| Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase K Gotthardt, M Weyand, A Kortholt, PJM Van Haastert, A Wittinghofer The EMBO journal 27 (16), 2239-2249, 2008 | 186 | 2008 |
| Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts G Guaitoli, F Raimondi, BK Gilsbach, Y Gómez-Llorente, E Deyaert, ... Proceedings of the National Academy of Sciences 113 (30), E4357-E4366, 2016 | 157 | 2016 |
| Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis PJM van Haastert, I Keizer-Gunnink, A Kortholt The Journal of cell biology 177 (5), 809-816, 2007 | 150 | 2007 |
| Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations BK Gilsbach, FY Ho, IR Vetter, PJM Van Haastert, A Wittinghofer, ... Proceedings of the National Academy of Sciences 109 (26), 10322-10327, 2012 | 114 | 2012 |
| Highlighting the role of Ras and Rap during Dictyostelium chemotaxis A Kortholt, PJM van Haastert Cellular signalling 20 (8), 1415-1422, 2008 | 110 | 2008 |
| Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity AM Sabogal-Guáqueta, F Hobbie, A Keerthi, A Oun, A Kortholt, ... Biomedicine & Pharmacotherapy 118, 109295, 2019 | 109 | 2019 |
| Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation BK Gilsbach, A Kortholt Frontiers in molecular neuroscience 7, 32, 2014 | 108 | 2014 |
| Simple system–substantial share: the use of Dictyostelium in cell biology and molecular medicine A Müller-Taubenberger, A Kortholt, L Eichinger European journal of cell biology 92 (2), 45-53, 2013 | 106 | 2013 |
| Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification A Kortholt, R Kataria, I Keizer‐Gunnink, WN Van Egmond, A Khanna, ... EMBO reports 12 (12), 1273-1279, 2011 | 81 | 2011 |
| Regulation of Phagocytosis in Dictyostelium by the Inositol 5‐Phosphatase OCRL Homolog Dd5P4 HM Loovers, A Kortholt, H de Groote, L Whitty, RL Nussbaum, ... Traffic 8 (5), 618-628, 2007 | 81 | 2007 |
| Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins M Blaauw, JC Knol, A Kortholt, J Roelofs, M Postma, AJWG Visser, ... The EMBO journal 22 (19), 5047-5057, 2003 | 79 | 2003 |
| Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement PJM van Haastert, I Keizer-Gunnink, A Kortholt Molecular biology of the cell 28 (7), 922-934, 2017 | 74 | 2017 |
| Phospholipase C regulation of phosphatidylinositol 3, 4, 5-trisphosphate-mediated chemotaxis A Kortholt, JS King, I Keizer-Gunnink, AJ Harwood, PJM Van Haastert Molecular biology of the cell 18 (12), 4772-4779, 2007 | 74 | 2007 |
| Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP S Bader, A Kortholt, PJM Van Haastert Biochemical Journal 402 (1), 153-161, 2007 | 73 | 2007 |
| Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum A Kortholt, H Rehmann, H Kae, L Bosgraaf, I Keizer-Gunnink, G Weeks, ... Journal of biological chemistry 281 (33), 23367-23376, 2006 | 71 | 2006 |
| Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling I Keizer-Gunnink, A Kortholt, PJM Van Haastert The Journal of cell biology 177 (4), 579-585, 2007 | 70 | 2007 |
| A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation A Kortholt, P Bolourani, H Rehmann, I Keizer-Gunnink, G Weeks, ... Molecular biology of the cell 21 (6), 936-945, 2010 | 66 | 2010 |
| A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover E Deyaert, L Wauters, G Guaitoli, A Konijnenberg, M Leemans, ... Nature communications 8 (1), 1008, 2017 | 64 | 2017 |
| Ras activation and symmetry breaking during Dictyostelium chemotaxis A Kortholt, I Keizer-Gunnink, R Kataria, PJM Van Haastert Journal of cell science 126 (19), 4502-4513, 2013 | 64 | 2013 |
| The small GTPases Ras and Rap1 bind to and control TORC2 activity A Khanna, P Lotfi, AJ Chavan, NM Montaño, P Bolourani, G Weeks, ... Scientific reports 6 (1), 25823, 2016 | 56 | 2016 |
