Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins NB Nillegoda, MA Theodoraki, AK Mandal, KJ Mayo, HY Ren, R Sultana, ... Molecular biology of the cell 21 (13), 2102-2116, 2010 | 169 | 2010 |
Amyloid in neurodegenerative diseases: friend or foe? KJ Wolfe, DM Cyr Seminars in cell & developmental biology 22 (5), 476-481, 2011 | 105 | 2011 |
The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein DW Summers, KJ Wolfe, HY Ren, DM Cyr PloS one 8 (1), e52099, 2013 | 95 | 2013 |
Transcription errors induce proteotoxic stress and shorten cellular lifespan M Vermulst, AS Denney, MJ Lang, CW Hung, S Moore, MA Moseley, ... Nature communications 6 (1), 8065, 2015 | 93 | 2015 |
The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins KJ Wolfe, HY Ren, P Trepte, DM Cyr Molecular biology of the cell 24 (23), 3588-3602, 2013 | 71 | 2013 |
IκB kinase β inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells EA Duncan, CA Goetz, SJ Stein, KJ Mayo, BJ Skaggs, K Ziegelbauer, ... Molecular cancer therapeutics 7 (2), 391-397, 2008 | 33 | 2008 |
Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins KJ Wolfe, HY Ren, P Trepte, DM Cyr PloS one 9 (5), e95914, 2014 | 22 | 2014 |
Protein aggregation and neurodegeneration KJ Mayo, DM Cyr Methods (San Diego, Calif.) 53 (3), 185, 2011 | 3 | 2011 |
Correction: Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan M Vermulst, AS Denney, MJ Lang, CW Hung, S Moore, MA Moseley, ... Nature Communications 6 (1), 1-1, 2015 | 1 | 2015 |
Chaperone Mediated Protective Protein Aggregation and Spatial Quality Control KJ Wolfe University of North Carolina at Chapel Hill, 2013 | | 2013 |
Alteration of Hsp70 co-chaperone levels suppresses amyloid-like protein proteotoxicity by increasing the cells capacity to sequester polyQ into benign aggregates KJ Wolfe, H Ren, D Cyr MOLECULAR BIOLOGY OF THE CELL 23, 2012 | | 2012 |
Chaperone‐Dependent Amyloid Assembly and Prion Toxicity DW Summers, KJ Wolfe, DM Cyr Protein Chaperones and Protection from Neurodegenerative Diseases, 261-276, 2011 | | 2011 |