| K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac YY Dong, ACW Pike, A Mackenzie, C McClenaghan, P Aryal, L Dong, ... Science 347 (6227), 1256-1259, 2015 | 313 | 2015 |
| Hydrophobic gating in ion channels P Aryal, MSP Sansom, SJ Tucker Journal of molecular biology 427 (1), 121-130, 2015 | 285 | 2015 |
| Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism W Lin, B Dominguez, J Yang, P Aryal, EP Brandon, FH Gage, KF Lee Neuron 46 (4), 569-579, 2005 | 270 | 2005 |
| Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature MC Almeida, T Hew-Butler, RN Soriano, S Rao, W Wang, J Wang, ... Journal of Neuroscience 32 (6), 2086-2099, 2012 | 252 | 2012 |
| A discrete alcohol pocket involved in GIRK channel activation P Aryal, H Dvir, S Choe, PA Slesinger Nature neuroscience 12 (8), 988-995, 2009 | 189 | 2009 |
| Evidence for association of GABAB receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins CE Fowler, P Aryal, KF Suen, PA Slesinger The Journal of physiology 580 (1), 51-65, 2007 | 131 | 2007 |
| A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel P Aryal, F Abd-Wahab, G Bucci, MSP Sansom, SJ Tucker Nature communications 5 (1), 4377, 2014 | 130 | 2014 |
| Regulation of myosin‐VI targeting to endocytic compartments AL Dance, M Miller, S Seragaki, P Aryal, B White, L Aschenbrenner, ... Traffic 5 (10), 798-813, 2004 | 116 | 2004 |
| Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo JJ Martindale, JA Wall, DM Martinez-Longoria, P Aryal, HA Rockman, ... Journal of Biological Chemistry 280 (1), 669-676, 2005 | 98 | 2005 |
| Kir channel modulators SD Pegan, PA Slesinger, S Choe, P Aryal US Patent 8,097,422, 2012 | 84 | 2012 |
| Bilayer-mediated structural transitions control mechanosensitivity of the TREK-2 K2P channel P Aryal, V Jarerattanachat, MV Clausen, M Schewe, C McClenaghan, ... Structure 25 (5), 708-718. e2, 2017 | 76 | 2017 |
| Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy DT Lucas, P Aryal, LI Szweda, WJ Koch, LA Leinwand American Journal of Physiology-Heart and Circulatory Physiology 284 (2 …, 2003 | 76 | 2003 |
| Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states C McClenaghan, M Schewe, P Aryal, EP Carpenter, T Baukrowitz, ... Journal of General Physiology 147 (6), 497-505, 2016 | 72 | 2016 |
| Functional annotation of ion channel structures by molecular simulation JL Trick, S Chelvaniththilan, G Klesse, P Aryal, EJ Wallace, SJ Tucker, ... Structure 24 (12), 2207-2216, 2016 | 62 | 2016 |
| Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms MC An, W Lin, J Yang, B Dominguez, D Padgett, Y Sugiura, P Aryal, ... Proceedings of the National Academy of Sciences 107 (23), 10702-10707, 2010 | 46 | 2010 |
| Lipid interactions of a ciliary membrane TRP channel: simulation and structural studies of polycystin-2 Q Wang, RA Corey, G Hedger, P Aryal, M Grieben, C Nasrallah, ... Structure 28 (2), 169-184. e5, 2020 | 38 | 2020 |
| Dynamic role of the tether helix in PIP2-dependent gating of a G protein–gated potassium channel E Lacin, P Aryal, IW Glaaser, K Bodhinathan, E Tsai, N Marsh, SJ Tucker, ... Journal of General Physiology 149 (8), 799-811, 2017 | 33 | 2017 |
| Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel P Aryal, F Abd-Wahab, G Bucci, MSP Sansom, SJ Tucker Channels 9 (1), 44-49, 2015 | 27 | 2015 |
| Molecular simulation studies of hydrophobic gating in nanopores and ion channels JL Trick, P Aryal, SJ Tucker, MSP Sansom Biochemical Society Transactions 43 (2), 146-150, 2015 | 26 | 2015 |
| The effects of stretch activation on ionic selectivity of the TREK-2 K2P K+ channel E Nematian-Ardestani, V Jarerattanachat, P Aryal, MSP Sansom, ... Channels 11 (5), 482-486, 2017 | 8 | 2017 |
Senyon ChoeProfessor of Structural Biology, Salk InstituteVerified email at salk.edu
