| Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? V Alterio, A Di Fiore, K D’Ambrosio, CT Supuran, G De Simone Chemical reviews 112 (8), 4421-4468, 2012 | 853 | 2012 |
| Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX V Alterio, M Hilvo, A Di Fiore, CT Supuran, P Pan, S Parkkila, A Scaloni, ... Proceedings of the National Academy of Sciences 106 (38), 16233-16238, 2009 | 425 | 2009 |
| Histone deacetylase and Cullin3–REN KCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation G Canettieri, L Di Marcotullio, A Greco, S Coni, L Antonucci, P Infante, ... Nature cell biology 12 (2), 132-142, 2010 | 284 | 2010 |
| Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes M Hilvo, L Baranauskiene, AM Salzano, A Scaloni, D Matulis, A Innocenti, ... Journal of Biological Chemistry 283 (41), 27799-27809, 2008 | 279 | 2008 |
| Anticancer carbonic anhydrase inhibitors: a patent review (2008–2013) SM Monti, CT Supuran, G De Simone Expert opinion on therapeutic patents 23 (6), 737-749, 2013 | 215 | 2013 |
| Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX V Alterio, RM Vitale, SM Monti, C Pedone, A Scozzafava, A Cecchi, ... Journal of the American Chemical Society 128 (25), 8329-8335, 2006 | 214 | 2006 |
| Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors G De Simone, V Alterio, CT Supuran Expert opinion on drug discovery 8 (7), 793-810, 2013 | 209 | 2013 |
| Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target G De Simone, CT Supuran Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (2), 404-409, 2010 | 194 | 2010 |
| Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies G De Simone, A Di Fiore, V Menchise, C Pedone, J Antel, A Casini, ... Bioorganic & medicinal chemistry letters 15 (9), 2315-2320, 2005 | 175 | 2005 |
| Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a d-lysine-based chiral PNA–DNA duplex V Menchise, G De Simone, T Tedeschi, R Corradini, S Sforza, R Marchelli, ... Proceedings of the National Academy of Sciences 100 (21), 12021-12026, 2003 | 171 | 2003 |
| Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant … V Menchise, G De Simone, V Alterio, A Di Fiore, C Pedone, A Scozzafava, ... Journal of medicinal chemistry 48 (18), 5721-5727, 2005 | 169 | 2005 |
| Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity CT Supuran, AD Fiore, GD Simone Expert opinion on emerging drugs 13 (2), 383-392, 2008 | 165 | 2008 |
| The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus G De Simone, V Menchise, G Manco, L Mandrich, N Sorrentino, D Lang, ... Journal of molecular biology 314 (3), 507-518, 2001 | 156 | 2001 |
| (In) organic anions as carbonic anhydrase inhibitors G De Simone, CT Supuran Journal of inorganic biochemistry 111, 117-129, 2012 | 151 | 2012 |
| Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? GD Simone, AD Fiore, CT Supuran Current pharmaceutical design 14 (7), 655-660, 2008 | 149 | 2008 |
| A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase G De Simone, S Galdiero, G Manco, D Lang, M Rossi, C Pedone Journal of molecular biology 303 (5), 761-771, 2000 | 144 | 2000 |
| Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: three for the price of one CT Supuran, V Alterio, A Di Fiore, K D’Ambrosio, F Carta, SM Monti, ... Medicinal research reviews 38 (6), 1799-1836, 2018 | 120 | 2018 |
| 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity MP Leese, B Leblond, A Smith, SP Newman, A Di Fiore, G De Simone, ... Journal of medicinal chemistry 49 (26), 7683-7696, 2006 | 109 | 2006 |
| Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates A Innocenti, A Scozzafava, S Parkkila, L Puccetti, G De Simone, ... Bioorganic & medicinal chemistry letters 18 (7), 2267-2271, 2008 | 105 | 2008 |
| Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII OO Guler, GD Simone, CT Supuran Current medicinal chemistry 17 (15), 1516-1526, 2010 | 102 | 2010 |
Claudiu T. SupuranResearcher, Universita di FirenzeEmail verificata su unifi.it
