| Superoxide activates mitochondrial uncoupling proteins KS Echtay, D Roussel, J St-Pierre, MB Jekabsons, S Cadenas, JA Stuart, ... Nature 415 (6867), 96-99, 2002 | 1468 | 2002 |
| Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean JC Clapham, JRS Arch, H Chapman, A Haynes, C Lister, GBT Moore, ... Nature 406 (6794), 415-418, 2000 | 693 | 2000 |
| Hypothalamic orexin expression: modulation by blood glucose and feeding. XJ Cai, PS Widdowson, J Harrold, S Wilson, RE Buckingham, JR Arch, ... Diabetes 48 (11), 2132-2137, 1999 | 350 | 1999 |
| Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal … PW Young, DR Buckle, BCC Cantello, H Chapman, JC Clapham, ... Journal of Pharmacology and Experimental Therapeutics 284 (2), 751-759, 1998 | 317 | 1998 |
| Peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats RE Buckingham, KA Al-Barazanji, CDN Toseland, M Slaughter, ... Diabetes 47 (8), 1326-1334, 1998 | 268 | 1998 |
| Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity JR Speakman, DA Levitsky, DB Allison, MS Bray, JM De Castro, DJ Clegg, ... Disease models & mechanisms 4 (6), 733-745, 2011 | 245 | 2011 |
| Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice GBT Moore, H Chapman, JC Holder, CA Lister, V Piercy, SA Smith, ... Biochemical and biophysical research communications 286 (4), 735-741, 2001 | 239 | 2001 |
| The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3 S Cadenas, KS Echtay, JA Harper, MB Jekabsons, JA Buckingham, ... Journal of Biological Chemistry 277 (4), 2773-2778, 2002 | 220 | 2002 |
| Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3 MD Brand, R Pamplona, M Portero-Otín, JR Requena, SJ Roebuck, ... Biochemical Journal 368 (2), 597-603, 2002 | 207 | 2002 |
| Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice AC Haynes, H Chapman, C Taylor, GBT Moore, MA Cawthorne, ... Regulatory peptides 104 (1-3), 153-159, 2002 | 168 | 2002 |
| Anti-obesity drugs: a critical review of current therapies and future opportunities JC Clapham, JRS Arch, M Tadayyon Pharmacology & therapeutics 89 (1), 81-121, 2001 | 142 | 2001 |
| BRL 34915, a novel antihypertensive agent: comparison of effects on blood pressure and other haemodynamic parameters with those of nifedipine in animal models. RE Buckingham, JC Clapham, TC Hamilton, SD Longman, J Norton, ... Journal of cardiovascular pharmacology 8 (4), 798, 1986 | 128 | 1986 |
| Liver‐directed overexpression of mitochondrial glycerol‐3‐phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid … D Lindén, L William‐Olsson, A Ahnmark, K Ekroos, C Hallberg, ... The FASEB Journal 20 (3), 434-443, 2006 | 118 | 2006 |
| Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter NJ Pearce, JRS Arch, JC Clapham, MP Coghlan, SL Corcoran, CA Lister, ... Metabolism 53 (10), 1322-1330, 2004 | 114 | 2004 |
| Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis D Lindén, L William-Olsson, M Rhedin, AK Asztély, JC Clapham, ... Journal of lipid research 45 (7), 1279-1288, 2004 | 99 | 2004 |
| Central control of thermogenesis JC Clapham Neuropharmacology 63 (1), 111-123, 2012 | 96 | 2012 |
| Insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes, pathologic mechanisms and treatment: current status and therapeutic possibilities NC Turner, JC Clapham Progress in drug research, 33-94, 1998 | 91 | 1998 |
| DPP‐IV inhibition enhances the antilipolytic action of NPY in human adipose tissue K Kos, AR Baker, M Jernas, AL Harte, JC Clapham, JP O’Hare, ... Diabetes, Obesity and Metabolism 11 (4), 285-292, 2009 | 85 | 2009 |
| The Thiazolidinedione Insulin Sensitiser, BRL 49653, Increases the Expression of PPAR-γ and aP2in Adipose Tissue of High-Fat-Fed Rats SL Pearson, MA Cawthorne, JC Clapham, SJ Dunmore, SD Holmes, ... Biochemical and biophysical research communications 229 (3), 752-757, 1996 | 84 | 1996 |
| Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle S Wang, A Subramaniam, MA Cawthorne, JC Clapham Diabetes, Obesity and Metabolism 5 (5), 295-301, 2003 | 83 | 2003 |
