Nicole Kleinstreuer
Nicole Kleinstreuer
NICEATM Director (Acting)
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Citata da
Citata da
Chronic inflammation in the etiology of disease across the life span
D Furman, J Campisi, E Verdin, P Carrera-Bastos, S Targ, C Franceschi, ...
Nature medicine 25 (12), 1822-1832, 2019
Update on EPA’s ToxCast program: providing high throughput decision support tools for chemical risk management
R Kavlock, K Chandler, K Houck, S Hunter, R Judson, N Kleinstreuer, ...
Chemical research in toxicology 25 (7), 1287-1302, 2012
Zebrafish developmental screening of the ToxCast™ Phase I chemical library
S Padilla, D Corum, B Padnos, DL Hunter, A Beam, KA Houck, N Sipes, ...
Reproductive toxicology 33 (2), 174-187, 2012
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
WH Goodson III, L Lowe, DO Carpenter, M Gilbertson, A Manaf Ali, ...
Carcinogenesis 36 (Suppl_1), S254-S296, 2015
Screening chemicals for estrogen receptor bioactivity using a computational model
P Browne, RS Judson, WM Casey, NC Kleinstreuer, RS Thomas
Environmental science & technology 49 (14), 8804-8814, 2015
Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
NS Sipes, MT Martin, DM Reif, NC Kleinstreuer, RS Judson, AV Singh, ...
Toxicological Sciences 124 (1), 109-127, 2011
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space
R Judson, K Houck, M Martin, AM Richard, TB Knudsen, I Shah, S Little, ...
Toxicological Sciences 152 (2), 323-339, 2016
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
NC Kleinstreuer, J Yang, EL Berg, TB Knudsen, AM Richard, MT Martin, ...
Nature biotechnology 32 (6), 583-591, 2014
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
TB Knudsen, KA Houck, NS Sipes, AV Singh, RS Judson, MT Martin, ...
Toxicology 282 (1-2), 1-15, 2011
Integrated testing strategies (ITS) for safety assessment
C Rovida, M Daneshian, T Hartung
Alternatives to animal experimentation: ALTEX 32 (1), 25-40, 2015
T4 report: Toward good read-across practice (GRAP) guidance
N Ball, MTD Cronin, J Shen, K Blackburn, ED Booth, M Bouhifd, E Donley, ...
Altex 33 (2), 149, 2016
Development and validation of a computational model for androgen receptor activity
NC Kleinstreuer, P Ceger, ED Watt, M Martin, K Houck, P Browne, ...
Chemical research in toxicology 30 (4), 946-964, 2017
Environmental impact on vascular development predicted by high-throughput screening
NC Kleinstreuer, RS Judson, DM Reif, NS Sipes, AV Singh, KJ Chandler, ...
Environmental health perspectives 119 (11), 1596-1603, 2011
In vitro to in vivo extrapolation for high throughput prioritization and decision making
SM Bell, X Chang, JF Wambaugh, DG Allen, M Bartels, KLR Brouwer, ...
Toxicology in vitro 47, 213-227, 2018
A computational model predicting disruption of blood vessel development
N Kleinstreuer, D Dix, M Rountree, N Baker, N Sipes, D Reif, R Spencer, ...
PLoS computational biology 9 (4), e1002996, 2013
Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics
NC Kleinstreuer, AM Smith, PR West, KR Conard, BR Fontaine, ...
Toxicology and applied pharmacology 257 (1), 111-121, 2011
Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database
S Hoffmann, N Kleinstreuer, N Alpe, D Allen, AM Api, T Ashikaga, ...
Critical reviews in toxicology 48 (5), 344-358, 2018
Non-animal methods to predict skin sensitization (II): an assessment of defined approaches
NC Kleinstreuer, S Hoffmann, N Alpe, D Allen, T Ashikaga, W Casey, ...
Critical reviews in toxicology 48 (5), 359-374, 2018
Integrated decision strategies for skin sensitization hazard
J Strickland, Q Zang, N Kleinstreuer, M Paris, DM Lehmann, N Choksi, ...
Journal of Applied Toxicology 36 (9), 1150-1162, 2016
In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis
NC Kleinstreuer, DJ Dix, KA Houck, RJ Kavlock, TB Knudsen, MT Martin, ...
toxicological sciences 131 (1), 40-55, 2013
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