Frank Furnari
Frank Furnari
Ludwig Institute
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Malignant astrocytic glioma: genetics, biology, and paths to treatment
FB Furnari, T Fenton, RM Bachoo, A Mukasa, JM Stommel, A Stegh, ...
Genes & development 21 (21), 2683-2710, 2007
Malignant glioma: genetics and biology of a grave matter
EA Maher, FB Furnari, RM Bachoo, DH Rowitch, DN Louis, WK Cavenee, ...
Genes & development 15 (11), 1311-1333, 2001
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
T Gao, F Furnari, AC Newton
Molecular cell 18 (1), 13-24, 2005
Emerging insights into the molecular and cellular basis of glioblastoma
GP Dunn, ML Rinne, J Wykosky, G Genovese, SN Quayle, IF Dunn, ...
Genes & development 26 (8), 756-784, 2012
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
JC Sok, FM Coppelli, SM Thomas, MN Lango, S Xi, JL Hunt, ML Freilino, ...
Clinical Cancer Research 12 (17), 5064-5073, 2006
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
FB Furnari, HJS Huang, WK Cavenee
Cancer research 58 (22), 5002-5008, 1998
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
FB Furnari, H Lin, HJS Huang, WK Cavenee
Proceedings of the National Academy of Sciences 94 (23), 12479-12484, 1997
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
R Bonavia, A Mukasa, Y Narita, DWY Sah, S Vandenberg, C Brennan, ...
Genes & development 24 (16), 1731-1745, 2010
Heterogeneity maintenance in glioblastoma: a social network
R Bonavia, WK Cavenee, FB Furnari
Cancer research 71 (12), 4055-4060, 2011
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
PH Huang, A Mukasa, R Bonavia, RA Flynn, ZE Brewer, WK Cavenee, ...
Proceedings of the National Academy of Sciences 104 (31), 12867-12872, 2007
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA
DA Nathanson, B Gini, J Mottahedeh, K Visnyei, T Koga, G Gomez, ...
Science 343 (6166), 72-76, 2014
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
KM Turner, V Deshpande, D Beyter, T Koga, J Rusert, C Lee, B Li, ...
Nature 543 (7643), 122-125, 2017
Dynamics of centromere and kinetochore proteins: implications for checkpoint signaling and silencing
JV Shah, E Botvinick, Z Bonday, F Furnari, M Berns, DW Cleveland
Current biology 14 (11), 942-952, 2004
EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma
B Mukherjee, B McEllin, CV Camacho, N Tomimatsu, S Sirasanagandala, ...
Cancer research 69 (10), 4252-4259, 2009
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma
FB Furnari, TF Cloughesy, WK Cavenee, PS Mischel
Nature Reviews Cancer 15 (5), 302-310, 2015
Cancer-associated protein kinase C mutations reveal kinase’s role as tumor suppressor
CE Antal, AM Hudson, E Kang, C Zanca, C Wirth, NL Stephenson, ...
Cell 160 (3), 489-502, 2015
PCAF Modulates PTEN Activity*♦
K Okumura, M Mendoza, RM Bachoo, RA DePinho, WK Cavenee, ...
Journal of Biological Chemistry 281 (36), 26562-26568, 2006
Replacement of the p16/CDKN2 gene suppresses human glioma cell growth
W Arap, R Nishikawa, FB Furnari, WK Cavenee, HJS Huang
Cancer Research 55 (6), 1351-1354, 1995
Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance
T E Taylor, F B Furnari, W K Cavenee
Current cancer drug targets 12 (3), 197-209, 2012
Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas
Y Narita, M Nagane, K Mishima, HJS Huang, FB Furnari, WK Cavenee
Cancer research 62 (22), 6764-6769, 2002
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