic activation and inflammatory signaling increases therapeutic efficacy in myeloproliferative neoplasms M Kleppe, R Koche, L Zou, P van Galen, CE Hill, L Dong, S De Groote, ... Cancer cell 33 (1), 29-43. e7, 2018 | 268 | 2018 |
| DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling OA Guryanova, K Shank, B Spitzer, L Luciani, RP Koche, ... Nature medicine 22 (12), 1488-1495, 2016 | 240 | 2016 |
| Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma RP Koche, E Rodriguez-Fos, K Helmsauer, M Burkert, IC MacArthur, ... Nature genetics 52 (1), 29-34, 2020 | 234 | 2020 |
| DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia CW Chen, RP Koche, AU Sinha, AJ Deshpande, N Zhu, R Eng, ... Nature medicine 21 (4), 335-343, 2015 | 230 | 2015 |
| α-Ketoglutarate links p53 to cell fate during tumour suppression JP Morris IV, JJ Yashinskie, R Koche, R Chandwani, S Tian, CC Chen, ... Nature 573 (7775), 595-599, 2019 | 213 | 2019 |
| A UTX-MLL4-p300 transcriptional regulatory network coordinately shapes active enhancer landscapes for eliciting transcription SP Wang, Z Tang, CW Chen, M Shimada, RP Koche, LH Wang, ... Molecular cell 67 (2), 308-321. e6, 2017 | 205 | 2017 |
| Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia MWM Kühn, E Song, Z Feng, A Sinha, CW Chen, AJ Deshpande, ... Cancer discovery 6 (10), 1166-1181, 2016 | 203 | 2016 |
| H2A. Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions M Ku, JD Jaffe, RP Koche, E Rheinbay, M Endoh, H Koseki, SA Carr, ... Genome biology 13, 1-13, 2012 | 198 | 2012 |
| AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes AJ Deshpande, A Deshpande, AU Sinha, L Chen, J Chang, A Cihan, ... Cancer cell 26 (6), 896-908, 2014 | 181 | 2014 |
| Targeting MYCN-driven transcription by BET-bromodomain inhibition A Henssen, K Althoff, A Odersky, A Beckers, R Koche, F Speleman, ... Clinical Cancer Research 22 (10), 2470-2481, 2016 | 180 | 2016 |
| L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer K Ganesh, H Basnet, Y Kaygusuz, AM Laughney, L He, R Sharma, ... Nature cancer 1 (1), 28-45, 2020 | 163 | 2020 |
| A gene–environment-induced epigenetic program initiates tumorigenesis D Alonso-Curbelo, YJ Ho, C Burdziak, JLV Maag, JP Morris IV, ... Nature 590 (7847), 642-648, 2021 | 150 | 2021 |
