Nicole G. H. Leferink
Nicole G. H. Leferink
Research Fellow Future BRH, Manchester Intsitute of Biotechnology (MIB), University of Manchester
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Citata da
Citata da
3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities
RK Kuipers, HJ Joosten, WJH Van Berkel, NGH Leferink, E Rooijen, ...
Proteins: Structure, Function, and Bioinformatics 78 (9), 2101-2113, 2010
The growing VAO flavoprotein family
NGH Leferink, DPHM Heuts, MW Fraaije, WJH van Berkel
Archives of biochemistry and biophysics 474 (2), 292-301, 2008
l‐Galactono‐γ‐lactone dehydrogenase from Arabidopsis thaliana, a flavoprotein involved in vitamin C biosynthesis
NGH Leferink, WAM van den Berg, WJH van Berkel
The FEBS journal 275 (4), 713-726, 2008
Identification of a Gatekeeper Residue That Prevents Dehydrogenases from Acting as Oxidases*♦
NGH Leferink, MW Fraaije, HJ Joosten, PJ Schaap, A Mattevi, ...
Journal of Biological Chemistry 284 (7), 4392-4397, 2009
Correlated mutation analyses on super‐family alignments reveal functionally important residues
RKP Kuipers, HJ Joosten, E Verwiel, S Paans, J Akerboom, ...
Proteins: Structure, Function, and Bioinformatics 76 (3), 608-616, 2009
Occurrence and biocatalytic potential of carbohydrate oxidases
EW van Hellemond, NGH Leferink, DPHM Heuts, MW Fraaije, ...
Advances in applied microbiology 60, 17, 2006
Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase
NGH Leferink, C Han, SV Antonyuk, DJ Heyes, SEJ Rigby, MA Hough, ...
Biochemistry 50 (19), 4121-4131, 2011
Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C
NGH Leferink, E Van Duijn, A Barendregt, AJR Heck, WJH Van Berkel
Plant physiology 150 (2), 596-605, 2009
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase
V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ...
Acs Catalysis 7 (9), 6268-6282, 2017
Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures
R Machielsen, NGH Leferink, A Hendriks, SJJ Brouns, HG Hennemann, ...
Extremophiles 12, 587-594, 2008
Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase
NGH Leferink, SV Antonyuk, JA Houwman, NS Scrutton, RR Eady, ...
Nature Communications 5 (1), 4395, 2014
A ‘Plug and Play’ Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli.
NGH Leferink, AJ Jervis, Z Zebec, HS Toogood, S Hay, E Takano, ...
ChemistrySelect 1 (9), 1893-1896, 2016
Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent …
NGH Leferink, CR Pudney, S Brenner, DJ Heyes, RR Eady, SS Hasnain, ...
FEBS letters 586 (5), 578-584, 2012
Energy landscapes and catalysis in nitric-oxide synthase
A Sobolewska-Stawiarz, NGH Leferink, K Fisher, DJ Heyes, S Hay, ...
Journal of Biological Chemistry 289 (17), 11725-11738, 2014
Exploring novel bacterial terpene synthases
GK Reddy, NGH Leferink, M Umemura, ST Ahmed, R Breitling, ...
PloS one 15 (4), e0232220, 2020
Towards the free energy landscape for catalysis in mammalian nitric oxide synthases
NGH Leferink, S Hay, SEJ Rigby, NS Scrutton
The FEBS Journal 282 (16), 3016-3029, 2015
Experiment and simulation reveal how mutations in functional plasticity regions guide plant monoterpene synthase product outcome
NGH Leferink, KE Ranaghan, V Karuppiah, A Currin, MW Van Der Kamp, ...
ACS catalysis 8 (5), 3780-3791, 2018
Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers
ST Ahmed, NGH Leferink, NS Scrutton
Molecular Catalysis 467, 95-110, 2019
Communication between L–galactono–1,4–lactone dehydrogenase and cytochrome c
M Hervás, Q Bashir, NGH Leferink, P Ferreira, B Moreno‐Beltrán, ...
The FEBS journal 280 (8), 1830-1840, 2013
Laser‐flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper‐dependent nitrite reductase
NGH Leferink, RR Eady, SS Hasnain, NS Scrutton
The FEBS Journal 279 (12), 2174-2181, 2012
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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