Segui
Hongliang Zhao
Hongliang Zhao
Thayer School of Engineering at Dartmouth College
Email verificata su dartmouth.edu
Titolo
Citata da
Citata da
Anno
Increasing the homogeneity, stability and activity of human serum albumin and interferon-α2b fusion protein by linker engineering
HL Zhao, XQ Yao, C Xue, Y Wang, XH Xiong, ZM Liu
Protein expression and purification 61 (1), 73-77, 2008
1972008
Enhanced Secretion of Heterologous Proteins in Pichia pastoris Following Overexpression of Saccharomyces cerevisiae Chaperone Proteins
W Zhang, H Zhao, C Xue, X Xiong, X Yao, X Li, H Chen, Z Liu
Biotechnology progress 22 (4), 1090-1095, 2006
1092006
Circumventing the heterogeneity and instability of human serum albumin-interferon-α2b fusion protein by altering its orientation
HL Zhao, C Xue, Y Wang, XY Li, XH Xiong, XQ Yao, ZM Liu
Journal of biotechnology 131 (3), 245-252, 2007
632007
Depletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo
H Zhao, D Verma, W Li, Y Choi, C Ndong, SN Fiering, C Bailey-Kellogg, ...
Chemistry & biology 22 (5), 629-639, 2015
562015
Increasing the cell viability and heterologous protein expression of Pichia pastoris mutant deficient in PMR1 gene by culture condition optimization
HL Zhao, C Xue, Y Wang, XQ Yao, ZM Liu
Applied microbiology and biotechnology 81, 235-241, 2008
472008
Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance
K Blazanovic, H Zhao, Y Choi, W Li, RS Salvat, DC Osipovitch, J Fields, ...
Molecular therapy Methods & clinical development 2, 2015
432015
Gene and protein sequence optimization for high-level production of fully active and aglycosylated lysostaphin in Pichia pastoris
H Zhao, K Blazanovic, Y Choi, C Bailey-Kellogg, KE Griswold
Applied and environmental microbiology 80 (9), 2746-2753, 2014
412014
Elimination of the free sulfhydryl group in the human serum albumin (HSA) moiety of human interferon-α2b and HSA fusion protein increases its stability against mechanical and …
HL Zhao, C Xue, Y Wang, B Sun, XQ Yao, ZM Liu
European journal of pharmaceutics and biopharmaceutics 72 (2), 405-411, 2009
352009
Degradation of HSA-AX15 (R13K) when expressed in Pichia pastoris can be reduced via the disruption of YPS1 gene in this yeast
XQ Yao, HL Zhao, C Xue, W Zhang, XH Xiong, ZW Wang, XY Li, ZM Liu
Journal of biotechnology 139 (2), 131-136, 2009
332009
Balancing the pharmacokinetics and pharmacodynamics of interferon-α2b and human serum albumin fusion protein by proteolytic or reductive cleavage increases its in vivo …
HL Zhao, C Xue, JL Du, M Ren, S Xia, ZM Liu
Molecular Pharmaceutics 9 (3), 664-670, 2012
322012
Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing
H Zhao, SA Brooks, S Eszterhas, S Heim, L Li, YQ Xiong, Y Fang, ...
Science advances 6 (36), eabb9011, 2020
262020
Sustained and cancer cell targeted cytosolic delivery of Onconase results in potent antitumor effects
HL Zhao, C Xue, JL Du, M Ren, S Xia, YG Cheng, ZM Liu
Journal of controlled release 159 (3), 346-352, 2012
222012
Recombinant heat shock protein 65 carrying hepatitis B core antigen induces HBcAg-specific CTL response
B Yang, H Zhao, C Xue, X Xiong, W Zhang, X Yao, Z Liu
Vaccine 25 (22), 4478-4486, 2007
222007
Secretory expression of glycosylated and aglycosylated mutein of onconase from Pichia pastoris using different secretion signals and their purification and …
HL Zhao, Q He, C Xue, B Sun, XQ Yao, ZM Liu
FEMS yeast research 9 (4), 591-599, 2009
202009
Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics
Y Fang, JR Kirsch, L Li, SA Brooks, S Heim, C Tan, S Eszterhas, ...
Antimicrobial Agents and Chemotherapy 65 (3), 10.1128/aac. 01707-20, 2021
112021
Secretory expression and characterization of a recombinant-deleted variant of human hepatocyte growth factor in Pichia pastoris
ZM Liu, HL Zhao, C Xue, BB Deng, W Zhang, XH Xiong, BF Yang, XQ Yao
World Journal of Gastroenterology 11 (45), 7097, 2005
92005
Protein glycoengineering
Z Hongliang, L Zhimin
Zhongguo Sheng wu Gong Cheng za zhi= Journal of Chinese Biotechnology 23 (9 …, 2003
92003
Disruption of Pichia pastoris PMR1 gene decreases its folding capacity on human serum albumin and interferon‐α2b fusion protein
HL Zhao, C Xue, Y Wang, QF Duan, XH Xiong, XQ Yao, ZM Liu
Yeast 25 (4), 279-286, 2008
62008
GC rapid analysis of methanol and ethanol during high cell density culture of recombinant methylotrophic yeast
BB Deng, HQ Feng, C Xue
Chin. Ind. Microbiol 31, 26-29, 2001
62001
Electrostatic-Mediated Affinity Tuning of Lysostaphin Accelerates Bacterial Lysis Kinetics and Enhances In Vivo Efficacy
H Zhao, S Eszterhas, J Furlon, H Cheng, KE Griswold
Antimicrobial Agents and Chemotherapy 65 (4), 10.1128/aac. 02199-20, 2021
42021
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