Nicole G. H. Leferink

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Nigel ScruttonProfessor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of ChemistryEmail verificata su manchester.ac.uk
Sam HayProfessor of Biophysical Chemistry, University of ManchesterEmail verificata su manchester.ac.uk
PJ SchaapAssociate professor, Systems and Synthetic Biology, Wageningen University, The NetherlandsEmail verificata su wur.nl
Henk-Jan JoostenCEOEmail verificata su bio-prodict.nl
Eriko TakanoProfessor of Synthetic Biology, Manchester Institute of Biotechnology, University of ManchesterEmail verificata su manchester.ac.uk
Marco FraaijePhD, BiochemistryEmail verificata su rug.nl
S S HasnainMax Perutz Professor of Molecular Biophysics, University of LiverpoolEmail verificata su liverpool.ac.uk
robert r eadysenior research fellowEmail verificata su liv.ac.uk
Vriend GProfessor Bioinformatics RadboudUMC NijmegenEmail verificata su radboudumc.nl
Derren HeyesManchester Institute of Biotechnology, University of ManchesterEmail verificata su manchester.ac.uk
Marc van der KampSenior Lecturer, University of BristolEmail verificata su bris.ac.uk
Vijaykumar KaruppiahImmunocoreEmail verificata su immunocore.com
Adrian MulhollandProfessor of Chemistry, University of BristolEmail verificata su bristol.ac.uk
John van der OostMicrobiology, Wageningen UniversityEmail verificata su wur.nl
Svetlana AntonyukUniversity of LiverpoolEmail verificata su liverpool.ac.uk
Uwe BornscheuerProfessor, Biotechnology and Enzyme Catalysis, Greifswald UniversityEmail verificata su uni-greifswald.de
Adrian J JervisUniversity of ManchesterEmail verificata su manchester.ac.uk
Linus JohannissenUniversity of ManchesterEmail verificata su manchester.ac.uk
Marcellus UbbinkProfessor of Protein Chemistry, Leiden UniversityEmail verificata su chem.leidenuniv.nl
Qamar BashirNew York State Department of HealthEmail verificata su health.ny.gov

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Nicole G. H. Leferink

Research Fellow Future BRH, Manchester Intsitute of Biotechnology (MIB), University of Manchester

Email verificata su manchester.ac.uk - Home page

Biochemistry molecular enzymology protein engineering biocatalysis synthetic biology


Titolo Ordina per citazioni Ordina per anno Ordina per titolo	Citata da Citata da	Anno
3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities RK Kuipers, HJ Joosten, WJH Van Berkel, NGH Leferink, E Rooijen, ... Proteins: Structure, Function, and Bioinformatics 78 (9), 2101-2113, 2010	177	2010
The growing VAO flavoprotein family NGH Leferink, DPHM Heuts, MW Fraaije, WJH van Berkel Archives of biochemistry and biophysics 474 (2), 292-301, 2008	126	2008
l‐Galactono‐γ‐lactone dehydrogenase from Arabidopsis thaliana, a flavoprotein involved in vitamin C biosynthesis NGH Leferink, WAM van den Berg, WJH van Berkel The FEBS journal 275 (4), 713-726, 2008	99	2008
Identification of a Gatekeeper Residue That Prevents Dehydrogenases from Acting as Oxidases*♦ NGH Leferink, MW Fraaije, HJ Joosten, PJ Schaap, A Mattevi, ... Journal of Biological Chemistry 284 (7), 4392-4397, 2009	95	2009
Correlated mutation analyses on super‐family alignments reveal functionally important residues RKP Kuipers, HJ Joosten, E Verwiel, S Paans, J Akerboom, ... Proteins: Structure, Function, and Bioinformatics 76 (3), 608-616, 2009	86	2009
Occurrence and biocatalytic potential of carbohydrate oxidases EW van Hellemond, NGH Leferink, DPHM Heuts, MW Fraaije, ... Advances in applied microbiology 60, 17, 2006	77	2006
Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase NGH Leferink, C Han, SV Antonyuk, DJ Heyes, SEJ Rigby, MA Hough, ... Biochemistry 50 (19), 4121-4131, 2011	71	2011
Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C NGH Leferink, E Van Duijn, A Barendregt, AJR Heck, WJH Van Berkel Plant physiology 150 (2), 596-605, 2009	51	2009
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ... Acs Catalysis 7 (9), 6268-6282, 2017	48	2017
Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures R Machielsen, NGH Leferink, A Hendriks, SJJ Brouns, HG Hennemann, ... Extremophiles 12, 587-594, 2008	44	2008
Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase NGH Leferink, SV Antonyuk, JA Houwman, NS Scrutton, RR Eady, ... Nature Communications 5 (1), 4395, 2014	42	2014
A ‘Plug and Play’ Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli. NGH Leferink, AJ Jervis, Z Zebec, HS Toogood, S Hay, E Takano, ... ChemistrySelect 1 (9), 1893-1896, 2016	41	2016
Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent … NGH Leferink, CR Pudney, S Brenner, DJ Heyes, RR Eady, SS Hasnain, ... FEBS letters 586 (5), 578-584, 2012	41	2012
Energy landscapes and catalysis in nitric-oxide synthase A Sobolewska-Stawiarz, NGH Leferink, K Fisher, DJ Heyes, S Hay, ... Journal of Biological Chemistry 289 (17), 11725-11738, 2014	34	2014
Exploring novel bacterial terpene synthases GK Reddy, NGH Leferink, M Umemura, ST Ahmed, R Breitling, ... PloS one 15 (4), e0232220, 2020	31	2020
Towards the free energy landscape for catalysis in mammalian nitric oxide synthases NGH Leferink, S Hay, SEJ Rigby, NS Scrutton The FEBS Journal 282 (16), 3016-3029, 2015	31	2015
Experiment and simulation reveal how mutations in functional plasticity regions guide plant monoterpene synthase product outcome NGH Leferink, KE Ranaghan, V Karuppiah, A Currin, MW Van Der Kamp, ... ACS catalysis 8 (5), 3780-3791, 2018	29	2018
Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers ST Ahmed, NGH Leferink, NS Scrutton Molecular Catalysis 467, 95-110, 2019	26	2019
Communication between L–galactono–1,4–lactone dehydrogenase and cytochrome c M Hervás, Q Bashir, NGH Leferink, P Ferreira, B Moreno‐Beltrán, ... The FEBS journal 280 (8), 1830-1840, 2013	24	2013
Laser‐flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper‐dependent nitrite reductase NGH Leferink, RR Eady, SS Hasnain, NS Scrutton The FEBS Journal 279 (12), 2174-2181, 2012	24	2012

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