| erbB-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells PP Di Fiore, JH Pierce, MH Kraus, O Segatto, CR King, SA Aaronson Science 237 (4811), 178-182, 1987 | 1380 | 1987 |
| Different Structural Alterations Upregulate In Vitro Tyrosine Kinase Activity and Transforming Potency of the erbB-2 Gene O Segatto, CR King, JH Pierce, PP Di Fiore, SA Aaronson Molecular and cellular biology 8 (12), 5570-5574, 1988 | 268 | 1988 |
| The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand. F Lonardo, E Di Marco, CR King, JH Pierce, O Segatto, SA Aaronson, ... The New Biologist 2 (11), 992-1003, 1990 | 224 | 1990 |
| EGF Receptor and erbB-2 Tyrosine Kinase Domains Confer Cell Specificity for Mitogenic Signaling PP Di Fiore, O Segatto, WG Taylor, SA Aaronson, JH Pierce Science 248 (4951), 79-83, 1990 | 183 | 1990 |
| Constitutive phosphorylation of Shc proteins in human tumors. G Pelicci, L Lanfrancone, AE Salcini, A Romano, S Mele, G Borrello, ... Oncogene 11 (5), 899-907, 1995 | 181 | 1995 |
| Shc products are substrates of erbB-2 kinase. O Segatto, G Pelicci, S Giuli, G Digiesi, PP Di Fiore, J McGlade, T Pawson, ... Oncogene 8 (8), 2105-2112, 1993 | 169 | 1993 |
| Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain L Fiorentino, C Pertica, M Fiorini, C Talora, M Crescenzi, L Castellani, ... Molecular and cellular biology 20 (20), 7735-7750, 2000 | 165 | 2000 |
| Changes in expression of α6/β 4 integrin heterodimer in primary and metastatic breast cancer PG Natali, MR Nicotra, C Botti, M Mottolese, A Bigotti, O Segatto British journal of cancer 66 (2), 318-322, 1992 | 155 | 1992 |
| Mig-6 controls EGFR trafficking and suppresses gliomagenesis H Ying, H Zheng, K Scott, R Wiedemeyer, H Yan, C Lim, J Huang, ... Proceedings of the National Academy of Sciences 107 (15), 6912-6917, 2010 | 145 | 2010 |
| Feedback inhibition by RALT controls signal output by the ErbB network S Anastasi, L Fiorentino, M Fiorini, R Fraioli, G Sala, L Castellani, S Alema, ... Oncogene 22 (27), 4221-4234, 2003 | 144 | 2003 |
| Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin S Anastasi, G Sala, C Huiping, E Caprini, G Russo, S Iacovelli, F Lucini, ... Oncogene 24 (28), 4540-4548, 2005 | 139 | 2005 |
| A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation Y Frosi, S Anastasi, C Ballarò, G Varsano, L Castellani, E Maspero, ... Journal of cell biology 189 (3), 557-571, 2010 | 128 | 2010 |
| Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors O Segatto, S Anastasi, S Alemà Journal of cell science 124 (11), 1785-1793, 2011 | 127 | 2011 |
| Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways C Talora, S Cialfi, O Segatto, S Morrone, JK Choi, L Frati, GP Dotto, ... Experimental cell research 305 (2), 343-354, 2005 | 125 | 2005 |
| The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-γ and GTPase-activating protein does not correlate with erbB-2 mitogenic potency F Fazioli, UH Kim, SG Rhee, CJ Molloy, O Segatto, PP Di Fiore Molecular and cellular biology, 1991 | 107 | 1991 |
| Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase. A Ricci, L Lanfrancone, R Chiari, G Belardo, C Pertica, PG Natali, ... Oncogene 11 (8), 1519-1529, 1995 | 102 | 1995 |
| The role of autophosphorylation in modulation of erbB-2 transforming function. O Segatto, F Lonardo, JH Pierce, DP Bottaro, PP Di Fiore The New biologist 2 (2), 187-195, 1990 | 99 | 1990 |
| Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control M Fiorini, C Ballaro, G Sala, G Falcone, S Alema, O Segatto Oncogene 21 (42), 6530-6539, 2002 | 89 | 2002 |
| The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming … PP Di Fiore, O Segatto, F Lonardo, F Fazioli, JH Pierce, SAA Aronson Molecular and cellular biology, 1990 | 88 | 1990 |
| The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells. E Finzi, T Fleming, O Segatto, CY Pennington, TS Bringman, R Derynck, ... Proceedings of the National Academy of Sciences 84 (11), 3733-3737, 1987 | 88 | 1987 |
