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Diego Varela
Diego Varela
Verified email at uchile.cl
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Year
Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants
SE Heron, H Khosravani, D Varela, C Bladen, TC Williams, MR Newman, ...
Annals of Neurology: Official Journal of the American Neurological …, 2007
2442007
NAD (P) H oxidase-derived H2O2 signals chloride channel activation in cell volume regulation and cell proliferation
D Varela, F Simon, A Riveros, F Jørgensen, A Stutzin
Journal of Biological Chemistry 279 (14), 13301-13304, 2004
1662004
D1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entry
AE Kisilevsky, SJ Mulligan, C Altier, MC Iftinca, D Varela, C Tai, L Chen, ...
Neuron 58 (4), 557-570, 2008
1522008
Sarcopenia and androgens: a link between pathology and treatment
C Basualto-Alarcón, D Varela, J Duran, R Maass, M Estrada
Frontiers in endocrinology 5, 116787, 2014
1122014
Regulation of T-type calcium channels by Rho-associated kinase
M Iftinca, J Hamid, L Chen, D Varela, R Tadayonnejad, C Altier, ...
Nature neuroscience 10 (7), 854-860, 2007
1032007
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death
A Becerra, C Echeverría, D Varela, D Sarmiento, R Armisen, ...
Cardiovascular research 91 (4), 677-684, 2011
942011
The voltage‐dependent ClC‐2 chloride channel has a dual gating mechanism
L Zúñiga, MI Niemeyer, D Varela, M Catalán, LP Cid, FV Sepúlveda
The Journal of physiology 555 (3), 671-682, 2004
932004
Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans
F Simon, D Varela, C Cabello-Verrugio
Cellular signalling 25 (7), 1614-1624, 2013
902013
Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death
F Simon, E Leiva-Salcedo, R Armisén, A Riveros, O Cerda, D Varela, ...
Journal of biological chemistry 285 (48), 37150-37158, 2010
772010
TRPM4 is a novel component of the adhesome required for focal adhesion disassembly, migration and contractility
M Cáceres, L Ortiz, T Recabarren, A Romero, A Colombo, ...
PLoS One 10 (6), e0130540, 2015
642015
Effect of an N‐terminus deletion on voltage‐dependent gating of the ClC‐2 chloride channel
D Varela, MI Niemeyer, LP Cid, FV Sepúlveda
The Journal of physiology 544 (2), 363-372, 2002
542002
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway
FA Urra, F Muñoz, M Córdova-Delgado, MP Ramírez, B Peña-Ahumada, ...
Scientific reports 8 (1), 13190, 2018
502018
Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death
F Nunez-Villena, A Becerra, C Echeverría, N Briceno, O Porras, ...
Antioxidants & Redox Signaling 15 (9), 2425-2438, 2011
502011
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel
D Sarmiento, I Montorfano, O Cerda, M Cáceres, A Becerra, ...
Microvascular research 98, 187-196, 2015
462015
Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity
C Echeverría, I Montorfano, T Hermosilla, R Armisén, LA Velásquez, ...
PLoS One 9 (4), e94146, 2014
422014
Hydroxyl radical activation of a Ca2+-sensitive nonselective cation channel involved in epithelial cell necrosis
F Simon, D Varela, AL Eguiguren, LF Díaz, F Sala, A Stutzin
American Journal of Physiology-Cell Physiology 287 (4), C963-C970, 2004
412004
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
C Arredondo, C Cefaliello, A Dyrda, N Jury, P Martinez, I Díaz, A Amaro, ...
Neuron 110 (10), 1656-1670. e12, 2022
402022
OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells
L Pérez, A Vallejos, C Echeverria, D Varela, C Cabello-Verrugio, F Simon
Laboratory Investigation 99 (3), 421-437, 2019
392019
Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity
R Flynn, K Chapman, M Iftinca, R Aboushousha, D Varela, C Altier
Journal of Biological Chemistry 289 (24), 16675-16687, 2014
392014
Activation of H2O2-Induced VSOR Cl- Currents in HTC Cells Require Phospholipase Cγ1 Phosphorylation and Ca2+ Mobilisation
D Varela, F Simon, P Olivero, R Armisén, E Leiva-Salcedo, F Jørgensen, ...
Cellular Physiology and Biochemistry 20 (6), 773-780, 2007
392007
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