| Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation DP Staus, RT Strachan, A Manglik, B Pani, AW Kahsai, TH Kim, ... Nature 535 (7612), 448-452, 2016 | 322 | 2016 |
| Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc DP Staus, H Hu, MJ Robertson, ALW Kleinhenz, LM Wingler, WD Capel, ... Nature 579 (7798), 297-302, 2020 | 269 | 2020 |
| Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc DP Staus, H Hu, MJ Robertson, ALW Kleinhenz, LM Wingler, WD Capel, ... Nature 579 (7798), 297-302, 2020 | 269 | 2020 |
| Multidimensional tracking of GPCR signaling via peroxidase-catalyzed proximity labeling J Paek, M Kalocsay, DP Staus, L Wingler, R Pascolutti, JA Paulo, SP Gygi, ... Cell 169 (2), 338-349. e11, 2017 | 246 | 2017 |
| Angiotensin analogs with divergent bias stabilize distinct receptor conformations LM Wingler, M Elgeti, D Hilger, NR Latorraca, MT Lerch, DP Staus, ... Cell 176 (3), 468-478. e11, 2019 | 226 | 2019 |
| Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor CM Suomivuori, NR Latorraca, LM Wingler, S Eismann, MC King, ... Science 367 (6480), 881-887, 2020 | 183 | 2020 |
| Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody LM Wingler, C McMahon, DP Staus, RJ Lefkowitz, AC Kruse Cell 176 (3), 479-490. e12, 2019 | 168 | 2019 |
| Conformational basis of G protein-coupled receptor signaling versatility LM Wingler, RJ Lefkowitz Trends in cell biology 30 (9), 736-747, 2020 | 166 | 2020 |
| Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR LM Wingler, MA Skiba, C McMahon, DP Staus, ALW Kleinhenz, ... Science 367 (6480), 888-892, 2020 | 163 | 2020 |
| Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies DP Staus, LM Wingler, RT Strachan, SGF Rasmussen, E Pardon, S Ahn, ... Molecular pharmacology 85 (3), 472-481, 2014 | 147 | 2014 |
| Reiterative Recombination for the in vivo assembly of libraries of multigene pathways LM Wingler, VW Cornish Proceedings of the National Academy of Sciences 108 (37), 15135-15140, 2011 | 134 | 2011 |
| Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library S Ahn, AW Kahsai, B Pani, QT Wang, S Zhao, AL Wall, RT Strachan, ... Proceedings of the National Academy of Sciences 114 (7), 1708-1713, 2017 | 133 | 2017 |
| Rapid generation of potent antibodies by autonomous hypermutation in yeast A Wellner, C McMahon, MSA Gilman, JR Clements, S Clark, KM Nguyen, ... Nature chemical biology 17 (10), 1057-1064, 2021 | 81 | 2021 |
| Discovery of β2 adrenergic receptor ligands using biosensor fragment screening of tagged wild-type receptor T Aristotelous, S Ahn, AK Shukla, S Gawron, MF Sassano, AW Kahsai, ... ACS medicinal chemistry letters 4 (10), 1005-1010, 2013 | 78 | 2013 |
| Conformationally selective RNA aptamers allosterically modulate the β 2-Adrenoceptor AW Kahsai, JW Wisler, J Lee, S Ahn, TJ Cahill III, SM Dennison, DP Staus, ... Nature chemical biology 12 (9), 709-716, 2016 | 77 | 2016 |
| Small-molecule positive allosteric modulators of the β2-adrenoceptor isolated from DNA-encoded libraries S Ahn, B Pani, AW Kahsai, EK Olsen, G Husemoen, M Vestergaard, L Jin, ... Molecular pharmacology 94 (2), 850-861, 2018 | 72 | 2018 |
| Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling DP Staus, LM Wingler, M Choi, B Pani, A Manglik, AC Kruse, RJ Lefkowitz Proceedings of the National Academy of Sciences 115 (15), 3834-3839, 2018 | 64 | 2018 |
| G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor M Choi, DP Staus, LM Wingler, S Ahn, B Pani, WD Capel, RJ Lefkowitz Science signaling 11 (544), eaar7084, 2018 | 59 | 2018 |
| Detergent-and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein–coupled receptors DP Staus, LM Wingler, D Pichugin, RS Prosser, RJ Lefkowitz Journal of Biological Chemistry 294 (36), 13218-13223, 2019 | 42 | 2019 |
| Synthetic nanobodies as angiotensin receptor blockers C McMahon, DP Staus, LM Wingler, J Wang, MA Skiba, M Elgeti, ... Proceedings of the National Academy of Sciences 117 (33), 20284-20291, 2020 | 40 | 2020 |
Robert J. LefkowitzJames B. Duke Professor of Medicine, Biochemistry, Chemistry; HHMI, Duke UniversityVerified email at receptor-biol.duke.edu
