| The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation GC Meacham, C Patterson, W Zhang, JM Younger, DM Cyr Nature cell biology 3 (1), 100-105, 2001 | 1022 | 2001 |
| CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation J Jiang, CA Ballinger, Y Wu, Q Dai, DM Cyr, J Höhfeld, C Patterson Journal of Biological Chemistry 276 (46), 42938-42944, 2001 | 710 | 2001 |
| DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70 DM Cyr, T Langer, MG Douglas Trends in biochemical sciences 19 (4), 176-181, 1994 | 638 | 1994 |
| The J‐protein family: modulating protein assembly, disassembly and translocation P Walsh, D Bursać, YC Law, D Cyr, T Lithgow EMBO reports 5 (6), 567-571, 2004 | 611 | 2004 |
| From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations G Veit, RG Avramescu, AN Chiang, SA Houck, Z Cai, KW Peters, JS Hong, ... Molecular biology of the cell 27 (3), 424-433, 2016 | 576 | 2016 |
| Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator JM Younger, L Chen, HY Ren, MFN Rosser, EL Turnbull, CY Fan, ... Cell 126 (3), 571-582, 2006 | 500 | 2006 |
| Mechanisms for regulation of Hsp70 function by Hsp40 CY Fan, S Lee, DM Cyr Cell stress & chaperones 8 (4), 309, 2003 | 447 | 2003 |
| Protein quality control: U-box-containing E3 ubiquitin ligases join the fold DM Cyr, J Höhfeld, C Patterson Trends in biochemical sciences 27 (7), 368-375, 2002 | 442 | 2002 |
| From the cradle to the grave: molecular chaperones that may choose between folding and degradation J Höhfeld, DM Cyr, C Patterson EMBO reports, 2001 | 442 | 2001 |
| The Hdj‐2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis GC Meacham, Z Lu, S King, E Sorscher, A Tousson, DM Cyr The EMBO journal, 1999 | 415 | 1999 |
| CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70 SB Qian, H McDonough, F Boellmann, DM Cyr, C Patterson Nature 440 (7083), 551-555, 2006 | 406 | 2006 |
| YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism AJ Caplan, DM Cyr, MG Douglas Cell 71 (7), 1143-1155, 1992 | 387 | 1992 |
| CHIP activates HSF1 and confers protection against apoptosis and cellular stress Q Dai, C Zhang, Y Wu, H McDonough, RA Whaley, V Godfrey, HH Li, ... The EMBO journal 22 (20), 5446-5458, 2003 | 367 | 2003 |
| Regulation of Hsp70 function by a eukaryotic DnaJ homolog. DM Cyr, X Lu, MG Douglas Journal of Biological Chemistry 267 (29), 20927-20931, 1992 | 342 | 1992 |
| The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria C Ungermann, W Neupert, DM Cyr Science 266 (5188), 1250-1253, 1994 | 324 | 1994 |
| VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1 HY Ren, DE Grove, O De La Rosa, SA Houck, P Sopha, F Van Goor, ... Molecular biology of the cell 24 (19), 3016-3024, 2013 | 320 | 2013 |
| Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins. AJ Caplan, DM Cyr, MG Douglas Molecular biology of the cell 4 (6), 555-563, 1993 | 297 | 1993 |
| Protein folding activity of Hsp70 is modified differentially by the hsp40 co-chaperones Sis1 and Ydj1 Z Lu, DM Cyr Journal of Biological Chemistry 273 (43), 27824-27830, 1998 | 275 | 1998 |
| Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRΔF508 D Morito, K Hirao, Y Oda, N Hosokawa, F Tokunaga, DM Cyr, K Tanaka, ... Molecular biology of the cell 19 (4), 1328-1336, 2008 | 259 | 2008 |
| Mitochondrial molecular chaperones: their role in protein translocation RA Stuart, DM Cyr, EA Craig, W Neupert Trends in biochemical sciences 19 (2), 87-92, 1994 | 241 | 1994 |
Daniel Summers Ph.D.Assistant Professor - Department of Biology - University of IowaEmail verificata su uiowa.edu
